1,809 research outputs found
Implications of skill-biased technological change: international evidence
Demand for less skilled workers decreased dramatically in the US and in other developed countries over the past two decades. WE argue that pervasive skill-biased technological change, rather than increased trade with the development world, is the principal culprit. The pervasiveness of this technological change is important for two reasons. Firstly, it is an immediate and testable implication of technological change. Secondly, under standard assumptions, the more pervasive the skill-biased technological, the greater the increase in the embodied supply of less skilled workers and the greater the increase in the embodied supply if less skilled workers and the greater the increases in the embodied supply of less skilled workers and the greater the depressing effect on their relative wages through world goods prices. In contrast, in the Heckscher-Ohlin model with small open economies the skill-bias of local technological changes does not affect wages. Thus, pervasiveness deals with a major criticism of skill-biased technological as a cause. Testing the implications of pervasive, skill-biased technological change, we find strong supporting evidence. Firstly, across the OECD, most industries have increased the proportion of skilled workers employed, despite rising or stable relative wages. Secondly, increases in demand for skills were concentrated in the same manufacturing industries in different developed countries
Market regulation and firm performance: the case of smoking bans in the UK
This paper analyzes the effects of a ban on smoking in public places upon firms and
consumers. It presents a theoretical model and tests its predictions using unique data from
before and after the introduction of smoking bans in the UK. Cigarette smoke is a public bad,
and smokers and non-smokers differ in their valuation of smoke-free amenities. Consumer
heterogeneity implies that the market equilibrium may result in too much uniformity, whereas
social optimality requires a mix of smoking and non-smoking pubs (which can be
operationalized via licensing). If the market equilibrium has almost all pubs permitting
smoking (as is the case in the data) then a blanket ban reduces pub sales, profits, and
consumer welfare. We collect survey data from public houses and find that the Scottish
smoking ban (introduced in March 2006) reduced pub sales and harmed medium run
profitability. An event study analysis of the stock market performance of pub-holding
companies corroborates the negative effects of the smoking ban on firm performance
Economics of education research: a review and future prospects
In this paper we offer an appraisal of the economics of education research area, charting its history as a field and discussing the ways in which economists have contributed both to education research and to education policy-making. In particular, we highlight the theoretical and methodological contributions that economists have made to the field of education during the last 50 years. Despite the success of the economics of education as a field of inquiry, we argue that some of the contributions made by economists could be limited if the economics of education is seen as quite distinct from the other disciplines working in the field of education. In these areas of common interest, economists need to work side by side with the other major disciplines in the field of education if their contribution to the field is to be maximised, particularly in terms of applying improved methodology. We conclude that the study of education acquisition and its economic and social impact in the economics of education research area is very likely to remain a fertile research ground. Acknowledgement
Floppy swimming: Viscous locomotion of actuated elastica
Actuating periodically an elastic filament in a viscous liquid generally
breaks the constraints of Purcell's scallop theorem, resulting in the
generation of a net propulsive force. This observation suggests a method to
design simple swimming devices - which we call "elastic swimmers" - where the
actuation mechanism is embedded in a solid body and the resulting swimmer is
free to move. In this paper, we study theoretically the kinematics of elastic
swimming. After discussing the basic physical picture of the phenomenon and the
expected scaling relationships, we derive analytically the elastic swimming
velocities in the limit of small actuation amplitude. The emphasis is on the
coupling between the two unknowns of the problems - namely the shape of the
elastic filament and the swimming kinematics - which have to be solved
simultaneously. We then compute the performance of the resulting swimming
device, and its dependance on geometry. The optimal actuation frequency and
body shapes are derived and a discussion of filament shapes and internal
torques is presented. Swimming using multiple elastic filaments is discussed,
and simple strategies are presented which result in straight swimming
trajectories. Finally, we compare the performance of elastic swimming with that
of swimming microorganisms.Comment: 23 pages, 6 figure
Experimental Investigations of Elastic Tail Propulsion at Low Reynolds Number
A simple way to generate propulsion at low Reynolds number is to periodically
oscillate a passive flexible filament. Here we present a macroscopic
experimental investigation of such a propulsive mechanism. A robotic swimmer is
constructed and both tail shape and propulsive force are measured. Filament
characteristics and the actuation are varied and resulting data are
quantitatively compared with existing linear and nonlinear theories
Sample sizes for cancer trials where Health Related Quality of Life is the primary outcome
Health Related Quality of Life (HRQoL) instruments are increasingly important in evaluating health care, especially in cancer trials. When planning a trial, one essential step is the calculation of a sample size, which will allow a reasonable chance (power) of detecting a pre-specified difference (effect size) at a given level of statistical significance. It is almost mandatory to include this calculation in research protocols. Many researchers quote means and standard deviations to determine effect sizes, and assume the data will have a Normal distribution to calculate their required sample size. We have investigated the distribution of scores for two commonly used HRQoL instruments completed by lung cancer patients, and have established that scores do not have the Normal distribution form. We demonstrate that an assumption of Normality can lead to unrealistically sized studies. Our recommendation is to use a technique that is based on the fact that the HRQoL data are ordinal and makes minimal but realistic assumptions. © 2000 Cancer Research Campaig
The role of body rotation in bacterial flagellar bundling
In bacterial chemotaxis, E. coli cells drift up chemical gradients by a
series of runs and tumbles. Runs are periods of directed swimming, and tumbles
are abrupt changes in swimming direction. Near the beginning of each run, the
rotating helical flagellar filaments which propel the cell form a bundle. Using
resistive-force theory, we show that the counter-rotation of the cell body
necessary for torque balance is sufficient to wrap the filaments into a bundle,
even in the absence of the swirling flows produced by each individual filament
Synchronization of active mechanical oscillators by an inertial load
Motivated by the operation of myogenic (self-oscillatory) insect flight
muscle, we study a model consisting of a large number of identical oscillatory
contractile elements joined in a chain, whose end is attached to a damped
mass-spring oscillator. When the inertial load is small, the serial coupling
favors an antisynchronous state in which the extension of one oscillator is
compensated by the contraction of another, in order to preserve the total
length. However, a sufficiently massive load can sychronize the oscillators and
can even induce oscillation in situations where isolated elements would be
stable. The system has a complex phase diagram displaying quiescent,
synchronous and antisynchrononous phases, as well as an unsual asynchronous
phase in which the total length of the chain oscillates at a different
frequency from the individual active elements.Comment: 5 pages, 4 figures, To appear in Phys. Rev. Let
Nonlinear instability in flagellar dynamics: a notel modulation mechanism in sperm migration
Throughout biology, cells and organisms use flagella and cilia to propel fluid and achieve motility. The beating of these organelles, and the corresponding ability to sense, respond to and modulate this beat is central to many processes in health and disease. While the mechanics of flagellum–fluid interaction has been the subject of extensive mathematical studies, these models have been restricted to being geometrically linear or weakly nonlinear, despite the high curvatures observed physiologically. We study the effect of geometrical nonlinearity, focusing on the spermatozoon flagellum. For a wide range of physiologically relevant parameters, the nonlinear model predicts that flagellar compression by the internal forces initiates an effective buckling behaviour, leading to a symmetry-breaking bifurcation that causes profound and complicated changes in the waveform and swimming trajectory, as well as the breakdown of the linear theory. The emergent waveform also induces curved swimming in an otherwise symmetric system, with the swimming trajectory being sensitive to head shape—no signalling or asymmetric forces are required. We conclude that nonlinear models are essential in understanding the flagellar waveform in migratory human sperm; these models will also be invaluable in understanding motile flagella and cilia in other systems
International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13
This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH), by the ADAMTS13 Assay Working Group, which comprises an international group of both clinical and laboratory experts. The document provides recommendations on best practice for the performance of ADAMTS13 assays in clinical laboratories. ADAMTS13 assays support the differential diagnosis of thrombotic microangiopathies and have utility in the management of thrombotic thrombocytopenic purpura (TTP). There are three types of assay: activity, antigen and autoantibody/inhibitor assays. Methods for activity assays differ in terms of sensitivity, specificity, precision and turnaround time. The most widely used assays involve VWF peptide substrates and either chromogenic ELISA or FRET techniques, although chemiluminescence assays and rapid screening tests have recently become available. Tests for autoantibodies and inhibitors allow confirmation of acquired, immune‐mediated TTP, while antigen assays may be useful in congenital TTP and as prognostic markers. In this document, we have attempted to describe ADAMTS13 assays and the conditions that affect them, as well as: blood collection, sample processing, quality control, standardization and clinical utility; recognizing that laboratories in different parts of the world have varying levels of sophistication. The recommendations are based on expert opinion, published literature and good clinical laboratory practice
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