Food Insecurity and Cardiovascular Risk Factors in U.S. Adolescents

Introduction: Disparities in cardiovascular diseases are one of today’s most important public health challenges. Pathological processes related to modifiable cardiovascular risk factors have shown to begin in childhood and disparities in these risk factors have been reported in adolescence. Food insecurity is significantly associated with cardiovascular risk factors in adults; however, little is known about cardiovascular risk in food insecure adolescents. Objective: The objective of this study was to examine the relationship between food insecurity and cardiovascular risk factors in U.S. adolescents aged 12-17 years. Methods: Using cross-sectional data on 1,853 adolescents aged 12-17 years from the National Health and Nutrition Examination Survey 2007-2012, we examined the association between food insecurity and cardiovascular risk factors. Food security status was measured using the validated 18-item Household Food Security Survey Module. Cardiovascular risk was measured based on American Heart Association’s Life’s Simple 7 factors (LS7; tobacco smoke exposure, diet quality, physical activity, body mass index, blood pressure, total cholesterol, blood glucose levels). Results: Nearly 10.0% of U.S. adolescents were food insecure. A total of 26.1% of adolescents failed to attain ideal scores on more than 5 LS7 components. In bivariate analyses, food secure, in comparison to food insecure adolescents, were more likely to have ideal scores on 5-7 LS7 components (75.1% vs. 63.0%, p = 0.0089). In multivariate models adjusted for demographic, socioeconomic, health, and health care access factors, food insecurity was not significantly associated with cardiovascular risk in adolescents. However, food insecure adolescents had significantly lower odds of attaining ideal levels of tobacco smoke exposure ([OR] = 0.54 [95% CI 0.31, 0. 94]) than food secure adolescents. Adolescents living in families with incomes below the Federal Poverty Level (Odds Ratio [OR] = 0.59 [95% CI 0.40,0.86]) had significantly lower odds of having ideal LS7 scores and lower odds of attaining ideal scores on tobacco smoke exposure ([OR] = 0.25 [95% CI 0.13, 0.49]) and physical activity ([OR] = 0.60 [95% CI 0.38, 0.95]). Conclusion: Although cardiovascular risk is not more pronounced in food insecure adolescents than their counterparts, adolescents from low SES households may be at particular risk of developing cardiovascular diseases. Multifaceted and tailored strategies inclusive of nutrition assistance are needed to facilitate effective cardiovascular risk prevention as these vulnerable populations transition into early adulthood

Hartmut von Hentig: Bewährung. Von der nützlichen Erfahrung, nützlich zu sein. Wien: Hanser 2006 (106 S.) [Rezension]

Rezension von: Hartmut von Hentig: Bewährung. Von der nützlichen Erfahrung, nützlich zu sein. Wien: Hanser 2006 (106 S.; ISBN 3-446-20776-7; 12,50 EUR)

Jörg Zirfas / Benjamin Jörissen: Phänomenologien der Identität. Human-, sozial- und kulturwissenschaftliche Analysen. Wiesbaden: VS Verlag für Erziehungswissenschaften 2007 (272 S.) [Rezension]

Rezension von: Jörg Zirfas / Benjamin Jörissen: Phänomenologien der Identität. Human-, sozial- und kulturwissenschaftliche Analysen. Wiesbaden: VS Verlag für Erziehungswissenschaften 2007 (272 S.; ISBN 978-3-8100-4018-5; 29,90 EUR)

Michael Wimmer: Dekonstruktion und Erziehung. Studien zum Paradoxieproblem in der Pädagogik. Bielefeld: transcript 2006 (421 S.) [Rezension]

Rezension von: Michael Wimmer: Dekonstruktion und Erziehung. Studien zum Paradoxieproblem in der Pädagogik. Bielefeld: transcript 2006 (421 S.; ISBN 3-89942-469-7; 33,80 EUR)

Birgitta Fuchs / Christian Schönherr (Hrsg.): Urteilskraft und Pädagogik. Beiträge zu einer pädagogischen Handlungstheorie. Würzburg: Königshausen & Neumann 2007 (273 S.) [Rezension]

Rezension von: Birgitta Fuchs / Christian Schönherr (Hrsg.): Urteilskraft und Pädagogik. Beiträge zu einer pädagogischen Handlungstheorie. Würzburg: Königshausen & Neumann 2007 (273 S.; ISBN 978-3-8260-3597-5; 38,00 EUR)

Mehr Praxis im künstlerischen Lehramtsstudium! Welche Praxis? Bildungswissenschaftliche Beiträge zur Schulpraxis

Im Beitrag gehen die Autorinnen auf Besonderheiten des künstlerischen Lehramtsstudiums ein und betonen vor dem Hintergrund der fachlichen und institutionellen Spezifika die curriculare Verankerung von praxisbezogenen Lehrveranstaltungen sowie Formen der Begleitung und Kooperation. Im Fokus steht die Frage, welchen Beitrag der Anteil der allgemeinen bildungswissenschaftlichen Grundlagen zur Schulpraxis leistet. (DIPF/Orig.

Nutrition and Well-Being

The relationship of nutrition-related factors with well-being in people 80 and older has received little attention. Therefore, this chapter explores the relationships of depression and depressive symptoms, as a measure of well-being, with appetite, body weight changes, underweight, and obesity as measures of nutritional status. The sample is from the Georgia Centenarian Study (aged 80 to 89 and 98+ years, see Chapter 9). In bivariate analyses, centenarians with depression consistently had the highest prevalence of underweight when compared to centenarians without depression and all octogenarians (23% to 33% vs. 0% to 16%). When controlled for other demographic factors, clinically relevant depressive symptomatology was associated with appetite loss, while a current diagnosis of depression was associated with recent changes in body weight. However, taking antidepressant medications was not associated with any of the nutrition-related measures. Demographic factors emerged as important predictors of nutritional status. Living in a skilled nursing facility compared to living in the community was associated with a lower risk of appetite loss and higher risk of weight gain; being a centenarian or being female was associated with underweight; and being Black (vs. White) was associated with obesity. Thus, risk factors for poor nutritional status in the oldest may be related to depression as well as to specific demographic factors including age, gender, race, and residence in a skilled nursing facility

Line-field confocal optical coherence tomography: a new tool for the differentiation between nevi and melanomas?

SIMPLE SUMMARY: Typical benign nevi and advanced melanomas can be easily discriminated, but there are still some melanocytic lesions where even experts are not sure about the correct diagnosis and degree of malignity. The high penetration depth of optical coherence tomography (OCT) allows an assessment of tumor thickness of the lesion precisely, but without cellular resolution the differentiation of melanocytic lesions remains difficult. On the other hand, reflectance confocal microscopy (RCM) allows for very good morphological identification of either a nevus or a melanoma, but cannot show the infiltration depth of the lesion because of its low penetration depth. Since the new device of line-field confocal optical coherence tomography (LC-OCT) technically closes the gap between these other two devices, in this study, we wanted to examine if it is possible to differentiate between nevi and melanomas with LC-OCT, and which criteria are the most important for it. ABSTRACT: Until now, the clinical differentiation between a nevus and a melanoma is still challenging in some cases. Line-field confocal optical coherence tomography (LC-OCT) is a new tool with the aim to change that. The aim of the study was to evaluate LC-OCT for the discrimination between nevi and melanomas. A total of 84 melanocytic lesions were examined with LC-OCT and 36 were also imaged with RCM. The observers recorded the diagnoses, and the presence or absence of the 18 most common imaging parameters for melanocytic lesions, nevi, and melanomas in the LC-OCT images. Their confidence in diagnosis and the image quality of LC-OCT and RCM were evaluated. The most useful criteria, the sensitivity and specificity of LC-OCT vs. RCM vs. histology, to differentiate a (dysplastic) nevus from a melanoma were analyzed. Good image quality correlated with better diagnostic performance (Spearman correlation: 0.4). LC-OCT had a 93% sensitivity and 100% specificity compared to RCM (93% sensitivity, 95% specificity) for diagnosing a melanoma (vs. all types of nevi). No difference in performance between RCM and LC-OCT was observed (McNemar’s p value = 1). Both devices falsely diagnosed dysplastic nevi as non-dysplastic (43% sensitivity for dysplastic nevus diagnosis). The most significant criteria for diagnosing a melanoma with LC-OCT were irregular honeycombed patterns (92% occurrence rate; 31.7 odds ratio (OR)), the presence of pagetoid spread (89% occurrence rate; 23.6 OR) and the absence of dermal nests (23% occurrence rate, 0.02 OR). In conclusion LC-OCT is useful for the discrimination between melanomas and nevi

Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress

When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of atherosclerosis, tumors or pulmonary hypertension; diseases that are decisively furthered by the presence of oxidizing agents. Redox sensitive genes, like the zinc finger transcription factor early growth response 1 (Egr-1), play a pivotal role in the pathophysiology of these diseases. Apart from inducing apoptosis, signaling partners like the MEK/ERK pathway or the protein kinase C (PKC) can activate salvage programs such as cell proliferation that do not ameliorate, but rather worsen their outcome. Here, we review the currently available data on Egr-1 related signal transduction cascades in response to oxidative stress in the progression of epidemiologically significant diseases. Knowing the molecular pathways behind the pathology will greatly enhance our ability to identify possible targets for the development of new therapeutic strategies

Human serum metabolic profiles are age dependent

Understanding the complexity of aging is of utmost importance. This can now be addressed by the novel and powerful approach of metabolomics. However, to date, only a few metabolic studies based on large samples are available. Here, we provide novel and specific information on age-related metabolite concentration changes in human homeostasis. We report results from two population-based studies: the KORA F4 study from Germany as a discovery cohort, with 1038 female and 1124 male participants (32–81 years), and the TwinsUK study as replication, with 724 female participants. Targeted metabolomics of fasting serum samples quantified 131 metabolites by FIA-MS/MS. Among these, 71/34 metabolites were significantly associated with age in women/men (BMI adjusted). We further identified a set of 13 independent metabolites in women (with P values ranging from 4.6 × 10−04 to 7.8 × 10−42, αcorr = 0.004). Eleven of these 13 metabolites were replicated in the TwinsUK study, including seven metabolite concentrations that increased with age (C0, C10:1, C12:1, C18:1, SM C16:1, SM C18:1, and PC aa C28:1), while histidine decreased. These results indicate that metabolic profiles are age dependent and might reflect different aging processes, such as incomplete mitochondrial fatty acid oxidation. The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging