Arc tracking control in insulation systems for aeronautic applications: challenges, opportunities, and research needs

Next generation aircrafts will use more electrical power to reduce weight, fuel consumption, system complexity and greenhouse gas emissions. However, new failure modes and challenges arise related to the required voltage increase and consequent rise of electrical stress on wiring insulation materials, thus increasing the risk of electrical arc appearance. This work performs a critical and comprehensive review concerning arc tracking effects in wiring insulation systems, underlying mechanisms, role of materials and possible mitigation strategies, with a special focus on aircraft applications. To this end an evaluation of the scientific and technological state of the art is carried out from the analysis of theses, research articles, technical reports, international standards and white papers. This review paper also reports the limitations of existing insulation materials, standard test methods and mitigation approaches, while identifying the research needs to comply with the future demands of the aircraft industryPeer ReviewedPostprint (published version

L’architecture à la formation des enseignants: Du tangram aux carreaux Nazari. Firmitas, utilitas et ‘venustas’

El trabajo se ha realizado para valorar la arquitectura como herramienta pedagógica para la adquisición de conceptos geométricos por parte del profesorado de las primeras etapas de la educación. La investigación ha sido incluida dentro del proyecto I+D de referencia EDU2011-29114 y de título Escuelas para la Justicia Social. MÉTODO. La experiencia se ha servido del trabajo previo que han venido desarrollando los autores de este artículo desde el año 2003. Se han resuelto dos encuestas que se han venido usando como pre y postest, para evaluar el nivel de satisfacción y aprovechamiento de los cursos que se han impartido en los Centros Territoriales de Innovación y Formación del profesorado de la Comunidad de Madrid. Del mismo modo se ha secuenciado una serie de sesiones de trabajo con las que atender esta formación específica. RESULTADOS. El hallazgo principal del estudio es la constatación de las posibilidades de la arquitectura como elemento interdisciplinar válido para la adquisición de conocimientos geométricos. DISCUSIÓN. El trabajo se integra junto con otras propuestas innovadoras de didáctica de las Ciencias Experimentales y las Matemáticas de las que solo se reflejan en este artículo las referidas a la geometría. Los comentarios recibidos por parte de los docentes que han sido formados con las mismas son positivos y han sido trasladado a las aulas satisfactoriamente, pero de momento no tenemos registro nominal cuantitativo de sus resultadosThis paper is intended to value Architecture as a pedagogic tool in the acquisition of geometric concepts by teachers at the early stages in Education. This research study has been included in a research project (ref. EDU2011-29114) entitled “Escuelas para la Justicia Social” (“Schools for Social Justice”). METHOD. This experience has been drawn on previous studies which have been conducted by the authors of the present paper since 2003. The designs of two questionnaires have been later used as pre- and post-tests in order to assess the degree of satisfaction and performance achieved throughout a number of courses given in Local Innovation and Teacher Training Centers in the Autonomous Community of Madrid . Similarly, a series of working sessions have been sequenced in order to address this specific training. RESULTS. The main finding of the present study consists in revealing the possibilities offered by Architecture as an interdisciplinary element valid in the acquisition of geometric knowledge. DISCUSSION. The present paper is integrated into other ground-breaking proposals in the field of didactics of Experimental Sciences and Mathematics of which only those pertaining to geometry are under study here. Although the comments received by teachers have been positive and have been successfully implemented in classrooms, at present the authors of this paper still do not have a quantitative nominal register of the resultsLe travail a été effectué pour valoriser l’architecture comme un outil pédagogique pour l’acquisition de concepts géométriques par des enseignants dans les premières étapes d’enseignement. La recherche est encadrée dans le projet R+D de référence EDU2011-29114 dont le titre est: Ecoles pour la Justice Sociale. MÉTHODE. L’expérience est conséquence des travaux pré- cédents qui ont été développés par les auteurs de cet article après 2003. On a fait deux enquêtes qui ont été utilisées comme pré et post-test, pour évaluer le niveau de satisfaction et de réussite dans les cours qui ont été enseignés dans les Centres Territoriaux d’Innovation et de Formation des enseignants à Madrid (*). De la même façon, on a séquencé une série de séances de travail grâce auxquelles on pourrait donner réponse à cette formation spécifique. RÉSULTATS. La principale conclusion de l’étude est la constatation des possibilités de l’architecture comme un élément interdisciplinaire valable pour l’acquisition de connaissances géométriques. DISCUSSION. Le travail est intégré a vec d’autres nouvelles propositions d’enseignement de la Didactique des Sciences Expérimentales et de Mathématiques desquelles on a seulement montré dans cet article celles qui se réfèrent à la géométrie. Les commentaires reçus par les enseignants qui ont été formés sous le même modèle sont favorables et la méthodologie a été implémentée avec succès. Pour le moment les auteurs de l’article n’ont aucune trace nominale quantitative de leurs résultat

Microangiopatía trombótica en paciente con síndrome antisintetasa : a propósito de un caso

Las microangiopatías trombóticas se caracterizan por presentar anemia hemolítica microangiopática asociada a plaquetopenia, fallo renal y lesión neurológica. El Síndrome anti-sintetasa es una entidad poco frecuente perteneciente al grupo de las miopatías inflamatorias idiopáticas. El objetivo de esta presentación es comunicar una paciente que desarrolló una púrpura trombocitopénica trombótica en el contexto de un Síndrome anti-sintetasa, asociación inusualmente reportada.The thrombotic microangiopathies are characterized by the association of microangiopathic hemolytic anemia, thrombocytopenia, renal failure and neurological injury and the antisynthetase syndrome is a rare condition that has been included in the group of idiopatic inflammatory skeletal muscle disease. We report a patient presenting a thrombotic thrombocytopenic purpura in the context of an anti-synthetase syndrome wich is an innusual reported asociation.Fil: Gómez Centurión, Santiago. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Clínica MédicaFil: Vera, Carolina. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Clínica MédicaFil: Ruiz, Pedro. Hospital Luis Lagomaggiore (Mendoza, Argentina)Fil: Salomón, Susana Elsa. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: Carena, José Alberto. Hospital Luis Lagomaggiore (Mendoza, Argentina). Servicio de Clínica Médic

Bis[1,2-bis­(dimethyl­phosphino)ethane-κ2 P,P′]rhodium(I) dichlorido[(1,2,5,6-η)-1,5-cyclo­octa­diene]rhodium(I)

In the title complex, [Rh(C6H16P2)2][RhCl2(C8H12)], the asymmetric unit contains two [Rh(dmpe)2] [dmpe = 1,2-bis­(dimethyl­phosphino)ethane] half-cations, lying on inversion centers, and an [RhCl2(cod)]− (cod = 1,5-cyclo­octa­diene) anion, wherein Rh is coordinated by two chloride ligands and two olefinic π-bonds of the cyclo­octa­diene ligand. The Rh atoms in the cations and anion exhibit square-planar coordination and are separated without any unusual inter­actions

Creación de una red superpuesta para el despliegue de servicios de colaboración.

Las aplicaciones de trabajo colaborativo hacen uso se múltiples flujos de datos, viéndose dificultado su funcionamiento por la presencia de cortafuegos y equipos que traducen las direcciones de red. En este artículo se describe una solución a estos problemas consistente en la creación de una red superpuesta a través de la cual se encapsula todo el tráfico del servicio de colaboración. Se detallan el funcionamiento multipuerto y otras características de la red superpuesta que la hacen especialmente interesante para cualquier aplicación que tenga problemas con dispositivos de red intermedios. Finalmente, se exponen los resultados de aplicar esta solución a un programa de multiconferencia (Isabel) y se explica cómo extender la solución a otras aplicaciones

Chiral symmetry restoration from the hadronic regime

We discuss recent advances on QCD chiral symmetry restoration at finite temperature, within the theoretical framework of Effective Theories. U(3) Ward Identities are derived between pseudoscalar susceptibilities and quark condensates, allowing to explain the behaviour of lattice meson screening masses. Unitarized interactions and the generated f₀(500) thermal state are showed to play an essential role in the description of the transition through the scalar susceptibility

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

[ Abstract] The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn).This work was supported by Operational Program Research, Development, and Education-Project ‘MSCAfellow4@MUNI’ (No. CZ.02.2.69/0.0/0.0/20_079/0017045) and the Spanish Ministry of Universities for a Maria Zambrano funding (RSU.UDC.MZ09 [RSU.UDC.MZ11]) transferred by the European Union-Next Generation EU. We acknowledge CzechNanoLab Research Infrastructure (LM2018110), supported by the Ministry of Education, Youth and Sports of the Czech Republic (MEYS CR). We are grateful to Prof. Vladimír Šindelář and Prof. Petr Klan for allowing us to use the MW reactor, UV-vis and fluorescence spectrometer, supported by RECETOX research infrastructure (via MEYS CR under LM2018121). M.F. is grateful to Instituto de Salud Carlos III (ISCIII) for project No DTS20/00109 (AES20-ISCIII) and PI22/00789 (AES22-ISCIII). M.F. and K.O.P. acknowledge the support of Microscopy & Dynamic Imaging Unit of CNIC, Madrid, Spain. The Unit is part of the ReDiB-ICTS and has the support of FEDER, “Una manera de hacer Europa.” The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). We would also like to thank funding from the research project PID2022-136417NB-I00 financed by MCIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”, and from the Research Thematic Network RED2022-134091-T financed by MCIN/AEI/10.13039/501100011033.Česká republika. Ministerstvo školství, mládeže a tělovýchovy České republiky; LM2018110Česká republika. RECETOX; LM201812

First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies

We are thankful for the funding from the research project RTI2018-094322-B-I00, financed by MCIN/AEI/10.13039/501100011033/; “ERDF A way of making Europe”; and the Research Thematic Network RED2022-134091-T, financed by MCIN/AEI/10.13039/501100011033. Á.M.-M. is grateful to the European Union and Junta de Andalucía for a post-doc grant (Ayuda a la contratación de personal investigador doctor).Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ph16101380/s1Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack of investment in research, despite the fact that almost one million new cases are reported every year. Four 7-oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine (HftpO) first-row transition complexes (Cu, Co, Ni, Zn) have been studied for the first time in vitro against five different species of Leishmania spp. (L. infantum, L. braziliensis, L. donovani, L. peruviana and L. mexicana) as well as Trypanosoma cruzi, showing higher efficacy than the reference commercial drugs. UV and luminescence properties were also evaluated. As a proof of concept, anchoring of a model high-effective-metal complex as an antiparasitic agent on silica nanoparticles was carried out for the first time, and drug-release behaviour was evaluated, assessing this new approach for drug vehiculation.MCIN/AEI/10.13039/501100011033/ RTI2018-094322-B-I00, RED2022-134091-TERDF A way of making EuropeEuropean UnionJunta de Andalucí

Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity.This research was funded by Ministerio de Ciencia, Innovación y Universidades Spain-FEDER, grants number CTQ2015-66164-R and CTQ2017-90802-REDT and by Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) (PICT 2015 Nº1558)