773 research outputs found
Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma
Abstract
BACKGROUND:
This retrospective study aimed to determine how often a perimetric examination should be carried out in order to identify visual field (VF) changes in patients with relatively early manifestation glaucoma.
MATERIALS AND METHODS:
Patients included had a relatively recent manifestation of primary open-angle glaucoma. Patients with a minimum follow-up of 5 years and a minimum of seven VF tests were included. Statistical analysis was performed to verify the trend of variations in mean defect (MD) over time (PeriData). The results were subjected to a t-test for a comparative analysis of progression of VF changes over time. The annual rate of progression provided by PeriData considering all the VFs analyzed was compared with that obtained on half of the VF examinations during the same follow-up period. An analysis of the MD trend over time was also carried out in relationship to the number of VF tests done and by dividing the sample into a high-frequency group (more than eight VFs) and a low-frequency group (fewer than eight VFs) in the follow-up period.
RESULTS:
A total of 96 eyes of 96 patients were included, and overall 846 VFs were examined. The paired t-test performed comparing the MD index of all the VFs against half of them did not show statistical significance (P=0.537). The high-frequency group comprised 39 eyes (average VF 11.05±1.91, average time interval 0.76 years) while the low-frequency group comprised 57 eyes (average VF 6.95±0.6, average time interval 1.21 years). The analysis of the MD trend in the high-frequency patients showed significance (P=0.017); the low-frequency group did not show statistical significance (P=0.08).
CONCLUSION:
The number of VFs in a determined time interval was not significant. However, a greater frequency of tests provides a predictive evaluation of the rate of progression of early manifestation open-angle glaucoma
Analysis of the Spectral Energy Distributions of Fermi bright blazars
Blazars are a small fraction of all extragalactic sources but, unlike other
objects, they are strong emitters across the entire electromagnetic spectrum.
In this study we have conducted a detailed investigation of the broad-band
spectral properties of the gamma-ray selected blazars of the Fermi-LAT Bright
AGN Sample (LBAS). By combining the accurately estimated Fermi gamma-ray
spectra with Swift, radio, NIR-Optical and hard-X/gamma-ray data, collected
within three months of the LBAS data taking period, we were able to assemble
high-quality and quasi-simultaneous Spectral Energy Distributions (SED) for 48
LBAS blazars.Comment: 6 pages, 8 figures, "2009 Fermi Symposium", "eConf Proceedings
C091122
Functional biases in GRB's spectral parameter correlations
Gamma Ray Bursts (GRBs) show evidence of different spectral shapes, light
curves, duration, host galaxies and they explode within a wide redshift range.
However, the most of them seems to follow very tight correlations among some
observed quantities relating to their energetic. If true, these correlations
have significant implications on burst physics, giving constraints on
theoretical models. Moreover, several suggestions have been made to use these
correlations in order to calibrate GRBs as standard candles and to constrain
the cosmological parameters. We investigate the cosmological relation between
low energy index in GRBs prompt spectra and the redshift . We
present a statistical analysis of the relation between the total isotropic
energy and the peak energy (also known as Amati relation) in
GRBs spectra searching for possible functional biases. Possible implications on
the vs relation of the vs correlation are
evaluated. We used MonteCarlo simulations and the boostrap method to evaluate
how large are the effects of functional biases on the vs . We
show that high values of the linear correlation coefficent, up to about 0.8, in
the vs relation are obtained for random generated samples of
GRBs, confirming the relevance of functional biases. Astrophysical consequences
from vs relation are then to be revised after a more accurate
and possibly bias free analysis.Comment: 6 pages, 6 figures, conference poster session: "070228: The Next
Decade of Gamma-Ray Burst Afterglows", Amsterdam, March 2007, MNRAS submitte
Blazar surveys with WMAP and Swift
We present the preliminary results from two new surveys of blazars that have
direct implications on the GLAST detection of extragalactic sources from two
different perspectives: microwave selection and a combined deep X-ray/radio
selection. The first one is a 41 GHz flux-limited sample extracted from the
WMAP 3-yr catalog of microwave point sources. This is a statistically well
defined sample of about 200 blazars and radio galaxies, most of which are
expected to be detected by GLAST. The second one is a new deep survey of
Blazars selected among the radio sources that are spatially coincident with
serendipitous sources detected in deep X-ray images (0.3-10 keV) centered on
the Gamma Ray Bursts (GRB) discovered by the Swift satellite. This sample is
particularly interesting from a statistical viewpoint since a) it is unbiased
as GRBs explode at random positions in the sky, b) it is very deep in the X-ray
band (\fx \simgt \ergs) with a position accuracy of a few
arc-seconds, c) it will cover a fairly large (20-30 square deg.) area of sky,
d) it includes all blazars with radio flux (1.4 GHz) larger than 10 mJy, making
it approximately two orders of magnitude deeper than the WMAP sample and about
one order of magnitude deeper than the deepest existing complete samples of
radio selected blazars, and e) it can be used to estimate the amount of
unresolved GLAST high latitude gamma-ray background and its anisotropy
spectrum.Comment: 3 pages, 3 figures, to appear in Proc. of the 1st GLAST Symposium,
Feb 5-8, 2007, Stanford, AIP, Eds. S. Ritz, P. F. Michelson, and C. Meega
Swift and Fermi observations of X-ray flares: the case of Late Internal Shock
Simultaneous Swift and Fermi observations of gamma-ray bursts (GRBs) offer a
unique broadband view of their afterglow emission, spanning more than ten
decades in energy. We present the sample of X-ray flares observed by both Swift
and Fermi during the first three years of Fermi operations. While bright in the
X-ray band, X-ray flares are often undetected at lower (optical), and higher
(MeV to GeV) energies. We show that this disfavors synchrotron self-Compton
processes as origin of the observed X-ray emission. We compare the broadband
properties of X-ray flares with the standard late internal shock model, and
find that, in this scenario, X-ray flares can be produced by a late-time
relativistic (Gamma>50) outflow at radii R~10^13-10^14 cm. This conclusion
holds only if the variability timescale is significantly shorter than the
observed flare duration, and implies that X-ray flares can directly probe the
activity of the GRB central engine.Comment: 13 pages, 4 figures, accepted for publication in Ap
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