1,576 research outputs found
Meditate don't medicate: How medical imaging evidence supports the role of meditation in the treatment of depression
Tagless indoor positioning and object tracking using a wireless sensor network
This project seeks to implement a passive indoor positioning and tracking platform
using Wi-Fi signals. It is well known that RF wave can be blocked by an object which results in signal
attenuation [1 - 2]. The principle of this proposal is based on this phenomenon when the line-of-sight
(LOS) link is blocked by an object. Hence, when a grid of such LOS links is tresspassed, it can be detected
and tracked within the region
Tagless indoor positioning and object tracking using a wireless sensor network
This project seeks to implement a passive indoor positioning and tracking platform
using Wi-Fi signals. It is well known that RF wave can be blocked by an object which results in signal
attenuation [1 - 2]. The principle of this proposal is based on this phenomenon when the line-of-sight
(LOS) link is blocked by an object. Hence, when a grid of such LOS links is tresspassed, it can be detected
and tracked within the region
Rectal Carcinoma: Multi-Modality Approach in Curative Local Treatment of Early Rectal Carcinoma
Analisis Efektivitas Penerimaan Pajak Bumi dan Bangunan Perdesaan dan Perkotaan (PBB-PP) di Kecamatan Sario Kota Manado
Penelitian ini bertujuan untuk menganalisis efektivitas penerimaan pajak bumi dan bangunan perdesaan dan perkotaan. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan kuantitatif yang dimana data olahan mengambil sumber pendapatan Pajak Bumi dan Bangunan Perdesaan dan Perkotaan (PBB-PP) di Kecamatan Sario Kota Manado dalam kurun Tahun 2018-2020. Teknik pengumpulan data yang digunakan adalah wawancara secara langsung dengan dua informan sebagai Camaat Sario dan kepala bagian bidang PBB di Dinas Pendapatan Daerah Kota Manado dan melakukan observasi. Hasil penelitian menunjukan bahwa penerimaan pajak bumi dan bangunan perdesaan dan perkotaan di kecamatan sario mengalami penurunan dari tahun 2018-2020. Pada tahun 2018 sebesar 88,81% atau dikatakan cukup efektif, 2019 sebesar 85,72% atau dikatakan cukup efektif dan 2020 sebesar 82,89% atau dikatakan cukup efektif dikarenakan kurangnya kesadaran wajib pajak, perlu adanya pendataan ulang objek Pajak Bumi dan Bangunan Perdesaan dan Perkotaan, penetapan kembali target penerimaan Pajak Bumi dan Bangunan Perdesaan dan Perkotaan, sehingga pencapaian penerimaan pendapatan dan realisasi pajak bumi dan bangunan perdesaan dan perkotaan tahun 2018-2020 dikatakan cukup efektif
Penggunaan Pembobotan Model Black-litterman Dalam Menentukan Value at Risk Pada Portofolio Investasi
This paper discusses the use of the Black-Litterman weighting in determining the value at risk in the investment portfolio. Black-Litterman model obtained through sampling theory approach is used to determine the weight of each portfolio asset. Based on theweight of assets of the Black-Litterman obtained standard deviation Black-Litterman portfolio is used in the calculation of Value at Risk in the Black-Litterman portfolio
Process description and evaluation of Canadian Physical Activity Guidelines development
<p>Abstract</p> <p>Background</p> <p>This paper describes the process used to arrive at recommended physical activity guidelines for Canadian school-aged children and youth (5-17 years), adults (18-64 years) and older adults (≥65 years).</p> <p>Methods</p> <p>The Canadian Society for Exercise Physiology (CSEP) Physical Activity Measurement and Guidelines (PAMG) Steering Committee used the Appraisal of Guidelines for Research Evaluation (AGREE II) Instrument to inform the guideline development process. Fourteen background papers and five systematic reviews were completed. Systematic review authors appraised and synthesized the data, and proposed specific recommendations at an international consensus conference of invited experts and key stakeholders. Independently, an international panel of experts interpreted the evidence from the systematic reviews and developed recommendations following attendance at the Consensus Conference.</p> <p>Results</p> <p>Using the AGREE II instrument as a guide, specific <it>foci </it>for each of the guidelines were defined and systematic review methodology was used to synthesize the evidence base. The expert panel, CSEP PAMG Steering Committee and methodological consultants reviewed the systematic reviews and Consensus Statement. The expert panel achieved consensus on the level of evidence informing the physical activity guidelines and developed a separate document outlining key recommendations, interpretation of the evidence and justification of each recommendation.</p> <p>Conclusion</p> <p>The CSEP and Public Health Agency of Canada followed a rigorous process to examine the evidence informing potential revisions to existing physical activity guidelines for Canadians. It is believed that this is the first physical activity guideline development process in the world to be guided and assessed by AGREE II and AMSTAR instruments.</p
Network analysis of pseudogene-gene relationships: from pseudogene evolution to their functional potentials
Pseudogenes are fossil relatives of genes. Pseudogenes have long been thought of as "junk DNAs", since they do not code proteins in normal tissues. Although most of the human pseudogenes do not have noticeable functions, ∼20% of them exhibit transcriptional activity. There has been evidence showing that some pseudogenes adopted functions as lncRNAs and work as regulators of gene expression. Furthermore, pseudogenes can even be "reactivated" in some conditions, such as cancer initiation. Some pseudogenes are transcribed in specific cancer types, and some are even translated into proteins as observed in several cancer cell lines. All the above have shown that pseudogenes could have functional roles or potentials in the genome. Evaluating the relationships between pseudogenes and their gene counterparts could help us reveal the evolutionary path of pseudogenes and associate pseudogenes with functional potentials. It also provides an insight into the regulatory networks involving pseudogenes with transcriptional and even translational activities.In this study, we develop a novel approach integrating graph analysis, sequence alignment and functional analysis to evaluate pseudogene-gene relationships, and apply it to human gene homologs and pseudogenes. We generated a comprehensive set of 445 pseudogene-gene (PGG) families from the original 3,281 gene families (13.56%). Of these 438 (98.4% PGG, 13.3% total) were non-trivial (containing more than one pseudogene). Each PGG family contains multiple genes and pseudogenes with high sequence similarity. For each family, we generate a sequence alignment network and phylogenetic trees recapitulating the evolutionary paths. We find evidence supporting the evolution history of olfactory family (both genes and pseudogenes) in human, which also supports the validity of our analysis method. Next, we evaluate these networks in respect to the gene ontology from which we identify functions enriched in these pseudogene-gene families and infer functional impact of pseudogenes involved in the networks. This demonstrates the application of our PGG network database in the study of pseudogene function in disease context
Identifying risk factors for healthcare-associated infections from electronic medical record home address data
<p>Abstract</p> <p>Background</p> <p>Residential address is a common element in patient electronic medical records. Guidelines from the U.S. Centers for Disease Control and Prevention specify that residence in a nursing home, skilled nursing facility, or hospice within a year prior to a positive culture date is among the criteria for differentiating healthcare-acquired from community-acquired methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) infections. Residential addresses may be useful for identifying patients residing in healthcare-associated settings, but methods for categorizing residence type based on electronic medical records have not been widely documented. The aim of this study was to develop a process to assist in differentiating healthcare-associated from community-associated MRSA infections by analyzing patient addresses to determine if residence reported at the time of positive culture was associated with a healthcare facility or other institutional location.</p> <p>Results</p> <p>We identified 1,232 of the patients (8.24% of the sample) with positive cultures as probable cases of healthcare-associated MRSA based on residential addresses contained in electronic medical records. Combining manual review with linking to institutional address databases improved geocoding rates from 11,870 records (79.37%) to 12,549 records (83.91%). Standardization of patient home address through geocoding increased the number of matches to institutional facilities from 545 (3.64%) to 1,379 (9.22%).</p> <p>Conclusions</p> <p>Linking patient home address data from electronic medical records to institutional residential databases provides useful information for epidemiologic researchers, infection control practitioners, and clinicians. This information, coupled with other clinical and laboratory data, can be used to inform differentiation of healthcare-acquired from community-acquired infections. The process presented should be extensible with little or no added data costs.</p
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