Estudio termodinámico sobre la mineralogénesis de la Galena en la Mina de Cierco (Alta Ribagorza)

Se efectha un estudio de la mineralogénesis de la galena en la mina de Cierco (Alta Riborgaza). Se determina a partir de cálculos termodinamicos la solubilidad de la galena en una solución hidrotermal a 150°C y 3 molal de NaCl y se estudian los efectos de los diferentes posibles agentes  precipitantes. A partir de las mineralizaciones que acompañan a la galena, del conocimiento que se dispone de las inclusiones presentes en las mineralizaciones se efectúan posibles hipótesis sobre la formación del yacimiento

Estudio termodinámico sobre la mineralogénesis de la Galena en la Mina de Cierco (Alta Ribagorza)

Se efectha un estudio de la mineralogénesis de la galena en la mina de Cierco (Alta Riborgaza). Se determina a partir de cálculos termodinamicos la solubilidad de la galena en una solución hidrotermal a 150°C y 3 molal de NaCl y se estudian los efectos de los diferentes posibles agentes  precipitantes. A partir de las mineralizaciones que acompañan a la galena, del conocimiento que se dispone de las inclusiones presentes en las mineralizaciones se efectúan posibles hipótesis sobre la formación del yacimiento

The crystal structure of lead (II) indium (III) chalcogenide: PbIn2S4, a synthetic phase closely related to the lillianite group

PbIn2S4, Mr. =565.1, orthorhombic, Pnma, a = 11.675 (2), b =3.848(l), c =13.754(3) A, Z =4,Dm =Dc=6.1g.cm -3  F(000) =976,,u (Moka) = 363 cm-1. The structure was solved by heavy atom method and refined by blockdiagonal least-squares method to a fmal R =0.057 for all observed reflections. The lead and indium atoms have a distorted 8 and 6  coordination, respectively. This synthetic phase is closely related to the lillianite group. Avera e bond lengths in PbIn2S4 are: Pb-S 3.08 (3) and In-S 2.63 (4) A

Complexes of Pd(II) and Pt(II) with 9-Aminoacridine: Reactions with DNA and Study of Their Antiproliferative Activity

Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2 · 2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L = PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction of 9-aminoacridine and the complex [PtCl2(DMSO2]. The capacity of the compounds to modify the secondary and tertiary structures of DNA was evaluated by means of circular dichroism and electrophoretic mobility. Both palladium and platinum compounds proved active in the modification of both the secondary and tertiary DNA structures. AFM images showed noticeable modifications of the morphology of the plasmid pBR322 DNA by the compounds probably due to the intercalation of the complexes between base pairs of the DNA molecule. Finally, the palladium complex was tested for antiproliferative activity against three different human tumor cell lines. The results suggest that the palladium complex of formula [Pd(9AA)(μ-Cl)]2 has significant antiproliferative activity, although it is less active than cisplatin

Pd(II) and Pt(II) Complexes of Schiff Thiobases Derived From 2-Carbonylpyridine

Pd(ll) and Pt(ll) complexes of three series of Schiff thiobases derived from 2- carbonylpyridine have been synthesized and characterized. The crystal structure of the Pt(ll) derivative of methyl-3-(2-pyridylmethylene)hydrazinecarbodithioate (HFp) was resolved. The ligand coordinates the platinum ion in tridentate fashion by heterocycle and imine nitrogen and thiocarbonyl sulfur. The fourth ligand is a chloride ion. The structure of the complexes is suitable for the formation of monofunctional adducts with DNA. Studies on the interaction of the complexes with Calf thymus DNA by CD reveal modifications in the B form of lineal DNA. Interaction with plasmid DNA was also confirmed in the images obtained by atomic force microscopy

Bimetallic derivatives of the [M(en)3]3+ ion (M=Cr and Co): A series of compounds with unusual magnetic and structural properties (abstract)

Under the terms of the Creative Commons Attribution (CC BY) license to their work.The crystal structure and magnetic susceptibility of a series of [M(en)3]3+ (M=Cr or Co) derivatives are described. In particular, the crystalline structures of (1) [Cr(en) 3]3[FeCl6]Cl6·H2O, (2) [Co(en)3]3[FeCl6]Cl6· H2O, and (3) [Cr(en)3][FeCl6]·11H 2O are reported. Structural data, in Å, for these compounds are as follows: (1) space group R3, a=15.447(4), c=21.060(6), Z=3; (2) space group R3, a=15.346(3), c=20.880(5), Z=3; (3) space group P3c1, a=11.654(3), c=15.508(4), Z=2. The main structural feature of the first two isomorphous materials is that they consist of a three-dimensional network of triangular antiprisms formed by the [M(en)3]3+ (M=Cr or Co) ions and connected with each other by sharing corners. An [FeCl 6]3- ion is placed at the center of each antiprism. Compound (3) contains a sc arrangement of [Cr(en)3] 3+ and [FeCl6]3- octahedra. In addition, the magnetic susceptibilities of the above-mentioned isomorphous compounds and of [M(en)3][FeCl6] (M=Cr and Co) and [Cr(en)3][InCl6] are reported. While [Cr(en) 3]3[FeCl6]Cl6·H2O orders as a ferrimagnet at 0.91 K, [Cr(en)3][FeCl6] exhibits antiferromagnetic properties with Tc=2.26 K, a temperature rather similar to the antiferromagnetic ordering temperature of [Co(en) 3][FeCl6].Peer Reviewe

Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity

Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2 · 2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L = PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction of 9-aminoacridine and the complex [PtCl2(DMSO)2]. The capacity of the compounds to modify the secondary and tertiary structures of DNA was evaluated by means of circular dichroism and electrophoretic mobility. Both palladium and platinum compounds proved active in the modification of both the secondary and tertiary DNA structures. AFM images showed noticeable modifications of the morphology of the plasmid pBR322 DNA by the compounds probably due to the intercalation of the complexes between base pairs of the DNA molecule. Finally, the palladium complex was tested for antiproliferative activity against three different human tumor cell lines. The results suggest that the palladium complex of formula [Pd(9AA)(μ-Cl)]2 has significant antiproliferative activity, although it is less active than cisplatin