A study on the left ventricular hypertrophy among the patients of chronic kidney disease stage third to five

Background: In Chronic kidney Disease (CKD) a significant risk factor for mortality is Cardiovascular disease (CVD) and the most prevalent cardiovascular risk factor is left ventricular hypertrophy (LVH). Anemia, hypertension and volume overload are risk factors for LVH in CKD. So, the present was aimed at comparing the risk factors between CKD with and without LVH.Methods: A cross sectional study carried out over a 2 year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh. A total of 120 patients are included in this study and divided in to CKD stage III to V based on estimated GFR. Based on 2D echocardiography data CKD cases are further divided in to CKD with LVH and CKD without LVH.Results: The Left ventricular mass index was significant higher in CKD with LVH (128.89±19.28) when compared with CKD without LVH (108.20±10.28). The left ventricular mass index was noted in more number in stage V of CKD. It is also observed that the left ventricular mass index was negatively correlated with haemoglobin and eGFR and was positively correlated with systolic blood pressure and serum NT-proBNP.Conclusions: Present study finding suggested that the incidence of LVH is higher in CKD patients. LVH was positively correlated with hypertension and NT-proBNP and negatively correlated with anemia and estimated GFR

Level of physical activity, determinants and barriers to motivate physical activities among south Indian diabetic patients: a prospective, questionnaire based study

Background: Several clinical trials have been reported that sedentary lifestyle modification including physical activity (PA) and weight loss significantly alters the sort-term as well as long-term incidence of diabetes. The present study explored the level of physical activity and its barriers among south Indian naïve patients who are attending the tertiary care teaching hospital.Methods: A prospective observational, questionnaire-based study. Patients with diabetes (both Type-1 and 2) who were attended diabetic clinic in the Department of General Medicine, Maharaja Institute of Medical Sciences (MIMS), Vijayanagaram, Andhra Pradesh, India was selected and recruited. Demographic data, clinical data were collected from the study participants. International Physical Activity questionnaire was used to determine each patient level of physical activity (PA). Physical activity is graded into low (3000 MET).Results: A total of 300 subjects were completed the entire study. Majority (62.7%) of the patients were suffering from Type-2 diabetes mellitus. Both male and female study subjects had low physical activity (70.5% and 74.1%) and moderate PA was seen in only one thirds of the patients. Patients with low physical activity had low glycaemic control compared to patients who were involved in moderate PA. Moderate PA patients had adequate glycaemic control (65.9 vs 34.1%, P <0.001). A total of 42.0% of subjects were suffering from one of the joint pains and friction joints, due to the following reason subjects were not involved in the PA.Conclusions: Low level of physical activity was observed in the study population, which is a risk factor for several micro-vascular complications over a period of time. It is very important to address the barriers of PA and vigorous counselling is needed which directs towards increasing PA

Status of vitamin D, lipid profile and carotid artery intima media thickness in patients with chronic kidney disease stage III to V

Background: Chronic Kidney Disease (CKD) is characterized by irreversible sclerosis and loss of nephrons. The renal mass progressively declines over a prolonged period, depending on the underlying etiology. In CKD the most common feature is hypovitaminosis D which alter the vascular smooth muscle cell proliferation and reprogram the osteoblastic changes, finally leading to increase arterial wall thickness.Methods: A cross sectional study carried out over a 2-year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh, India. 120 in which 60 are normal healthy individuals and 60 are CKD patients with stage 3 to 5. In all the participants serum creatinine, blood urea, serum triglycerides serum total cholesterol, HDL cholesterol estimated and serum 25 OH vitamin D are estimated.Results: The diagnostic criteria for CKD like blood urea, serum creatinine and eGFR were significantly higher in CKD when compared to control. In the present study, systolic and diastolic blood pressure was significantly increased in CKD compared with control. The Carotid Intima Media Thickness (CIMT) both left and right side were significant higher in CKD when compared with control. There is a significantly decreased levels of serum vitamin D in CKD (14.53 ng/mL±6.88) when compared with control (28.87 ng/mL±6.28).Conclusions: Present study finding suggested that there is a raised value of CIMT in CKD patients. High triglycerides, cholesterol and decreased HDL and declined vitamin D low hemoglobin, decreased eGFR, increased systolic blood pressure, raised CIMT value were found to be significantly increased in CKD patients

Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping

BACKGROUND: Trofile is the prospectively validated HIV-1 tropism assay. Its use is limited by high costs, long turn-around time, and inability to test patients with very low or undetectable viremia. We aimed at assessing the efficiency of population genotypic assays based on gp120 V3-loop sequencing for the determination of tropism in plasma viral RNA and in whole-blood viral DNA. Contemporary and follow-up plasma and whole-blood samples from patients undergoing tropism testing via the enhanced sensitivity Trofile (ESTA) were collected. Clinical and clonal geno2pheno[coreceptor] (G2P) models at 10% and at optimised 5.7% false positive rate cutoff were evaluated using viral DNA and RNA samples, compared against each other and ESTA, using Cohen's kappa, phylogenetic analysis, and area under the receiver operating characteristic (AUROC). RESULTS: Both clinical and clonal G2P (with different false positive rates) showed good performances in predicting the ESTA outcome (for V3 RNA-based clinical G2P at 10% false positive rate AUROC = 0.83, sensitivity = 90%, specificity = 75%). The rate of agreement between DNA- and RNA-based clinical G2P was fair (kappa = 0.74, p < 0.0001), and DNA-based clinical G2P accurately predicted the plasma ESTA (AUROC = 0.86). Significant differences in the viral populations were detected when comparing inter/intra patient diversity of viral DNA with RNA sequences. CONCLUSIONS: Plasma HIV RNA or whole-blood HIV DNA V3-loop sequencing interpreted with clinical G2P is cheap and can be a good surrogate for ESTA. Although there may be differences among viral RNA and DNA populations in the same host, DNA-based G2P may be used as an indication of viral tropism in patients with undetectable plasma viremia

STUDY OF DIURETIC ACTIVITY OF ETHONOLIC EXTRACT OF LEAVES OF CISSAMPELOS PAREIRA IN RATS

                                                       ABSTRACT Objective: To study the diuretic activity of ethanolic extract of leaves of Cissampelos pareira (EELCP) by Lipschitz method in albino rats .Methods:  Five groups of Albino rats were used to study the diuretic activity of EELCP by using metabolic cages. Group-I serves as normal control received vehicle (CMC 2% in normal saline), group II received Furosemide (10 mg/kg, p.o) in vehicle; other groups III, IV and V were treated with low (100 mg/kg), medium (200 mg/kg), and high (400 mg/kg) doses of EELCP in vehicle . Immediately after the extract treatment all the rats were hydrated with saline (15 ml/kg,p.o) and placed in the metabolic cages (3 per cage), specially designed to separate urine and faeces, kept at 21°C±0.5°C.The total volume of urine collected was measured at the end of 5th h. During this period, no food and water was made available to animals. Various parameters like total urine volume and concentration of Sodium, Potassium , Chloride ions in the urine were measured and estimated respectively.Results: When compared to vehicle treated control group the EELCP at different dose levels (100,200 and 400 mg/kg) has significantly increased the urine volume and also enhanced the elimination of Sodium, Potassium and Chloride ions in urine. Conclusion :Results showed that single dose administration of EELCP as 100, 200 and 400 mg/Kg and standard Furosemide (10 mg/kg b.wt) has significantly ( p&lt;0.001***)  increased the urine output along with an increase in concentration of Sodium, Potassium, and Chloride

Tribological properties of impregnated gloves for high temperature applications

Intervention during an unintentional fire puts a tremendous weight on the shoulders of the heroic first responder—and while his/her safety equipment is often overlooked supposedly for practicality, fire-resistant gloves with better insulation and increased dexterity would help dramatically. We are developing gloves using two kinds of glove materials—each impregnated with a ternary material containing a flexible matrix and two fillers, one with very high thermal conductivity and the other surviving high temperatures. Extant first fire responder gloves contain Kevlar and/or leather, while our materials allow gloves ‘survival’ at temperatures significantly higher than that of the Kevlar or organic material thermal decomposition. Essential here also are low water absorption and high scratch resistance of the gloves

Durability of portland concrete containing polymeric fillers and fly ash

Portland concrete suffers in service brittle failure, extensive crack propagation, and wear rates increasing with time. In spite of all the effort expended, these problems persisted when we had started our project. We used several polymeric fillers and fly ash. Higher compressive moduli than the starting concrete are seen for some compositions, the highest for 5 % of one of the polymers + 5 % fly ash. The same composition has the lowest Taber abrasive wear loss. All composites show lower wear loss values than Portland concrete. After 25 days of acidic degradation in 4.0 molar aq. HCl, the starting Portland concrete suffers stronger degradation that our composites. Polymer swelling mitigates acidic degradation. Repetitive freeze-thaw cycles between 15oF and 85oF show disappearance of the deep voids present before the first cycle in our composites but not in the Portland cement. While the use of fly ash mitigates contamination of the environment, it is the combination of fly ash with polymers which provides significantly improved properties – tribological, chemical and mechanical ones – of the Portland concrete. © 2020, Kauno Technologijos Universitetas. All rights reserved