Influence of different treatment techniques on radiation dose to the LAD coronary artery

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Getting ready to use control:Advances in the measurement of young children's use of proactive control

A key developmental transition in executive function is in the temporal dynamics of its engagement: children shift from reactively calling to mind task-relevant information as needed, to being able to proactively maintain information across time in anticipation of upcoming demands. This transition is important for understanding individual differences and developmental changes in executive function; however, methods targeting its assessment are limited. We tested the possibility that Track-It, a paradigm developed to measure selective sustained attention, also indexes proactive control. In this task children must track a target shape as it moves unpredictably among moving distractors, and identify where it disappears, which may require proactively maintaining information about the target or goal. In two experiments (5-6 year-olds, Ns = 33, 64), children's performance on Track-It predicted proactive control across two established paradigms. These findings suggest Track-It measures proactive control in children. Theoretical possibilities regarding how proactive control and selective sustained attention may be related are also discussed

Resource Reservation in Advance in Heterogeneous Networks with Partial ATM Infrastructures

Resource reservation in advance (ReRA) enables scheduling and allocation of resources at an early stage in time. This way, the availability of resources can actually be guaranteed for the point in time when the resources are needed. As opposed to that, current reservation protocols such as RSVP perform an "immediate" reservation without advance scheduling. They can therefore suffer shortage of resources with subsequent rejection of applications. This paper describes our new approach for providing resource reservation in advance in ATM networks. As a foundation, we first present experiences of IPng and RSVP over ATM. Based on this work, we then discuss major design issues of an appropriate ReRA solution. Important aspects are the signalling model for ReRA, the admission control strategy, the duration of connections, and various other time-related parameters. We also discuss our ongoing implementation of ReRA as an extension of RSVP and outline directions for future research in this area..

Internetworking over ATM: Experiences with IP/ IPng and RSVP

This paper describes recent experiences with evaluating and implementing advanced internetwork communication protocols on top of ATM. First, performance results with conventional TCP/IP over ATM based on Digital Equipment's Gigaswitch /ATM are reported. It becomes obvious that current protocols must be tuned specifically in order to exploit ATM performance. In order to address advanced quality of service issues based on resource reservation, the paper describes an implementation of IPng (IP next generation) and RSVP (Resource Reservation Protocol) over ATM. Solutions for mapping quality of service and traffic parameters in an adequate way are presented. Moreover, the issue of address mapping from IPng onto ATM is discussed. Implementation results and experiences in these areas are illustrated. Finally, ongoing current work on resource reservation in advance is presented. It is outlined that longer-term resource planning and scheduling provides additional benefits for selected ATM appli..

Dose-volume histogram for the left anterior descending coronary artery with the 7-field IMRT technique in the intermediate target volume scenario

<p><b>Copyright information:</b></p><p>Taken from "Influence of different treatment techniques on radiation dose to the LAD coronary artery"</p><p>http://www.ro-journal.com/content/2/1/20</p><p>Radiation Oncology (London, England) 2007;2():20-20.</p><p>Published online 5 Jun 2007</p><p>PMCID:PMC1892030.</p><p></p

Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy

Arrhythmia-induced cardiomyopathy (AIC) is characterized by left-ventricular systolic dysfunction caused by persistent arrhythmia. To date, genetic or pathological drivers causing AIC remain unknown. Here, we generated induced pluripotent stem cells (iPSCs) from an AIC patient. The AIC-iPSCs exhibited full pluripotency and differentiation characteristics and maintained a normal karyotype after reprogramming. The AIC-iPSCs differentiated into functional beating AIC-iPSCcardiomyocytes (CMs), which represents the cell-type of interest to study molecular, genetic and functional aspects of AIC

Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases: an Augsburg University Medical Center experience

Purpose!#!External-beam radiotherapy (EBRT) is the predominant method for localized brain radiotherapy (LBRT) after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50-kV x‑rays is an alternative way to focally irradiate the resection cavity after BM surgery, with the option of shortening the overall treatment time and limiting normal tissue irradiation.!##!Methods!#!We retrospectively analyzed the outcomes of all patients who underwent neurosurgical resection of BM and 50-kV x‑ray IORT between 2013 and 2020 at Augsburg University Medical Center.!##!Results!#!We identified 40 patients with 44 resected BM treated with 50-kV x‑ray IORT. Median diameter of the resected metastases was 2.8 cm (range 1.5-5.9 cm). Median applied dose was 20 Gy. All patients received standardized follow-up (FU) including 3‑monthly MRI of the brain. Mean FU was 14.4 months, with a median MRI FU for alive patients of 12.2 months. Median overall survival (OS) of all treated patients was 26.4 months (estimated 1‑year OS 61.6%). The observed local control (LC) rate of the resection cavity was 88.6% (estimated 1‑year LC 84.3%). Distant brain control (DC) was 47.5% (estimated 1‑year DC 33.5%). Only 25% of all patients needed WBI in the further course of disease. The observed radionecrosis rate was 2.5%.!##!Conclusion!#!IORT with 50-kV x‑rays is a safe and appealing way to apply LBRT after neurosurgical resection of BM, with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early