13 research outputs found
Genital chlamydia prevalence in Europe and in non-European high income countries: systematic review and meta-analysis
Background: Accurate information about the prevalence of Chlamydia trachomatis is
needed to assess national prevention and control measures.
Methods: We systematically reviewed population-based cross-sectional studies that
estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I2 statistic, and conducted random effects meta-analysis if appropriate. Metaregression was used to examine the relationship between study characteristics and chlamydia prevalence estimates.
Results: We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/EEA Member States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6% (95% CI 2.4, 4.8, I2 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I2 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I2 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p=0.003 in women, 0.018 in men).
Conclusions: Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countries
Genital Chlamydia Prevalence in Europe and Non-European High Income Countries: Systematic Review and Meta-Analysis
Background Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures. Methods We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I-2 statistic, and conducted random effects meta-analysis if appropriate. Meta-regression was used to examine the relationship between study characteristics and chlamydia prevalence estimates. Results We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/ EEAMember States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6%(95% CI 2.4, 4.8, I-2 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I-2 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I-2 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p = 0.003 in women, 0.018 in men). Conclusions Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countrie
Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis: DATASET
Changes in chlamydia control activities in Europe between 2007 and 2012 : a cross-national survey
Background: In 2012, the levels of chlamydia control activities including primary prevention, effective case management with partner management and surveillance were assessed in 2012 across countries in the European Union and European Economic Area (EU/EEA), on initiative of the European Centre for Disease Control (ECDC) survey, and the findings were compared with those from a similar survey in 2007. Methods: Experts in the 30 EU/EEA countries were invited to respond to an online questionnaire; 28 countries responded, of which 25 participated in both the 2007 and 2012 surveys. Analyses focused on 13 indicators of chlamydia prevention and control activities; countries were assigned to one of five categories of chlamydia control. Results: In 2012, more countries than in 2007 reported availability of national chlamydia case management guidelines (80% vs. 68%), opportunistic chlamydia testing (68% vs. 44%) and consistent use of nucleic acid amplification tests (64% vs. 36%). The number of countries reporting having a national sexually transmitted infection control strategy or a surveillance system for chlamydia did not change notably. In 2012, most countries (18/25, 72%) had implemented primary prevention activities and case management guidelines addressing partner management, compared with 44% (11/25) of countries in 2007. Conclusion: Overall, chlamydia control activities in EU/EEA countries strengthened between 2007 and 2012. Several countries still need to develop essential chlamydia control activities, whereas others may strengthen implementation and monitoring of existing activities
Changes in chlamydia control activities in Europe between 2007 and 2012: a cross-national survey
Summary of characteristics of included studies.
<p>Abbreviations: EIA, enzyme immunoassay test; EU/EEA, European Union or European Economic Area Member States; IF, immunofluorescence test; M, men; NAAT, nucleic acid amplification test; OECD, Organization for Economic Cooperation and Development; STI, sexually transmitted infections; W: women.</p><p><sup>a</sup> Numbers from technical report Erens et al. 2001 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115753#pone.0115753.ref024" target="_blank">24</a>].</p><p><sup>b</sup> Response rates from online results for 2007–2008 <a href="http://www.cdc.gov/nchs/nhanes/response_rates_CPS.htm" target="_blank">http://www.cdc.gov/nchs/nhanes/response_rates_CPS.htm</a>.</p><p>Summary of characteristics of included studies.</p
Forest plot, overall estimate of chlamydia prevalence in women and men of all ages in EU/EEA and other high-income OECD countries in all included studies. CI, confidence interval.
<p>The small filled diamond shows the point estimate, the lines either side are the 95% CI. Each row is a study or group within a study, with separate estimates from women and men, where available. In Denmark 2002, Group 1 received home sampling kits, Group 2 had to request a sampling kit by post. In USA 2012, separate estimates are reported for five survey cycles of the National Health and Nutrition Surveys. In Netherlands 2010, separate estimates were reported separately for Amsterdam and Rotterdam.</p
Flow diagram of study identification, inclusion and exclusion.
<p>Flow diagram of study identification, inclusion and exclusion.</p
Meta-regression analysis of chlamydia prevalence estimates in women and men aged ≤25 years against calculated sex-specific response rate for all women and men in the study, in EU/EEA and other high-income OECD countries.
<p>The size of the open circle corresponds to the precision of the prevalence estimate. n = number of studies. For women, n = 27, P = 0.003, I<sup>2</sup> 82.4%; men, n = 18, P = 0.018, I<sup>2</sup> 87.6%.</p
Forest plot, estimates of chlamydia prevalence in men ≤ 26 years in EU/EEA and other high-income OECD countries. CI, confidence interval.
<p>The small filled diamond shows the point estimate, the lines either side are the 95% CI. Each row is a study or group within a study. In Denmark 2002, Group 1 received home sampling kits, Group 2 had to request a sampling kit by post. Estimates are shown separately for sexually experienced participants only or for the overall sample, in either national or sub-national populations.</p