Divalent triazole‐linked carbohydrate mimetics: Synthesis by click chemistry and evaluation as selectin ligands

Starting from an enantiopure 3‐amino‐substituted pyran derivative, the synthesis of a series of divalent 1,2,3‐triazole‐linked carbohydrate mimetics is described. The preparation of the required 3‐azido‐substituted pyran proceeds smoothly by copper‐catalyzed diazo transfer. Using different conditions for the Huisgen‐Meldal‐Sharpless cycloaddition, this azide reacts with several diynes to furnish the desired divalent carbohydrate mimetics bearing rigid or flexible linker units. The in situ generation of the 3‐azidopyran in the presence of Cu/C as catalyst followed by the reaction with the alkyne allows a direct one‐pot transformation from the 3‐aminopyran to the desired click products. We also examined the Sakai‐Westermann method that transfers primary amines with the aid of α,α‐dichlorotosylhydrazones into 1,2,3‐triazoles. These copper‐free click conditions were applied for the first time to the preparation of a divalent compound. The O‐sulfation of the carbohydrate mimetics was achieved using the SO3‐DMF complex under careful 1H‐NMR control. Five polysulfated compounds could be obtained in pure form and these were tested by surface plasmon resonance spectroscopy as inhibitors of L‐selectin giving IC50 values between 45 nm and 50 µm

Technology production of carbon nanofibers and methane-hydrogen mixture in the reactor of catalytic decomposition natural gas

This paper presents a technology of production methane-hydrogen mixture for use as motor fuel. We investigated different the various modes and selected the most effective catalysts for this process. Established optimal condition for carry out this process

Mechanical properties of the cellular structures based on the isotruss unit cell^®

Summary. The present work aims to investigate the mechanical properties of the cellular structure based on the Isotruss unit cell by implementing the finite element method (FEM) introducing a representative elementary volume (REV). As an orthotropic cellular structure, the three principal Young’s modulus along the longitudinal and transversal directions are evaluated. The influence of the geometrical parameters on the elastic properties is studied in detail. Results reveal that Young’s modulus in two transverse directions are almost close, showing a 12% difference. Besides, the proposed unit cell presents the ability to tune the elasticity along with the main directions. It is seen that increasing the angle of helical pitch, increases the longitudinal Young’s modulus while decreases the transverse ones that suggest a considerable possibility for optimal designs. As an example, mimicking Young’s modulus of the human cortical bone as an orthotropic material is explored and it is seen that the presented cellular structure based on the Isotruss unit cell can successfully fit

Кадровый резерв в организации на примере государственной жилищной инспекции Новосибирской области

Объектом является кадровая политика в государственной жилищной инспекции Новосибирской области.Цель - оценить формирование кадрового резерва в государственной жилищной инспекции Новосибирской области на предмет эффективности и выбрать варианты его совершенствования.В результате исследования были разработаны рекомендации по совершенствованию формирования кадрового резерва.The object is the personnel policy in the state housing inspection of the Novosibirsk region. The goal is to assess the formation of the personnel reserve in the state housing inspection of the Novosibirsk region for efficiency and to choose options for its improvement. As a result of the research, recommendations were developed to improve the formation of the personnel reserve

Mechanical Properties of the Cellular Structures Based On the Isotruss Unit Cell

The present work aims to investigate the mechanical properties of the cellular structure based on the Isotruss unit cell by implementing the finite element method (FEM) introducing a representative elementary volume (REV). As an orthotropic cellular structure, the three principal Young's modulus along the longitudinal and transversal directions are evaluated. The influence of the geometrical parameters on the elastic properties is studied in detail. Results reveal that Young's modulus in two transverse directions are almost close, showing a 12% difference. Besides, the proposed unit cell presents the ability to tune the elasticity along with the main directions. It is seen that increasing the angle of helical pitch, increases the longitudinal Young's modulus while decreases the transverse ones that suggest a considerable possibility for optimal designs. As an example, mimicking Young's modulus of the human cortical bone as an orthotropic material is explored and it is seen that the presented cellular structure based on the Isotruss unit cell can successfully fit

Camera, handlens, and microscope optical system for imaging and coupled optical spectroscopy

An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument

Camera, handlens, and microscope optical system for imaging and coupled optical spectroscopy

An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument