58 research outputs found
Перспективы развития фундаментальных наук. Т. 5 : Экономика и управление
Сборник содержит труды участников XV Международной конференции студентов, аспирантов и молодых учёных «Перспективы развития фундаментальных наук», представленные на секции «Экономика и управление». Для студентов, аспирантов, молодых ученых и преподавателей, специализирующихся в области цифровой экономики, институциональной и отраслевой экономики, инновационной политики и предпринимательства, налоговой политики и регулирования, финансов, денежного обращения и кредита, учёта, анализа и аудита, статистики, менеджмента, экономики труда, математических методов и информационных технологий в экономике, менеджменте и бизнесе, развития системы государственного и муниципального управления, междисциплинарного исследования в экономике, а также международных экономических отношений
Vitamin D nutritional status and vitamin D regulated antimicrobial peptides in serum and pleural fluid of patients with infectious and noninfectious pleural effusions
Background: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and ?-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Methods: Serum and pleural fluid samples from 152 patients with pleural effusion were collected, corresponding to 45 transudates and 107 exudates, 51 infectious effusions (14 complicated and 37 non-complicated), 44 congestive heart failure effusions and 38 malignant effusions. The levels of 25 OH-vitamin D, 1,25-(OH)2-vitamin D, Vitamin D Binding Protein (VDBP), LL-37 and ?-defensin 2, both in serum and pleural fluid were evaluated in this prospective study. Differences between groups were analysed using unpaired t tests or Mann?Whitney tests. Correlations between data sets were examined using Pearson correlation coefficient or Spearman rank correlation coefficient. Diagnostic accuracy was estimated using ROC curve analysis. Results: Low serum 25 OH vitamin D levels were found in all groups. Infectious effusions (IE) had higher serum and pleural fluid LL-37 levels compared to congestive heart failure or malignant effusions. Among IE, complicated had higher serum and pleural fluid LL-37 levels, and lower serum ?-defensin-2 levels. Positive correlations were found between serum 25 OH-vitamin D levels and serum or pleural 1,25-(OH)2-vitamin D levels, and between 1,25-(OH) 2-vitamin D and LL-37 serum. Diagnostic accuracy of the different molecules was moderate at best. Conclusions: Hypovitaminosis D is highly prevalent in pleural effusions. LL-37 is produced intrapleurally in IE. This production is higher in complicated IE. No evidence of pleural production of ?-defensin 2 was found in any of the groups. Diagnostic accuracy of the different molecules is at the best moderate for discriminating different types of effusions
Abrasion arthroplasty increases mesenchymal stem cell content of postoperative joint effusions
Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration
Versorung der distalen Radiusfraktur mit einer winkelstabilen karbon-verstärkten Polymer-Komposit Platte - Pilotstudie zur Durchführbarkeit
Platelet-derived extracellular vesicles promote osteoinduction of mesenchymal stromal cells
Die Expression der antimikrobiellen Peptide HBD-2 und -3 im Knochen wird über die Toll-like-Rezeptoren-2 und -4 reguliert
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