Luminescence dating and mineralogical investigations of bricks from erikli basilica in Stratonikeia ancient city (SW-Turkey)

Stratonikeia is one of the oldest settlements in southwestern Anatolia and at the same time significant for an understanding of the Hellenistic period. Archaeological records of Stratonikeia date back to around 2000 BC. This study provides new information not only about luminescence age but also about mineralo-petrographic, geochemical characteristics of bricks taken from Erikli Basilica in Stratonikeia (Turkey). In this study, mineralogical data of TL and OSL dating of two bricks and two sediment samples will be presented. The bricks have highly similar mineralogical composition, consisting mainly of quartz and muscovite. These results are supported by XRD studies. In order to perform the thermoluminescence (TL) and optically stimulated luminescence (OSL) dating, the equivalent dose (ED) and the annual dose (AD) of the samples were determined using different estimation techniques. The TL ages of bricks are determined to be 1189±89 and 576±40 years. The IRSL ages of the bricks are determined to be 1167±85 years and 545±50 years. Additionally, supporting the TL and IRSL ages, the OSL quartz ages of the two sediments obtained from the top of the layer under the floor are discovered to be about 1100 years. Mineralo-petrographic, geochemical, dating and archaeological studies have revealed that the age of bricks is different from each other. Furthermore, Erikli Basillica was built in bricks, consisting of raw materials taken from different quarries in different periods. Within the framework, the first report of the experimental approach has been published from Stratonikeia archaeological site located in Muğla, Agean Anatolia. © 2018 MAA Open Access. Printed in Greece. All rights reserved

The stochastic digital human is now enrolling for in silico imaging trials -- Methods and tools for generating digital cohorts

Randomized clinical trials, while often viewed as the highest evidentiary bar by which to judge the quality of a medical intervention, are far from perfect. In silico imaging trials are computational studies that seek to ascertain the performance of a medical device by collecting this information entirely via computer simulations. The benefits of in silico trials for evaluating new technology include significant resource and time savings, minimization of subject risk, the ability to study devices that are not achievable in the physical world, allow for the rapid and effective investigation of new technologies and ensure representation from all relevant subgroups. To conduct in silico trials, digital representations of humans are needed. We review the latest developments in methods and tools for obtaining digital humans for in silico imaging studies. First, we introduce terminology and a classification of digital human models. Second, we survey available methodologies for generating digital humans with healthy and diseased status and examine briefly the role of augmentation methods. Finally, we discuss the trade-offs of four approaches for sampling digital cohorts and the associated potential for study bias with selecting specific patient distributions

ROC study of the effect of stereoscopic imaging on assessment of breast lesions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135047/1/mp0172.pd

An observer study comparing spot imaging regions selected by radiologists and a computer for an automated stereo spot mammography technique

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134832/1/mp7492.pd

Effects of magnification and zooming on depth perception in digital stereomammography: an observer performance study

We are evaluating the application of stereoscopic imaging to digital mammography. In the current study, we investigated the effects of magnification and zooming on depth perception. A modular phantom was designed which contained six layers of 1-mm-thick Lexan plates, each spaced 1 mm apart. Eight to nine small, thin nylon fibrils were pasted on each plate in horizontal or vertical orientations such that they formed 25 crossing fibril pairs in a projected image. The depth separation between each fibril pair ranged from 2 to 10 mm. A change in the order of the Lexan plates changed the depth separation of the two fibrils in a pair. Stereoscopic image pairs of the phantom were acquired with a GE full-field digital mammography system. Three different phantom configurations were imaged. All images were obtained using a Rh target/Rh filter spectrum at 30 kVp tube potential and a ±3° stereo shift angle. Images were acquired in both contact and 1.8X magnification geometry and an exposure range of 4 to 63 mAs was employed. The images were displayed on a Barco monitor driven by a Metheus stereo graphics board and viewed with LCD stereo glasses. Five observers participated in the study. Each observer visually judged whether the vertical fibril was in front of or behind the horizontal fibril in each fibril pair. It was found that the accuracy of depth discrimination increased with increasing fibril depth separation and x-ray exposure. The accuracy was not improved by electronic display zooming of the contact stereo images by 2X. Under conditions of high noise (low mAs) and small depth separation between the fibrils, the observers' depth discrimination ability was significantly better in stereo images acquired with geometric magnification than in images acquired with a contact technique and displayed with or without zooming. Under our experimental conditions, a 2 mm depth discrimination was achieved with over 60% accuracy on contact images with and without zooming, and with over 90% accuracy on magnification images. This study indicates that stereoscopic imaging, especially with magnification, may be useful for visualizing the spatial distribution of microcalcifications in a cluster and for differentiating overlapping tissues from masses on mammograms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48976/2/pmb3_22_007.pd

COVID-19 pandemic and allergen immunotherapy—an EAACI survey

Background: As in many fields of medical care, the coronavirus disease 2019 (COVID-19) resulted in an increased uncertainty regarding the safety of allergen immunotherapy (AIT). Therefore, the European Academy of Allergy and Clinical Immunology (EAACI) aimed to analyze the situation in different countries and to systematically collect all information available regarding tolerability and possible amendments in daily practice of sublingual AIT (SLIT), subcutaneous AIT (SCIT) for inhalant allergies and venom AIT. Methods: Under the framework of the EAACI, a panel of experts in the field of AIT coordinated by the Immunotherapy Interest Group set-up a web-based retrospective survey (SurveyMonkey®) including 27 standardized questions on practical and safety aspects on AIT in worldwide clinical routine. Results: 417 respondents providing AIT to their patients in daily routine answered the survey. For patients (without any current symptoms to suspect COVID-19), 60% of the respondents informed of not having initiated SCIT (40% venom AIT, 35% SLIT) whereas for the maintenance phase of AIT, SCIT was performed by 75% of the respondents (74% venom AIT, 89% SLIT). No tolerability concern arises from this preliminary analysis. 16 physicians reported having performed AIT despite (early) symptoms of COVID-19 and/or a positive test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Conclusions: This first international retrospective survey in atopic diseases investigated practical aspects and tolerability of AIT during the COVID-19 pandemic and gave no concerns regarding reduced tolerability under real-life circumstances. However, the data indicate an undertreatment of AIT, which may be temporary, but could have a long-lasting negative impact on the clinical care of allergic patients