Educators’ Reflections on Empowerment in a Gender Responsive Program for Women Offenders

We explore women educators’ experiences teaching in a gender-responsive program for women who are incarcerated. Themes including fostering empowerment, motivations for teaching, and tensions teaching emancipatory content in jail

ResolanaPaving Paths Toward Transformation with Incarcerated Women

The purpose of this study was to elicit the experiences of women who participated in a gender-responsive program in jail. Results indicate the holistic programming and learning environment was an emancipatory container where transformation could occur through interpersonal and intrapersonal engagement. Findings have implications for the education of incarcerated women

“Doin’ Whatever I Had to Do to Survive”: A Study of Resistance, Agency, and Transformation in the Lives of Incarcerated Women

The number of women who are incarcerated has increased significantly in the past few decades. Originally designed to manage male offenders, jails and prisons are ill-equipped to address the unique needs of women inmates whose paths to incarceration often include histories of trauma, abuse, and addiction. This qualitative study investigated the lives of 13 women who while incarcerated at Dallas County Jail, participated in an educational program, Resolana. The purpose of this study was to understand the women’s lives prior to incarceration, as well as the impact of the program and changes they experienced, if any, as a result of what they were learning. Data were collected using semi-structured, life history interviews, and by engaging in field observations as a volunteer for each class for a period of one week. An in-depth analysis through a critical lens, using a holistic-content narrative analysis method, was done with one participant’s life history. The findings are presented as an ethnodrama illuminating the cultural, social, personal, and legal systems of oppression that she survived and that contributed to her path to incarceration. Analyzed through a lens of agency and resistance, the findings that emerged from an analysis of all the participant’s life histories reveal that the women’s criminalized actions were often survival responses. The women employed various strategies, both legal and illegal, in response to people or situations involving control, power or domination over their lives. An analysis of the women’s experiences with Resolana through a transformative learning theoretical framework indicates that the women experience transformation in various ways and to varying degrees. The learning environment served as a container in which transformative learning could be cultivated through opportunities for interpersonal and intrapersonal engagement. The results of this study reveal the need for more and targeted advocacy and education for incarcerated and formerly incarcerated women. The results also indicate that the process and content of Resolana’s programming had a transformative impact on participants, and for some, the transformation was enduring. Finally, the results challenge definitions of criminal behavior in the context interlocking systems of oppression, and encourage thinking about alternatives to incarceration

Comparing estimates of influenza-associated hospitalization and death among adults with congestive heart failure based on how influenza season is defined

<p>Abstract</p> <p>Background</p> <p>There is little consensus about how the influenza season should be defined in studies that assess influenza-attributable risk. The objective of this study was to compare estimates of influenza-associated risk in a defined clinical population using four different methods of defining the influenza season.</p> <p>Methods</p> <p>Using the Studies of Left Ventricular Dysfunction (SOLVD) clinical database and national influenza surveillance data from 1986–87 to 1990–91, four definitions were used to assess influenza-associated risk: (a) three-week moving average of positive influenza isolates is at least 5%, (b) three-week moving average of positive influenza isolates is at least 10%, (c) first and last positive influenza isolate are identified, and (d) 5% of total number of positive isolates for the season are obtained. The clinical data were from adults aged 21 to 80 with physician-diagnosed congestive heart failure. All-cause hospitalization and all-cause mortality during the influenza seasons and non-influenza seasons were compared using four definitions of the influenza season. Incidence analyses and Cox regression were used to assess the effect of exposure to influenza season on all-cause hospitalization and death using all four definitions.</p> <p>Results</p> <p>There was a higher risk of hospitalization associated with the influenza season, regardless of how the start and stop of the influenza season was defined. The adjusted risk of hospitalization was 8 to 10 percent higher during the influenza season compared to the non-influenza season when the different definitions were used. However, exposure to influenza was not consistently associated with higher risk of death when all definitions were used. When the 5% moving average and first/last positive isolate definitions were used, exposure to influenza was associated with a higher risk of death compared to non-exposure in this clinical population (adjusted hazard ratios [HR], 1.16; 95% confidence interval [CI], 1.04 to 1.29 and adjusted HR, 1.19; 95% CI, 1.06 to 1.33, respectively).</p> <p>Conclusion</p> <p>Estimates of influenza-attributable risk may vary depending on how influenza season is defined and the outcome being assessed.</p

Repeat controlled human malaria infection of healthy UK adults with blood-stage plasmodium falciparum:Safety and parasite growth dynamics

In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by controlled human malaria infection (CHMI). We report the findings of repeat homologous blood-stage Plasmodium falciparum (3D7 clone) CHMI studies VAC063C (ClinicalTrials.gov NCT03906474) and VAC063 (ClinicalTrials.gov NCT02927145). In total, 24 healthy, unvaccinated, malaria-naïve UK adult participants underwent primary CHMI followed by drug treatment. Ten of these then underwent secondary CHMI in the same manner, and then six of these underwent a final tertiary CHMI. As with primary CHMI, malaria symptoms were common following secondary and tertiary infection, however, most resolved within a few days of treatment and there were no long term sequelae or serious adverse events related to CHMI. Despite detectable induction and boosting of anti-merozoite serum IgG antibody responses following each round of CHMI, there was no clear evidence of anti-parasite immunity (manifest as reduced parasite growth in vivo) conferred by repeated challenge with the homologous parasite in the majority of volunteers. However, three volunteers showed some variation in parasite growth dynamics in vivo following repeat CHMI that were either modest or short-lived. We also observed no major differences in clinical symptoms or laboratory markers of infection across the primary, secondary and tertiary challenges. However, there was a trend to more severe pyrexia after primary CHMI and the absence of a detectable transaminitis post-treatment following secondary and tertiary infection. We hypothesize that this could represent the initial induction of clinical immunity. Repeat homologous blood-stage CHMI is thus safe and provides a model with the potential to further the understanding of naturally acquired immunity to blood-stage infection in a highly controlled setting. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT03906474, NCT02927145

How many human proteoforms are there?

Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype