El síndrome de alienación parental (SAP) y su valor probatorio en el proceso administrativo de guarda y custodia de niños, niñas y adolescentes

Actualmente el poder legislativo de Colombia, se ha encaminado a legislar de manera preferente por la protección de los Niños, Niñas y Adolescentes, estableciendo como Principio Constitucional el Cuidado Personal, la Educación, Recreación, Salud, Alimentación Sana, derecho a recibir amor, el derecho de los niños a tener una Familia y no ser separados ni violentaos dentro de ella. Es ésta la razón que pone importancia para que dentro del presente trabajo de investigación jurídica se escriba sobre el Síndrome de Alienación Parental en adelante SAP en el entendido que este es una disfunción en uno de los padres denominado progenitor alienante el cual haciendo uso de diferentes estrategias, modifica la conciencia y el afecto de los hijos con el objetivo de destruir sus vínculos psicológicos, afectivos y familiares con el otro progenitor. La violencia en la familia pasa como una situación descuidada, no denunciada por temor a las consecuencias de la misma violencia a la que es sometida; el maltrato fisco y emocional y el abandono se producen en el entorno familiar por parte de los progenitores, cuidadores y familiares mas próximos.Universidad Libre Seccional Socorro - Facultad de derecho y ciencias políticasCurrently, the legislative power of Colombia has aimed to legislate preferentially for the protection of Boys, Girls and Adolescents, establishing as a Constitutional Principle Personal Care, Education, Recreation, Health, Healthy Eating, the right to receive love, The right of children to have a Family and not be separated or violent within it. This is the reason that makes it important for the present legal research work to write about the Parental Alienation Syndrome from now on SAP with the understanding that this is a dysfunction in one of the parents called the alienating parent, which using different strategies, modifies the consciousness and affection of the children in order to destroy their psychological, emotional and family ties with the other parent. Violence in the family passes as a neglected situation, not reported for fear of the consequences of the same violence to which it is subjected; physical and emotional abuse, abandonment occur in the family environment by parents, caregivers and closest relatives

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele