Lloyd's open form 1980 and 1990: born of necessity, has it succeeded?

In earlier shipping days, salvage services were often provided to vessels and maritime properties in danger at sea by individual acts. This was done without salvage contract between the parties. The recent availability of instantaneous means of communication and especially motor driven vessels has resulted in services in the nature of salvage having come to be governed frequently by an agreement in which both the provider and the recipient have been held to owe duties to each other. A factor contributing to this development was the introduction of· Standard Forms of Salvage Agreements. These provided for quantification of the salvor's remuneration by arbitration if it could not be agreed upon by the parties

A text message intervention for quitting cigarette smoking among young adults experiencing homelessness: study protocol for a pilot randomized controlled trial.

BackgroundCigarette smoking is much more prevalent among young people experiencing homelessness than in the general population of adolescents and young adults. Although many young homeless smokers are motivated to quit, there are no empirically-evaluated smoking cessation programs for this population. It is important that any such program address the factors known to be associated with quitting-related outcomes among homeless young people, to provide ongoing support in a way that accommodates the mobility of this population, and does not rely on scarce service provider resources for its delivery. The objective of this project is to develop and pilot test a text messaging-based intervention (TMI), as an adjunct to brief cessation counseling and provision of nicotine patches, to help homeless young people who want to quit smoking.Methods/designThis pilot study will utilize a cluster cross-over randomized controlled design with up to 80 current smokers who desire to quit and are recruited from three drop-in centers serving young people experiencing homelessness in the Los Angeles area. All participants will be provided with a minimum standard of care: a 30-min group-based smoking cessation counseling session and free nicotine replacement. Half of these smokers will then also receive the TMI, as an adjunct to this standard care, which will provide 6 weeks of ongoing support for quitting. This support includes continued and more intensive education regarding nicotine dependence, quitting smoking, and relapse; does not require additional agency resources; can be available "on demand" to users; and includes features to personalize the quitting experience. This study will investigate whether receiving the TMI adjunct to standard smoking cessation care results in greater reductions in cigarette smoking compared to standard care alone over a 3-month period.DiscussionThis study has the potential to address an important gap in the clinical research literature on cigarette smoking cessation and provide empirical support for using a TMI to provide ongoing assistance and support for quitting among young smokers experiencing homelessness. Trial registration ClinicalTrials.gov Identifier NCT03874585. Registered March 14, 2019, https://clinicaltrials.gov/ct2/show/record/NCT03874585

Mitochondrial ROS Signaling in Organismal Homeostasis

Generation, transformation, and utilization of organic molecules in support of cellular differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes, mitochondrial oxygen consumption plays a central role in these processes. During the process of oxidative phosphorylation, mitochondria utilize oxygen to generate ATP from organic fuel molecules but in the process also produce reactive oxygen species (ROS). While ROS have long been appreciated for their damage-promoting, detrimental effects, there is now a greater understanding of their roles as signaling molecules. Here, we review mitochondrial ROS-mediated signaling pathways with an emphasis on how they are involved in various basal and adaptive physiological responses that control organismal homeostasis

A reflexive analysis of an original composition for Mellotron using transcriptions of the MKII rhythms and fills presets as a compositional tool

My dissertation is an investigation of the rhythm and fills presets on the Mellotron MKII (1964) through a series of compositions. All the sounds used in these compositions are Mellotron sounds from the MKII, which were edited and arranged using a digital audio workstation (DAW). In this study I dissect the instrument, and outline every aspect of the rhythms and fills presets. In the process, I develop an expanded model of performance practice on the instrument, presenting new playing and compositional possibilities. These are made possible through comprehensively documented analysis of the instrument’s sample set and the tempo, key and pitch permutations achievable through its on-board modulation controls. The Mellotron is significant because it was among the first samplers in history, and quickly became an iconic sound, woven into the cultural fabric of 1960s British pop. The Mellotron was used on The Beatles’ ‘Strawberry Fields Forever’, Led Zeppelin’s ‘Kashmir’, David Bowie’s ‘Space Oddity’, and The Rolling Stones’ ‘2000 Light Years From Home’, to name a few. While the Mellotron is featured on these famous songs, it has never been used as a solo instrument for a long form composition, nor have its samples ever been transcribed. The study takes a reflexive approach, using journals compiled through the composition process to support the development of new Mellotron techniques and compositions. The compositions presented in this study establish and demonstrate the Mellotron’s capability for extended solo work. The new techniques presented here make the Mellotron more practical for improvisation, composition and performance in new musical contexts. Additionally, the research expands scholarly/educational literature on electromechanical keyboards, providing in-depth technical, historical and musical data on the Mellotron.Art History, Visual Arts and MusicologyM. Mus. (Music

Stria Vascularis Dysfunction in a Mouse Model of Mitochondrial Hearing Loss

We recently described a transgenic mouse model of hearing loss induced by over-expression of the mitochondrial ribosomal RNA (rRNA) methyltransferase, TFB1M (Tg-TFB1M). These mice recapitulate maternally inherited deafness caused by the human A1555G mtDNA mutation, which results in increased methylation of the 12S rRNA in mitochondrial ribosomes and tissue-specific susceptibility to apoptosis. The present study aims to identify the specific cellular and tissue based pathologies underlying this form of deafness