New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

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Algorithms and analysis of scheduling for loops with minimum switchin

Efficent Algorithm of Energy Minimization for Heterogeneous Wireless Sensor Network

International Conference on Embedded and Ubiquitous Computing (EUC 2006), Seoul, Korea, 1-4 Aug 2006Energy and delay are critical issues for wireless sensor networks since most sensors are equipped with non-rechargeable batteries that have limited lifetime. Due to the uncertainties in execution time of some tasks, this paper models each varied execution time as a probabilistic random variable and incorporating applications’ performance requirements to solve the MAP (Mode Assignment with Probability) problem. Using probabilistic design, we propose an optimal algorithm to minimize the total energy consumption while satisfying the timing constraint with a guaranteed confidence probability. The experimental results show that our approach achieves significant energy saving than previous work. For example, our algorithm achieves an average improvement of 32.6% on total energy consumption.Department of Computin

Scheduling Temporal Data with Dynamic Snapshot Consistency Requirement in Vehicular Cyber-Physical Systems

Timely and efficient data dissemination is one of the fundamental requirements to enable innovative applications in vehicular cyber-physical systems (VCPS). In this work, we intensively analyze the characteristics of temporal data dissemination in VCPS. On this basis, we formulate the static and dynamic snapshot consistency requirements on serving real-time requests for temporal data items. Two online algorithms are proposed to enhance the system performance with different requirements. In particular, a reschedule mechanism is developed to make the scheduling adaptable to the dynamic snapshot consistency requirement. A comprehensive performance evaluation demonstrates the superiority of the proposed algorithms. © 2014 Copyright held by the Owner/Author. Publication rights licensed to ACM.

Quality-of-Experience-Oriented Autonomous Intersection Control in Vehicular Networks

Recent advances in autonomous vehicles and vehicular communications are envisioned to enable novel approaches to managing and controlling traffic intersections. In particular, with intersection controller units (ICUs), passing vehicles can be instructed to cross the intersection safely without traffic signals. Previous efforts on autonomous intersection control mainly focused on guaranteeing the safe passage of vehicles and improving intersection throughput, without considering the quality of the travel experience from the passengers' perspective. In this paper, we aim to design an enhanced autonomous intersection control mechanism, which not only ensures vehicle safety and enhances traffic efficiency but also cares about the travel experience of passengers. In particular, we design the metric of smoothness to quantitatively capture the quality of experience. In addition, we consider the travel time of individual vehicles when passing the intersection in scheduling to avoid a long delay of some vehicles, which not only helps with improving intersection throughput but also enhances the system's fairness. With the above considerations, we formulate the intersection control model and transform it into a convex optimization problem. On this basis, we propose a new algorithm to achieve an optimal solution with low overhead. Finally, we build the simulation model and implement the algorithm for performance evaluation. Comprehensive simulation results demonstrate the superiority of the proposed algorithm. © 2015 IEEE.

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele