Experimental Verification of Modal Identification of a High-rise Building Using Independent Component Analysis

Abstract Independent component analysis is one of the linear transformation methods based the techniques for separating blind sources from the output signals of the system. Recently, the method has been analytically applied to the identification of mode shapes and modal responses from the output signal of structures. This study aims to experimentally validate the blind source separation using ICA method and propose a novel method for identification of the modal parameters from the decomposed modal responses. The result of the experimental testing on the three-story steel scale model shows that the mode shapes obtained by ICA method are in good agreement with those by the analytical and peak-picking method in the frequency domain. Based on the robust mathematical model, ICA can calculate the natural frequency and damping ratio effectively using the probability distribution function of the instantaneous natural frequency determined by Hilbert transform of the decomposed modal responses and the change in the output covariance. Finally, the validity of the proposed method paves the way for more effective output-only modal identification for assessment of existing steel-concrete buildings

Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease

Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs. The key pathogenic mechanisms associated with AERD are the overproduction of cysteinyl leukotrienes (CysLTs) and increased CysLTR1 expression in the airway mucosa and decreased lipoxin and PGE2 synthesis. Genetic studies have suggested a role for variability of genes in disease susceptibility and the response to medication. Potential genetic biomarkers contributing to the AERD phenotype include HLA-DPB1, LTC4S, ALOX5, CYSLT, PGE2, TBXA2R, TBX21, MS4A2, IL10, ACE, IL13, KIF3A, SLC22A2, CEP68, PTGER, and CRTH2 and a four-locus SNP set composed of B2ADR, CCR3, CysLTR1, and FCER1B. Future areas of investigation need to focus on comprehensive approaches to identifying biomarkers for early diagnosis

Ever-Evolving Memory by Blending and Refining the Past

For a human-like chatbot, constructing a long-term memory is crucial. However, current large language models often lack this capability, leading to instances of missing important user information or redundantly asking for the same information, thereby diminishing conversation quality. To effectively construct memory, it is crucial to seamlessly connect past and present information, while also possessing the ability to forget obstructive information. To address these challenges, we propose CREEM, a novel memory system for long-term conversation. Improving upon existing approaches that construct memory based solely on current sessions, CREEM blends past memories during memory formation. Additionally, we introduce a refining process to handle redundant or outdated information. Unlike traditional paradigms, we view responding and memory construction as inseparable tasks. The blending process, which creates new memories, also serves as a reasoning step for response generation by informing the connection between past and present. Through evaluation, we demonstrate that CREEM enhances both memory and response qualities in multi-session personalized dialogues.Comment: 17 pages, 4 figures, 7 table

Use of Inhaled Iloprost in an Infant With Bronchopulmonary Dysplasia and Pulmonary Artery Hypertension

Pulmonary artery hypertension is a common cardiovascular complication in preterm infants with bronchopulmonary dysplasia which is associated with increased morbidity and mortality. Inhaled iloprost is used as a therapeutic option in pulmonary hypertension, especially in adults. There have been but a few reports on the use of iloprost for neonates and infants. We report the case of a 5 month-old-male infant who received neonatal intensive care for 4 months due to respiratory distress syndrome and prematurity, during which he developed bronchopulmonary dysplasia. Echocardiography showed severe pulmonary hypertension. The initial treatment included respiratory support with high frequency oscillatory ventilation (HFOV); however, his clinical condition did not improve. Inhaled iloprost with sildenafil, an oral phosphodiesterase-5 inhibitor, was thus used. With the administration of iloprost and sildenafil, his condition improved and he was weaned from oxygen. Our clinical experience suggests that iloprost is a promising therapy for pulmonary hypertension, especially when inhaled nitric oxide is unavailable

Retrieval of an embolization coil accidentally dislodged in the descending aorta of a dog with a patent ductus arteriosus

A 3.5-year-old intact female miniature poodle (weighing 2.7 kg) was referred to the Veterinary Teaching Hospital at Kangwon National University, because of inadvertent aortic embolization, by an occlusion coil used for the closure of patent ductus arteriosus (PDA). The coil was found at the site of the branching renal arteries in the abdominal aorta. A foreign body forceps with a three-wire nail tip was used, with fluoroscopic guidance, to retrieve the coil. After the removal, the dog was treated with heparin to prevent thromboembolization

Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells.

ABSTRACT 2-Arachidonyl-glycerol (2-Ara-Gl) recently was identified as a putative endogenous ligand for cannabinoid receptor types CB1 and CB2 by competitive binding. More recent immune function assays demonstrated that 2-Ara-Gl possessed immunomodulatory activity. Because several plant-derived cannabinoids inhibit interleukin-2 (IL-2) expression, 2-Ara-Gl was investigated for its ability to modulate this cytokine. The direct addition of 2-Ara-Gl to mouse splenocyte cultures suppressed phorbol-12-myristate-13-acetate plus ionomycin-induced IL-2 secretion and steady state mRNA expression in a dose-dependent manner. 2-Ara-Gl also produced a marked inhibition of IL-2 promotor activity as determined by transient transfection of EL4.IL-2 cells with a pIL-2-CAT construct. 2-Ara-Gl at 5, 10, 20, and 50 M suppressed phorbol-12-myristate-13-acetate plus ionomycin-induced IL-2 promotor activity by 18%, 28%, 39%, and 54%, respectively. To further characterize the mechanism for the transcriptional regulation of IL-2 by 2-Ara-Gl, the DNA-binding activity of transcription factors, nuclear factor of activated T cells (NF-AT), nuclear factor for immunoglobulin chain in B cells (NF-B/Rel), activator protein-1(AP-1), octamer, and cAMP-response element binding protein was evaluated by electrophoretic mobility shift assay in mouse splenocytes. In addition, a reporter gene expression system for p(NF-B) 3 -CAT, p(NF-AT) 3 -CAT, and p(AP-1) 3 -CAT was used in transiently transfected EL4.IL-2 cells to determine the effect of 2-Ara-Gl on promoter activity for each of the specific transcription factors. 2-Ara-Gl reduced both the NF-AT-binding and promoter activity in a dose-dependent manner and, to a lesser degree, NF-B/Rel-binding and promoter activity. No significant effect was observed on octamer-and cAMP-response element-binding activity. AP-1 DNA-binding activity was not inhibited by 2-AraGl, but a modest inhibition of promoter activity was observed