10 research outputs found
Biology and Molecular Biology of \u3ci\u3eIxodes scapularis\u3c/i\u3e
- Publication venue
- ODU Digital Commons
- Publication date
- 01/01/2021
- Field of study
This chapter describes the biology of the tick Ixodes scapularis in relation to its role as the vector of the Lyme disease agent, Borrelia burgdorferi. Following a review of the internal anatomy of the tick, we review basic molecular processes that contribute to an understanding of the dynamics of the tick\u27s specialized parasitic processes, including attachment behavior, salivation; silencing of host anti-inflammatory responses to enable blood ingestion at the dermal feeding site; hemoglobin digestion and reproduction. The chapter is divided into three parts: 1) systematic and anatomical characteristics of ticks; 2) host finding, attachment, salivary disruption of host defenses, blood feeding and digestion; and 3) molecular regulation of tick bodily functions and reproduction. In the first part, we review the systematics of ticks and the taxonomic position of the vector of Lyme disease, I. scapularis, compared to other tick species. Next, we review the general organization of the tick body, including (a) the mouthparts essential for sucking blood, (b) the powerful sucking pharynx, (c) the midgut and its role in blood and hemoglobin digestion, (d) the salivary glands and their complex cellular organization, (e) the synganglion (a fused central nervous system) responsible for controlling all body functions, (f) the reproductive organs, and (g) the tracheal system that facilitates air intake and removal of CO2. In the second part, we highlight the role of the tick\u27s salivary glands in secreting a remarkably complex array of anti-hemostatic molecules that modulate the bite site in the host skin and how these salivary molecules facilitate the lengthy blood-sucking process. We also describe how ticks capture hemoglobin and internalize it in midgut epithelial cells for intracellular digestion, followed by the sequestration of heme into specialized hemosomes for disposal as hematin. We also will review the neural control of regulation of tick salivary glands, blood uptake, hemoglobin digestion, blood meal concentration, water/salt elimination, vitellogenesis and receptor mediated vitellogenin uptake in the developing oocytes and their oviposition
Skeleton of an unusual cat-sized marsupial relative (Metatheria: Marsupialiformes) from the middle Eocene (Lutetian: 44-43 million years ago) of Turkey
- Author
- A Fedorov
- A Goswami
- A Licht
- A. Murat Maga
- Alistair Robert Evans
- AM Candela
- AM Forasiepi
- AM Forasiepi
- AM Forasiepi
- AO Averianov
- B Sigé
- B Van Valkenburgh
- BK McNab
- C Argot
- C Argot
- C Argot
- C Argot
- C Argot
- C Argot
- C Argot
- C de Muizon
- C de Muizon
- C Kurz
- C Kurz
- C Zhang
- C. de Muizon
- C. de Muizon
- C. de Muizon
- C. de Paula Couto
- CL Gordon
- CS Scott
- CV Bennett
- D Koyabu
- DA Arena
- DA Flores
- DA Flores
- DE Wilson
- DL Lofgren
- DM Grossnickle
- E Barrier
- E Coues
- E Gheerbrant
- ED Cope
- EJ Sargis
- ER Dumont
- EV Oliveira
- EV Oliveira
- EV Oliveira
- F Ronquist
- F Ronquist
- F Therrien
- FJ Goin
- FJ Goin
- FS Szalay
- FS Szalay
- FS Szalay
- FS Szalay
- FS Szalay
- FS Szalay
- G Métais
- GG Simpson
- GG Simpson
- GP Wilson
- GP Wilson
- GVR Prasad
- GW Rougier
- GW Rougier
- HE Evans
- HO Elftman
- I Horovitz
- I Horovitz
- I Horovitz
- I Horovitz
- J Kappelman
- J Muirhead
- J Muirhead
- J-Y Crochet
- JA Case
- JA Lillegraven
- JA Lillegraven
- JA Long
- JA Salton
- JD Archibald
- JD Archibald
- JE O'Reilly
- JE Tarver
- JJ Thomason
- JR Wible
- JR Wible
- K Hiiemae
- KA Kermack
- KD Rose
- KE Jones
- KE Sears
- KH Black
- KJ Mitchell
- KJ Travouillon
- L Schmitz
- LG Marshall
- LG Marshall
- LG Marshall
- LG Marshall
- LG Marshall
- LG Marshall
- M Archer
- M Archer
- M Archer
- M Archer
- M Archer
- M Chen
- M dos Reis
- M dos Reis
- M Geiger
- M Godinot
- M Klima
- M Morlo
- M Sánchez-Villagra
- MA Abello
- MA Abello
- MA Nilsson
- MA O'Leary
- MC Maas
- MC Maas
- ME Oliveira
- ME Samuels
- MO Woodburne
- MO Woodburne
- MR Attard
- MR Sánchez-Villagra
- MR Sánchez-Villagra
- MR Sánchez-Villagra
- MR Sánchez-Villagra
- MR Sánchez-Villagra
- N Zimicz
- NM Warburton
- O Erdal
- OA Reig
- OA Reig
- OA Reig
- OLG Buchmann
- ORP Bininda-Emonds
- PF Murray
- PM Butler
- PM Butler
- PO Lewis
- PSL Anderson
- R Lanfear
- R Motani
- RA Pyron
- RC Fox
- RC Fox
- RJ Asher
- RMD Beck
- RMD Beck
- RMD Beck
- RMD Beck
- RMD Beck
- RMD Beck
- Robin M. D. Beck
- RS Voss
- RS Voss
- RW Meredith
- S Bi
- S Echarri
- S Gallus
- S Hillson
- S Sen
- S Van Dyck
- S Wroe
- SE Pavan
- SGB Chester
- SGB Chester
- SM Pellis
- SM Pellis
- SSB Hopkins
- T Smith
- TE Williamson
- TE Williamson
- TJ Myers
- WA Clemens
- WA Clemens
- WA Clemens
- WD Matthew
- WD Turnbull
- WH Osgood
- WK Gregory
- WW Korth
- WW Korth
- WW Roberts
- X Ni
- Z Kielan-Jaworowska
- Z-X Luo
- Ø Hammer
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 16/08/2017
- Field of study
We describe a near-complete, three-dimensionally preserved skeleton of a metatherian (relative of modern marsupials) from the middle Eocene (Lutetian: 44–43 million years ago) Lülük member of the Uzunçarşıdere Formation, central Turkey. With an estimated body mass of 3–4 kg, about the size of a domestic cat (Felis catus) or spotted quoll (Dasyurus maculatus), it is an order of magnitude larger than the largest fossil metatherians previously known from the Cenozoic of the northern hemisphere. This new taxon is characterised by large, broad third premolars that probably represent adaptations for hard object feeding (durophagy), and its craniodental morphology suggests the capacity to generate high bite forces. Qualitative and quantitative functional analyses of its postcranial skeleton indicate that it was probably scansorial and relatively agile, perhaps broadly similar in locomotor mode to the spotted quoll, but with a greater capacity for climbing and grasping. Bayesian phylogenetic analysis of a total evidence dataset comprising 259 morphological characters and 9kb of DNA sequence data from five nuclear protein-coding genes, using both undated and “tip-and-node dating” approaches, place the new taxon outside the marsupial crown-clade, but within the clade Marsupialiformes. It demonstrates that at least one metatherian lineage evolved to occupy the small-medium, meso- or hypo-carnivore niche in the northern hemisphere during the early Cenozoic, at a time when there were numerous eutherians (placentals and their fossil relatives) filling similar niches. However, the known mammal fauna from Uzunçarşıdere Formation appears highly endemic, and geological evidence suggests that this region of Turkey was an island for at least part of the early Cenozoic, and so the new taxon may have evolved in isolation from potential eutherian competitors. Nevertheless, the new taxon reveals previously unsuspected ecomorphological disparity among northern hemisphere metatherians during the first half of the Cenozoic
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
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- Aliaga FA
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- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
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- Antonelli M
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- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
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- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
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- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
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- Arslantas MK
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- Avramidis V
- Ayala LY
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- Baikova VN
- Bakker J
- Balcázar LC
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- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
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- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
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- Baron AV
- Barrachina LG
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- Bassi GL
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- Bianchi I
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- Bianzina S
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- CAPCRI Study
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- Castañeda DP
- Castellana D
- Castellanos A
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- ENVIN-HELICS Study Group
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- FROG ICU Investigators
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Gonçalves B
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- Gordon M
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- Goto T
- Goto T
- Gottlieb J
- Gouveia J
- Gracia RM
- Gradišek P
- Granada RM
- Granados PR
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- Granger CL
- Grangé S
- Grangé S
- Grangé S
- Granillo JF
- Grassi L
- Grasso S
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- Green RS
- Greer M
- Gregory S
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- Grelon F
- Grelon F
- Grevelink M
- Grossestreuer A
- Guanziroli M
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- Guerrero AP
- Guerrero JE
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- Guerrero-López F
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- Guidet B
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- Harm S
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- Hayakawa M
- Hayakawa M
- Hayakawa M
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- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
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- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
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- Herpain A
- Herrera AN
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- Herrera AN
- Herrera AN
- Herrera AN
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- Hewitt H
- Heyne T
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- Hidalgo C
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- Hillier SD
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- Himpe D
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- Hirayama T
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- Hollands S
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- Hoppu S
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- Horvat A
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- Houzé S
- Howes D
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- Hraiech S
- Hravnak M
- Hu HC
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- Hualde JB
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- Huang CH
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- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
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- Ignacio ML
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- Ilan R
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- IPREA Study Group
- Irazabal JM
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- Itenov TS
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- Jacques T
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- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
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- Juez A
- Juliarena A
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
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- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
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- Kara A
- Karachi F
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- Karsten E
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- Kashiya S
- Kashyap R
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- Kawano S
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- Kayambu G
- Kazutoshi F
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- Kirakli C
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- Kirwan CJ
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- Kleinpell R
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- Koco E
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kosuk ME
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- Kox M
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- Krenn CG
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- Kristof J
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- Kruger A
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- Kubota K
- Kuebler WM
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- Kumari BK
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- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Labra C
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- Lafuente E
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- Lukaszewicz AC
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Invasive Circuitry-Based Neurotherapeutics: Stereotactic Ablation and Deep Brain Stimulation for OCD
- Author
- A Pinto
- A Pinto
- AL Benabid
- AL Brody
- AR Gilbert
- B Aouizerate
- B Bandelow
- B Nuttin
- BA Vogt
- BD Greenberg
- BD Greenberg
- BD Greenberg
- BD Greenberg
- BD Greenberg
- BE Lippitz
- Benjamin D Greenberg
- BH Price
- BJ Nuttin
- C Benkelfat
- C Ruck
- CB McCracken
- CB McCracken
- CH Kim
- CJ Murray
- D Denys
- D Denys
- D Denys
- D Denys
- D Ebert
- D Kelly
- D Mataix-Cols
- D Perani
- D Robinson
- DA Malone Jr
- DD Dougherty
- DD Dougherty
- DD Dougherty
- DH Zald
- DH Zald
- DK Binder
- DM Beck
- DR Rosenberg
- DS Husted
- DY Cho
- EB Foa
- EB Montgomery Jr
- ED Huey
- EJ Mufson
- ES Valenstein
- F Corchs
- G Knight
- G Kullberg
- G Nestadt
- G Nestadt
- G Nestadt
- G Steketee
- GR Cosgrove
- GV Sawle
- HC Pan
- HG Westenberg
- HT Ballantine Jr
- J El-Hai
- J Samuels
- JA Yaryura-Tobias
- JD Pressman
- JF Leckman
- JJ Fins
- JJ Fins
- JL Abelson
- JL Eisen
- JL Pool
- JL Vitek
- JM Kemp
- JM Lappin
- JM Schwartz
- JP Cecconi
- JP Hong
- JR Wendland
- JY Chang
- K van Kuyck
- K van Kuyck
- K Van Laere
- KA Kobak
- KT Eddy
- L Baer
- L Gabriels
- L Gabriels
- L Mallet
- LJ Summerfeldt
- LM Koran
- LR Baxter Jr
- M El Mansari
- M Petrides
- M Reimold
- MA Grados
- MA Jenike
- MC Kim
- MC Mancebo
- MC Mancebo
- ME Coles
- ME Mansari
- MH Bloch
- ML Phillips
- MS Okun
- N Kathmann
- N Makris
- N Ozaki
- NA Shapira
- NH Tenney
- NJ van der Wee
- NR McFarland
- OA van den Heuvel
- OCD-DBS Collaborative Group
- P Blier
- P Hay
- P Mindus
- P Mindus
- P Mindus
- PA Cannistraro
- PA Woerdeman
- PD Arnold
- PK Bridges
- PK McGuire
- PR Szeszko
- PR Szeszko
- R Bartha
- R Waziri
- RC Albucher
- RM Cohen
- RP Feldman
- S Bannon
- S Lehericy
- S Saxena
- S Saxena
- S Wilhelm
- SA Rasmussen
- SA Rasmussen
- Scott L Rauch
- SE Stewart
- SE Swedo
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SL Rauch
- SN Haber
- SR Chamberlain
- SR Chamberlain
- SR Chamberlain
- Suzanne N Haber
- T Bingley
- T Herner
- TE Schlaepfer
- W Freeman
- WK Goodman
- WK Goodman
- WM Grill
- XZ Hu
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Psychiatric neurosurgery, specifically stereotactic ablation, has continued since the 1940s, mainly at a few centers in Europe and the US. Since the late 1990s, the resurgence of interest in this field has been remarkable; reports of both lesion procedures and the newer technique of deep brain stimulation (DBS) have increased rapidly. In early 2009, the US FDA granted limited humanitarian approval for DBS for otherwise intractable obsessive-compulsive disorder (OCD), the first such approval for a psychiatric illness. Several factors explain the emergence of DBS and continued small-scale use of refined lesion procedures. DBS and stereotactic ablation have been successful and widely used for movement disorders. There remains an unmet clinical need: current drug and behavioral treatments offer limited benefit to some seriously ill people. Understandings of the neurocircuitry underlying psychopathology and the response to treatment, while still works in progress, are much enhanced. Here, we review modern lesion procedures and DBS for OCD in the context of neurocircuitry. A key issue is that clinical benefit can be obtained after surgeries targeting different brain structures. This fits well with anatomical models, in which circuits connecting orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), basal ganglia, and thalamus are central to OCD pathophysiology and treatment response. As in movement disorders, dedicated interdisciplinary teams, here led by psychiatrists, are required to implement these procedures and maintain care for patients so treated. Available data, although limited, support the promise of stereotactic ablation or DBS in carefully selected patients. Benefit in such cases appears not to be confined to obsessions and compulsions, but includes changes in affective state. Caution is imperative, and key issues in long-term management of psychiatric neurosurgery patients deserve focused attention. DBS and contemporary ablation also present different patterns of potential benefits and burdens. Translational research to elucidate how targeting specific nodes in putative OCD circuitry might lead to therapeutic gains is accelerating in tandem with clinical use
Phosphoinositide 3-Kinases in Health and Disease
- Author
- A Bilancio
- A Cristofano
- A Fougerat
- A Perino
- A Velasco
- AG Bader
- AM Condliffe
- B DeBosch
- B Tigani
- BG Kerfant
- BS Jaiswal
- C Benistant
- C Chaussade
- C Costa
- C Kurlawalla-Martinez
- C Nombela-Arrieta
- C Perrino
- C Perrino
- C Rommel
- C Sadhu
- C Tkaczyk
- CB Knobbe
- CE Edling
- CI Ezeamuzie
- CJ Morrow
- CM Taniguchi
- CR Kahn
- D Chen
- D Liu
- DA Fruman
- DA Fruman
- DC Berwick
- DE Doherty
- DF Barber
- DH Lim
- DJ Gorter
- DT Patton
- E Ciraolo
- E Clayton
- E Hirsch
- E Hirsch
- E Hirsch
- E Patrucco
- ED Harris Jr
- F Damilano
- F Folli
- FM Brennan
- G Chu
- G Condorelli
- G Inoue
- GJ Ferguson
- GK Bandyopadhyay
- H Cho
- H Ji
- H Sano
- HA Rockman
- HS Farghaly
- I Alcazar
- IM Berenjeno
- J Doukas
- J Nakae
- J Shi
- JA Engelman
- JA Marwick
- JA Marwick
- JD Scott
- JE Stelzer
- JJ Nienaber
- JM Agati
- JR McMullen
- JR McMullen
- JS Oak
- K Ali
- K Ali
- K Kotani
- K Liu
- K Okkenhaug
- K Okkenhaug
- K Reif
- K Ueki
- KD Puri
- KD Puri
- KE Bachman
- KG Stenkula
- KK Wong
- KM Hill
- KM Vasudevan
- KS Lee
- L Bai
- L Barberis
- L Bi
- L Liu
- L Zhao
- LC Foukas
- LD Smith
- LH Saal
- LJ Goodyear
- LM Webb
- LR Borlado
- LV Sinclair
- M Bjornholm
- M Camps
- M Conti
- M Gymnopoulos
- M Laffargue
- M Siragusa
- M Takeda
- MA Crackower
- MG Myers
- MG Myers
- MR Bristow
- N Silvestris
- NJ Kerouz
- NR Locke
- OE Brodde
- P Sujobert
- P Voigt
- PR Shepherd
- RB Chagpar
- RC Lin
- RJ Lefkowitz
- RK Mishra
- RT Palframan
- RV Farese
- RV Farese
- S Baraldo
- S Carvalho
- S Chen
- S George
- S Hayer
- S Jia
- S Kang
- S Wee
- SA Omori
- SH Lee
- SM Brachmann
- SO Marx
- ST Jou
- SV Prasad
- SV Prasad
- SV Prasad
- SW Edwards
- T Bohnacker
- T Henley
- T Imamura
- T Maffucci
- T Matsui
- T Okada
- T Phu
- T Sasaki
- T Shioi
- TM Randis
- TT Zhang
- V Pinho
- VA Skeberdis
- VR Sopasakis
- W Duan
- W Link
- XJ Sun
- Y Samuels
- Y Terauchi
- Z Li
- Z Szekanecz
- ZA Knight
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes
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- A Amalraj
- A Jacob
- A Klinkhoff
- A LeGrand
- A Sahebkar
- A Shehzad
- A-MM Fouda
- AA Hemmati
- AA Momtazi
- AA Momtazi-Borojeni
- AM Gonzales
- AR Rahimnia
- B Chandran
- B Kloesch
- B Rahardjo
- B Scott
- B Stockinger
- BY Kang
- C Capini
- C Mauri
- C Mauri
- C Natarajan
- CA Lawson
- CB Larmonier
- CI Daien
- CN Castro
- D Decote-Ricardo
- D Kang
- DJ Newman
- DM Klinman
- DO Moon
- E Abdollahi
- ED Harris Jr
- EHS Choy
- EY Kim
- F Behrens
- F Han
- F Martin
- F Powrie
- FE Lund
- G Huang
- G Kim
- G Ramadan
- GJ Zhao
- GS Firestein
- GY Kim
- H Lee
- H Mirzaei
- H von Boehmer
- HM Zhao
- HS Shin
- HY Hsu
- I de la Torre
- IB McInnes
- J Bruck
- J Krasovsky
- J Samuels
- J-M Zingg
- JCW Edwards
- JD Cañete
- JH Esensten
- JJ Bright
- JJ Chen
- JJ O'shea
- JK Ahn
- JK Kolls
- JM Kyriakis
- JS Smolen
- JS Smolen
- K Handono
- K Kondelkova
- K Mahnke
- K Sugimoto
- K Vanichkul
- K Wing
- K Yudoh
- KA Bush
- KH Lee
- KM Danikowski
- KM Lee
- L Cai
- L Gorelik
- L Klareskog
- L Mathsson
- L Xie
- L Zhang
- M Benderdour
- M Chabaud
- M Chabaud
- M Feldmann
- M Javadi
- M Kusaba
- M Ohno
- M Pilar
- M Shakibaei
- M Teymouri
- M Veldhoen
- M Zhang
- M Zheng
- M-C Boissier
- ME Morgan
- MG Attur
- MJ Park
- MJBM Vervoordeldonk
- MK Jeengar
- MR Ehrenstein
- NA Forward
- NE Street
- NM Rogers
- P Miossec
- P Miossec
- P Ye
- PR Mangan
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- Q Wang
- R Yadav
- RB Lochhead
- RL Coffman
- RS Bhardwaj
- S Bereswill
- S Dolati
- S Ganjali
- S Kanakasabai
- S Kotake
- S Nakae
- S Sakaguchi
- S Sharma
- S Wang
- S-W Oh
- SA Shirley
- SC Gupta
- SC Liang
- SE Sweeney
- SH Chung
- SK Jain
- SS Han
- SS Laev
- T Dorner
- T Korn
- T Matsushita
- TA Barr
- TF Tedder
- TL Stevens
- TR Mosmann
- V Majithia
- VL Heath
- VN Thakare
- W van de Veen
- WB van den Berg
- X Gao
- Y Abe
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- Y Kurebayashi
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
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- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro López B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
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- Radbill Mk
- Rahman St
- Rai Ib
- Raikhel M
- Raissy Hh
- Rajakulasingam K
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- Raphiou Ih
- Rapo Se
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- Słomka A
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- Terracciano L
- Terziev C
- Thomas Ec
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- Tilghman Kg
- Tkachev A
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- Unland M
- Updegrove Jd
- Upham Jw
- Urbonas G
- Urval Kr
- Uusinarkaus Kt
- Vaela R
- Vahed Ya
- Vaicius D
- Valavicius A
- Valdés Cuadrado Lg
- Valiulis A
- Valyon E
- Van Cleeff M
- van den Berg L
- Van Der Berg Bj
- Van der Linden M
- Van Zyl L
- Varano S
- Vebriene J
- Velarde-Mora Hj
- Vertkin Al
- Victorio Cf
- Villasante Fernandez-Montes C
- Visser Ss
- Vlasenko Ma
- Vo Qd
- von Mallinckrodt C
- Vorobeva E
- Vujic T
- Vukcevic M
- Vynnychenko Lb
- Wachter J
- Wainz Rj
- Wakeling Ja
- Wald Ja
- Wall Sj
- Wallner G
- Wan Mohamad Wh
- Wang Cc
- Wasserman Rl
- Waszkuc-Golonko J
- Weber U
- Weberling F
- Wehgartner-Winkler S
- Wei Yf
- Weimer J
- Weinstein Dl
- Welker Ja
- Wellmon B 2nd
- Wells T
- Wenocur Hs
- White Mv
- Wiemer S
- Wijanarko P
- Williams Dl
- Williams Sl
- Win Ph
- Wingo Td
- Winkelmann Ej
- Wisman PP Jr
- Wojciechowska I
- Wyszomierski Da
- Yakushin S
- Yamada Hm
- Yarows S
- Yatsyshyn Ri
- Yeakey Am
- Yu Cy
- Yunger TM Jr
- Yunus F
- Zadionchenko V
- Zaitsev I
- Zakova L
- Zeisler Kh
- Zhebel V
- Zhiglinskaya O
- Zibotics H
- Zidel B
- Ziegner A
- Ziering Rw.
- Zimny Hh
- Ziora D
- Zlatos A
- Zubarenko O
- Zykov K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
The Parathyroids
- Author
- A Berner
- A Carlsson
- A Colarizi
- A Despopoulos
- A Dubin
- A Fanconi
- A Fanconi
- A Fanconi
- A Fanconi
- A Forbes
- A Garner
- A Garner
- A George Di
- A Golden
- A Hodgkinson
- A Hodgkinson
- A Hodgkinson
- A Kölliker
- A Lavender
- A Lichwitz
- A Lorme
- A Mizrahi
- A Nadarajah
- A Pick
- A Prader
- A Prader
- A Schüpbach
- A Sutphin
- A Sutphin
- A Tenenhouse
- A Tenenhouse
- A Tenenhouse
- A Tenenhouse
- A Villamjeva
- AB Borle
- AD Care
- AD Care
- AD Care
- AD Kenny
- AF Carvalheira
- AH Tashijan
- AH Tashjian Jr
- AH Tashjian Jr
- AH Tashjian Jr
- AH Tashjian Jr.
- AH Tashjian Jr.
- AI Katz
- AJ Barrett
- AJ Palubinskas
- AK Solomon
- AM Lawrence
- AM Parfitt
- AS Brickman
- AS Posner
- AS Posner
- AS Posner
- AV Albertini
- AV Kuczerpa
- AW Ireland
- B Beidleman
- B Bücher
- B Castleman
- B Castleman
- B Courvoisier
- B Courvoisier
- B Courvoisier
- B Courvoisier
- B Courvosier
- B Engfeldt
- B Flanagan
- B Flanagan
- B Flanagan
- B Flanagan
- B Frame
- B Frame
- B Frame
- B Halver
- B Isaksson
- B Isaksson
- B Isaksson
- B Isaksson
- B Ostertag
- B Stampl
- BEC Nordin
- BEC Nordin
- BEC Nordin
- BEC Nordin
- BEC Nordin
- BEC Nordin
- BEC Nordin
- BG Howland
- BJB Yim
- BL Munger
- BL Munger
- BL Riggs
- BL Riggs
- BL Riggs
- BL Riggs
- BL Riggs
- BL Samuels
- BM Black
- BM Black
- BM Malloy
- BS Hetzel
- C Arnaud
- C Arnaud
- C Arnaud
- C Arnaud
- C Arnaud
- C Bassett
- C Boonstra
- C Collins-Williams
- C Collins-Williams
- C Friderichsen
- C Hansted
- C Hansted
- C Nagent de
- C Nagent Deuxchaisnes de
- C Paterson
- C Rich
- CA Baud
- CA Mautalen
- CAL Bassett
- CC Capen
- CC Johnston
- CC Johnston Jr.
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CD Arnaud
- CE Boonstra
- CE Dent
- CE Dent
- CE Dent
- CE Dent
- CE Dent
- CE Dent
- CG Bergstrand
- CG Mixter
- CJ Bentzel
- CJ Robinson
- CJ Robinson
- CL Connor
- CR Feind
- CW Cooper
- CYC Pak
- CYC Pak
- CYC Pak
- D Baylink
- D Baylink
- D Baylink
- D Bernstein
- D Boyce
- D Bronsky
- D Lubell
- D McIntosh
- D Paloyan
- D Schachter
- D Smeenk
- DA Cameron
- DA McIntosh
- DA Smith
- DA Smith
- DB Morgan
- DB Morgan
- DB Morgan
- DC Klein
- de Hioco, D., Mira- vet, L.
- DG Harrison
- DG Walker
- DG Walker
- DG Walker
- DG Whedon
- DH Copp
- DH Copp
- DH Copp
- DH Copp
- DH Copp
- DH Mintz
- DJ McCarty
- DJ Prockop
- DJ Prockop
- DJ Prockop
- DJ Reisner
- DJ Simmons
- DL Murphy
- DP Barr
- DR Axelrod
- DR Davies
- DR Wilson
- DS Bernstein
- DS Bernstein
- DS Kushner
- DV Cohn
- DV Kimberg
- DV Kimberg
- E Altenar
- E Bernber
- E Bleuler
- E Böttiger
- E Eisenberg
- E Eisenberg
- E Eisenberg
- E Eisenberg
- E Eisenberg
- E Ellison
- E Grundig
- E Hollunger
- E Kodicek
- E Krokowski
- E Leifer
- E Lomnitz
- E Martin
- E Martin
- E Matthews
- E Mawer
- E Paloyan
- E Paloyan
- E Paloyan
- E Paloyan
- E Reiss
- E Reiss
- E Reiss
- E Reiss
- E Reiss
- E Reiss
- E Rutishauser
- E Schwartz
- E Schwartz
- E Slatopolsky
- E Uehlinger
- E White
- E Yendt
- E Zisman
- EB Olson
- ED Churchill
- Editorial
- EG Duarte
- EGL Bywaters
- EJ Mortell
- EL Krawitt
- EP Scarlett
- ER Yendt
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- M Bielschowsky
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- M Lötz
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- M Winter
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- MA Aliapoulios
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- MacIntyre
- MB Clark
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- O Cope
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- R Ardaillou
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- S Berson
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- T Alajouanine
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- T Reynolds
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- TC Hall
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- TJ Martin
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- TK Gray
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- TN Pullman
- TR Murphy
- TS Danowski
- U Binswanger
- U Binswanger
- U Binswanger
- U Binswanger
- U Binswanger
- U Hachmeister
- UA Libermann
- VH Peden
- VRJ Talmage
- W Braun
- W Hadorn
- W Hung
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- W Neuman
- W Rittel
- W Weinmann
- WA Peck
- WA Peck
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- WC Thomas Jr.
- WC Thomas Jr.
- WE Lassiter
- WF Falls Jr.
- WF Neuman
- WF Neuman
- WG Cushard Jr.
- WG Cushard Jr.
- WG Cushard Jr.
- WH Daughday
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- WP Graham
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- WS Halsted
- WT Goar
- WT Goar
- WW Anderson
- WY Au
- WY Au
- Y Tanaka
- YL Sze
- ZH Chakmakjian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1974
- Field of study
Allgemeine Radiologie und Morphologie der Knochenkrankheiten
- Author
- A Ascenzi
- A Ascenzi
- A Benezowski
- A Benninghoff
- A Benninghoff
- A Bidder
- A Brunschwig
- A Büll
- A Büll
- A Chatelein
- A Engström
- A Engström
- A Fanconi
- A Fonio
- A Gebauer
- A Grassberger
- A Jung
- A Klümper
- A Klümper
- A Leri
- A Lichtwitz
- A Lichtwitz
- A Lichtwitz
- A Liechti
- A Lob
- A Lunderquist
- A Neiss
- A Norman
- A Nussbaum
- A Pinard
- A Pohner
- A Policard
- A Prader
- A Ravelli
- A Schupbach
- A Schüller
- A Schüller
- A Streda
- A Vogt
- A Weiss
- A. Büll
- A. Dhem
- A. Hopf
- AB Rossier
- AC Brower
- AC Brower
- AC Brower
- AH Huggler
- AJ Moos
- AJ Olah
- AJ Olah
- AJ Olah
- Alwens
- AN Jacobs
- AR Winterberger
- AS Posner
- AW Ham
- B Engfeldt
- B Frame
- B Frame
- B Hammer
- B Jacobson
- B Krempien
- B Krempien
- B Kummer
- B Kummer
- B Kummer
- B Madsen
- B Notter
- B Pines
- B Strickland
- B Stöver
- B Vahlquist
- B. DE Bordeaux
- B. Engfeldt
- BA Ashton
- BA Cheney
- BA Cheney
- Bandförmige Osteolysen in den End¬phalangen des Handskeletts
- BE Roberts
- BEC Nordest
- BEC Nordest
- BEC Nordest
- BEC Nordest
- BEC Nordest
- BJ Reilly
- BL Pear
- BL Riggs
- BN Epker
- Bofinger
- C Aeby
- C Reiners
- C Rouiller
- C Rouiller
- C Rouiller
- C Rouiller
- C Sacerdotti
- C-E Lange
- C. A. Baud
- C. Colbert
- C. Deutschländer
- C. Rouiller
- CA Baud
- CA Baud
- CA Baud
- CAL Bassett
- CB Huggins
- CB Huggins
- CB Huggins
- CCM James
- CE Dent
- CE Dent
- CE Dent
- CE Dent
- CE Wheeler
- CG Henny
- CG Mixter
- CH Burnett
- Ch. N. Pease
- Chr. I. Baastrup
- CP Leblond
- D Banzer
- D Carlström
- D Knorr
- D Starck
- D. A. Weber
- D. Carlström
- D. J. Deller
- D. U. Bloor
- DA Cameron
- DA Cameron
- DA Heath
- DA Smith
- DA Smith
- DA Smith
- DA Smith
- DB Foster
- DE Fletcher
- Derivate. Grenzgeb
- DH Carlson
- DH Collins
- DH Copp
- DH Enlow
- DJ Deller
- DJ Deller
- DJ Deller
- DJ McCarty
- DJ McCarty
- DJ McCarty
- DJ McCarty
- DJ McCarty
- DK Harris
- DK Keele
- DL Becker
- DL Berens
- DM Gould
- DR Fraser
- DR Fraser
- E Ambs
- E Ask-Upmark
- E Auerbach
- E Bamberger
- E Barnett
- E Beil
- E Bergmann
- E Bieler
- E Bücheler
- E Ehalt
- E Epple
- E Fischer
- E Fischer
- E Fischer
- E Fischer
- E Fischer
- E Fischer
- E Fischer
- E Fukada
- E Gardner
- E Güntz
- E Hausmann
- E Hayek
- E Hayek
- E Hayek
- E Hipp
- E Ikkala
- E Klein
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Krokowski
- E Kruner
- E Kübler
- E Lachman
- E Letterer
- E Looser
- E Looser
- E Looser
- E Looser
- E Manzke
- E May
- E Morscher
- E Morscher
- E Morscher
- E Müller
- E Münchmeyer
- E Neumann
- E Passarge
- E Peter
- E Ritz
- E Ritz
- E Ritz
- E Ritz
- E Rohner
- E Rutishauser
- E Rutishauser
- E Rutishauser
- E Rutishauser
- E Schwarz
- E Schwarz
- E Sieber
- E Silinkovä-Malkova
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E Uehlinger
- E. Bonucci
- E. Borcke
- E. G. Bell
- E. Schulmann
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- El Wilke
- EM Alhava
- EP Clerkin
- ER Kutz
- F Albright
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- F Heuck
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- F Holzer
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- F Kainberger
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- F Norgaabd
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- F Polgar
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- F Rehbein
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- F Schajowicz
- F Schilling
- F Schilling
- F Schmid
- F Schmid
- F Sommer
- F Sommer
- F Sommer
- F Strauscheid
- F Wassermann
- F. G. Evans
- F. H. Doyle
- F. Heuck
- F. Heuck
- F. Heuck
- F. K. Herbert
- FC Bartter
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- FO Ward
- FR Johnson
- FR Johnson
- Frakturnagelung und Verschraubung aus mor-phologischer Sicht. Langenb
- FW Rathke
- FW Retttter
- G Axhausen
- G Brandt
- G Chapchal
- G Delling
- G Edström
- G Engelmann
- G Fanconi
- G Glogowski
- G Hartmann
- G Hauberg
- G Hegemann
- G Heuck
- G Jentschura
- G Jentschura
- G Jentschura
- G Juliane
- G Kindermann
- G Köteles
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- G Küntscher
- G Lemke
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- G Liess
- G Liess
- G Luska
- G Mignani
- G Möbius
- G Nichols
- G Pliess
- G Pliess
- G Pliess
- G Pommer
- G Pommer
- G Sassen
- G Schallock
- G Schmitt
- G Schmorl
- G Schmorl
- G Schwalbe
- G Simon
- G Sitbramanian
- G Sitbramanian
- G Spiegler
- G Stein
- G Vaes
- G Veltman
- G Vose
- G Wiberg
- G Wiseman
- G-. Ritchie
- G. Miyakawa
- G. P Vose
- G. Reischle
- GA Sedgenidse
- Garn St. M. Pao, E. N., Rihl, M. E.
- GB Greenfield
- GB Greenfield
- GCH Bauer
- GD Steven
- GD Whedon
- GE Hosking
- GG Zesas
- GH Bourne
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- GH Schmitt
- GM Lösch
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- GP Vose
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- GV Foster
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- GW Heimann
- GW Nixon
- H Althoff
- H Assmann
- H Assmann
- H Assmann
- H Babo Von
- H Bartelheimer
- H Bartelheimer
- H Bartelheimer
- H Bartelheimer
- H Bartelheimer
- H Bartelheimer
- H Beckmann
- H Biermann
- H Braun
- H Böhme
- H Büchner
- H Contzen
- H Cotta
- H Creutzig
- H Creutzig
- H Ellegast
- H Ellegast
- H Ellegast
- H Ellegast
- H Ellegast
- H Ellegast
- H Ellegast
- H Ellegast
- H Fleisch
- H Fleisch
- H Gajewski
- H Geiger
- H Harnasch
- H Heitzeberg
- H Hellner
- H Hellner
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- H Hellner
- H Jesserer
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- H Jesserer
- H Junge
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- H Konermann
- H Kraft
- H Laake
- H Linke
- H Lossen
- H Mau
- H Mau
- H Mau
- H Mau
- H Mau
- H McHenry
- H Molzberger
- H Mühr
- H Müller-Bergh
- H Netter
- H Oberdalhoff
- H Quintar
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- H Rasmussen
- H Rasmussen
- H Rasmussen
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- H Rasmussen
- H Reinwein
- H Reinwein
- H Rohling
- H Sack
- H Sack
- H Sack
- H Sack
- H Salinger
- H Schilling
- H Schmidberger
- H Schmidt
- H Schmidt
- H Schmidt
- H Schober
- H Selye
- H Serre
- H Simon
- H Spiess
- H Steim
- H Triepel
- H Tschumi
- H Uthgenannt
- H Wagner
- H Wagner
- H Wagner
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- York-Toronto-London
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1976
- Field of study