29 research outputs found

    CONHECIMENTO, PRÁTICAS E ATITUDES EM RELAÇÃO AO DIAGNÓSTICO DO CÂNCER DE BOCA NA VISÃO DA POPULAÇÃO

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    Este estudo objetivou identificar o grau de conhecimento sobre o câncer bucal em uma amostra populacional da cidade de Curitiba-PR. Um questionário desenvolvido para este projeto foi aplicado a 1000 indivíduos por 3 examinadores. A amostra foi estratificada pelos bairros do município, com abordagem aleatória, dentre os transeuntes, em regiões de maior aglomeração urbana. Os resultados foram tabulados de maneira descritiva e os percentuais calculados para cada questão proposta no questionário, incluindo dados demográficos tais como idade, nível de escolaridade e renda. Aproximadamente 97% dos entrevistados responderam acreditar que o câncer pode ocorrer na boca. Por outro lado, 27% não sabiam identificar quaisquer sinais ou sintomas desta doença. Dentre os fatores de risco 34%, 8% e 1% apontaram tabagismo, etilismo e exposição solar, respectivamente, como os principais causadores do câncer de boca. Os resultados sugerem que a população estudada apresenta um nível maior de conhecimento sobre a possibilidade de malignização da mucosa bucal do que o verificado em outros estudos. Os sinais e sintomas mais comuns do câncer da boca assim como os principais fatores de risco conhecidos não foram, entretanto, respostas freqüentes quantitativamente, sugerindo que maiores esforços são necessários para conscientização da população sobre a doença e principais características

    CONHECIMENTOS, PRÁTICAS E ATITUDES FRENTE AO DIAGNÓSTICO DE CÂNCER DE BOCA NA VISÃO DO CIRURGIÃO-DENTISTA

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    Este estudo avaliou o conhecimento, práticas e atitudes de cirurgiões-dentistas (CDs) em Curitiba em relação às doenças bucais a fim de identificar o índice de CDs que exercem a Estomatologia na sua rotina clínica e verificar seu grau de conscientização sobre a importância do diagnóstico precoce de lesões malignas. Questionários foram aplicados por 3 examinadores no ambiente de trabalho de 100 CDs, selecionados através de randomização dos números de registro no Conselho Regional de Odontologia do Paraná. A doença bucal mais freqüentemente diagnosticada foi a afta (85%). Estão preparados para diagnosticar doenças bucais 54% dos entrevistados. Do total, 44% são procurados por pacientes que buscam tratamento para lesões bucais. Tratam doenças da boca 66% dos CDs, 19% os encaminham para serviços especializados e 15% não souberam responder. Os fatores mais importantes para suspeitar de câncer bucal foram: tempo de evolução (40%) e linfonodos palpáveis (38%). O interesse em se atualizar em patologia bucal foi confirmado por 86% dos dentistas, 4% não se atualizariam por falta de interesse, 4% por área de atuação diversa da Estomatologia e 2% por encerramento de carreira. Os resultados refletiram descuido de alguns CDs com a completa avaliação do estado de saúde bucal dos seus pacientes

    Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic : a randomized clinical trial

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    Background: The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the treatment in type 2 diabetic (T2DM) patients, but high intensity exercise can induce a transient inflammatory state and increase oxidative stress. Nutritional strategies that may contribute to the reduction of oxidative stress induced by acute exercise are necessary. The aim of this study was to examine if n-3 PUFA supplementation intervention can attenuate the inflammatory response and oxidative stress associated with high intensity exercise in this population. As a primary outcome, lipoperoxidation measurements (TBARS and F2-isoprostanes) were selected. Methods: Thirty T2DM patients, without chronic complications, were randomly allocated into two groups: placebo (gelatin capsules) or n-3 PUFA (capsules containing 180 mg of eicosapentaenoic acid and 120 mg of docosahexaenoic acid). Blood samples were collected fasting before and after 8 weeks supplementation. In the beginning and at the end of protocol, an acute exercise was performed (treadmill), and new blood samples were collected before and immediately after the exercise for measurements of oxidative stress and high-sensitivity C-reactive protein (hs-CRP). Results: After the supplementation period, a decrease in triglycerides levels was observed only in n-3 PUFA supplementation group (mean difference and 95% CI of 0.002 (0.000–0.004), p = 0.005). Supplementation also significantly reduced TRAP levels after exercise (mean difference and 95% CI to 9641 (− 20,068–39,351) for − 33,884 (− 56,976 - -10,793), p = 0.004, Cohen’s d effect size = 1.12), but no significant difference was observed in n-3 PUFA supplementation group in lipoperoxidation parameters as TBARS (mean difference and 95% CI to − 3.8 (− 10–2.4) for − 2.9 (− 1.6–7.4) or F2-isoprostanes (mean difference and 95% CI -0.05 (− 0.19–0.10) for − 0.02 (− 0.19–0.16), p > 0.05 for both. Conclusion: PUFA n-3 supplementation reduced triglycerides as well as TRAP levels after exercise, without a significant effect on inflammatory and oxidative stress markers. This study is registered at ClinicalTrials.gov with the registration number of NCT03182712

    Assets acquisition planning

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    At the 127th European Study Group with Industry an energy sector com- pany proposed an industrial challenge that consisted on the asset acquisi- tion planning for its liquefied petroleum gas (LPG) cylinder business, one of the most recent business areas in the company. This business area is still in a growing phase and to satisfy the market needs and assure a sustainable growth a very tight control of the main assets, the LPG cylinders, is of paramount importance. Therefore, a detailed planning of all the as- sets acquisition is required, taking into consideration several variables: sales growth rate, seasonality, cylinder rotation and corresponding return rate to the filling plant. The challenge was to develop a model for the assets acquisition planning. In order to tackle this challenge, it was necessary to forecast the demand. For that purpose, time series techniques were used, in particular, moving averages and exponential smoothing. The results show that the seasonality does not explain all the variation of the demand, therefore it is necessary to use a model that would consider other possible explanatory variables. According to several authors, gas consumption may be influenced by several aspects, such as, atmospheric temperatures, heliophany (a measure of the day luminosity), wind, relative humidity, rains, minimum and maximum temperatures, demand in previous periods, and prices. The forecast of bottled propane gas sales and return rate was also addressed through multivariate linear regression. Regression models for the monthly number of bottles of types A and B were obtained, having pre- sented good percentages of explained variability with the variables under study. The main goal of the challenge, the acquisition plan, was addressed u ing inventory models with reverse logistics. Several deterministic approaches have been considered to enable different aspects in the framework. A new inventory model has been developed to contemplate the three possible des- tinations of returned bottles: cleaning, requalification, or disposal. The models were implemented in Excel and can be tested, using PRIO estimates of holding costs and fixed setup costs, and the forecasts of sales and return rate computed previously
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