The impact of Mediterranean oscillations on periodicity and trend of temperature in the valley of the Nisava river - a fourier and wavelet approach

Periodicity of temperature on three stations in the Nisava River valley in period 1949-2014, has been analyzed by means of Fourier and wavelet transforms. Combined periodogram based on fast Fourier transform shows considerable similarity among individual series and identffies significant periods on 2.2, 2.7, 3.3, 5, 6-7, and 8.2 years in all datasets. Wavelet coherence analysis connects strongest 6-7 years spectral component to Mediterranean oscillation, starting in 1980s. Combined periodogram of Mediterranean oscillation index reveals 6-7 years spectral component as a dominant mode in period 1949-2014. Wavelet power spectra and partial combined periodograms show absence of 6-7 years component before 1975, after which this component becomes dominant in the spectrum. Consistency between alternation in temperature trend in the Nisava River valley and change in periodicity of Mediterranean oscillation was found

Changes in Soil Erosion Intensity Caused by Land Use and Demographic Changes in the Jablanica River Basin, Serbia

The aim of this research is to determine the change in the spatial distribution of erosion intensity in the territory of the Jablanica River Basin in the period 1971-2016 caused by land use and demographic changes. The Erosion Potential Method (EPM) was used to quantify changes in erosion intensity and to estimate the total annual sediment yield. The research results show that the value of the erosion coefficient decreased from 0.432 in 1971 to 0.360 in 2016. Specific annual gross erosion in the Jablanica River Basin was 654.41 m(3)/km(2)/year in 1971, while in 2016 it was 472.03 m(3)/km(2)/year. The analysis of proportional changes was used to determine demographic changes and land use patterns in the basin area. In terms of the scale and intensity of the erosion process, three types and one sub-type of population dynamics of settlements and land use changes were distinguished, respectively: progressive, stagnant, regressive and dominant regressive. It was concluded that the results show the significance of demographic and land use changes in the control of the intensity of erosion. The Soil Erosion Map may be useful to planners and land use managers to take appropriate decisions for soil conservation in the basin

Statistical analysis of water quality parameters in the basin of the Nisava River (Serbia) in the period 2009-2018

This paper analyzes water quality from four hydrological stations in the Nisava river basin from 2009-2018 based on the following parameters: pH, conductivity, O-2 saturation, BOD5, suspended solids, total oxidized nitrogen, phosphates, turbidity and coliform bacteria. Authors have applied WQI (water quality index) as the most reliable indicator of the watercourses pollution for setting of surface water flow quality. Statistical analysis of variance (ANOVA) using t-test inferential statistical analysis and post-hoc Tukey test were applied to evaluate statistically significant differences between specific data groups. The results show that bad water quality was registered on all the profiles on an annual basis (WQI = 65-71). The river water pH decreases downstream, while values of BOD5, suspended solids, turbidity, TON, phosphates and coliform bacteria gradually increase. The waters of the Nisava at the station Nis belong to the third class of waters and they are mostly loaded with organic matter originating from waste sewage and industrial waters of both urban and rural areas

Statistical analysis of temperature regime change on the example of Sokobanja basin in eastern Serbia

The changes and oscillations in air temperature during the second half of the 20th and in the early 21st century, have become one of the major concerns of almost all scientific disciplines. Such changes are noticeable both at the local and global level. The objective of this paper is to point out that the changes of this climate element can also be detected at the local level. The research underlying this paper is, in terms of territory, limited to the Sokobanja basin in Eastern Serbia. The analysis relies on the data on air temperature for the period 1946-2012 taken from the Meteorological weather station located in Sokobanja. The obtained data were processed in line with the recommendations of the World Meteorological Organization. The evidenced statistically significant changes in air temperature were examined using the following statistical tests: Pettit test, Standard Normal Homogeneity test, Buishand range test, and von Neumann test

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that are responsible for protein synthesis. A wealth of research over the past 20 years has clearly indicated that both quantitative and qualitative alterations in ribosome biogenesis can drive the malignant phenotype via dysregulation of protein synthesis. However, numerous recent proteomic, genomic, and functional studies have implicated the nucleolus in the regulation of processes that are unrelated to ribosome biogenesis, including DNA-damage response, maintenance of genome stability and its spatial organization, epigenetic regulation, cell-cycle control, stress responses, senescence, global gene expression, as well as assembly or maturation of various ribonucleoprotein particles. In this review, the focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin. We will also present the most recent insights into how malfunction of these cellular processes may be a central driving force of human malignancies, and propose a promising new therapeutic approach for the treatment of cancer

Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress

Purpose High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. Methods In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NF kappa B, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha). Results High-fructose diet led to glucose intolerance, activation of NF kappa B and JNK pathways and increased intrahepatic IL-1 beta, TNF alpha and inhibitory phosphorylation of insulin receptor substrate 1 on Ser(307). It also decreased phospho-AMPK/AMPK ratio and increased SIRT1 expression. Stress alone increased plasma and hepatic corticosterone but did not influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins. After the combined treatment, hepatic corticosterone was increased, glucose tolerance remained preserved, while hepatic inflammation was partially prevented despite decreased AMPK activity. Conclusion High-fructose diet resulted in glucose intolerance, hepatic inflammation, decreased AMPK activity and reduced insulin sensitivity. Chronic stress alone did not exert such effects, but when applied together with high-fructose diet it could partially prevent fructose-induced inflammation, presumably due to increased hepatic glucocorticoids

Observed climate changes in the Toplica river valley : Trend analysis of temperature, precipitation and river discharge

Changes in air temperature, precipitation, and the Toplica river discharge were investigated. Annual and seasonal climatic data were collected at weather stations Kursumlija and Prokuplje, and discharge data on hydrological gauges Pepeljevac and Doljevac. The data covered a period of 62 years (1957–2018). Mann-Kendall and Pettitt’s tests have been applied for the periods 1957–2018, 1957–1987, 1988–2018, and 1975–1994, which we find as very important period when atmospheric circulation was altered. Mean annual temperature and precipitation were greater in the second half-period, while the discharge was smaller, even all the signals had growth trend. Mean seasonal temperature increased for all seasons, as well as precipitation, except for summer (JJA). The discharge is lower in the second half-period for almost all seasons, with signs of recovery for all seasons except summer

Abnormal uterine bleeding and severe anemia cause the life-threatening condition

The World Health Organisation (WHO) defines anemia as a global public health problem. It is a medical condition in which the number of red blood cells or the hemoglobin concentration within them is below the physiological range. We present a case of a 40-year-old woman with Abnormal Uterine Bleeding (AUB) accompanied by malaise, weakness, and tachycardia. The patient reported heavy menstrual bleeding for the past 14 days. Speculum examination revealed that the bleeding was from the uterus. There were no pathological findings during a gynecological and transvaginal ultrasound examination. A complete blood count performed at the time of her arrival showed a low hemoglobin level of 24 g/L, a low hematocrit level of 7,4%, a mean corpuscular volume of 98,7 fL and a number of red blood cells 0,75 x 1012/L. Due to the severity of the anemia, she was given 6 units of red blood cell transfusion, 2 fresh frozen plasmas and tranexamic acid accompanied with calcium carbonate. The curettage was performed. The pathohistological finding was endometrium in proliferation. Afterward, the hemoglobin level increased to 90 g/L. Their past medical history revealed that she abused alcohol. On an abdominal CT scan, Alcohol-Related Liver Disease (ARLD) was confirmed. We should keep in mind that coagulopathy could be the underlying cause of abnormal uterine bleeding and that anemia must be analyzed for successful treatment. A multidisciplinary approach to anemia caused by AUB is required in cases of severe anemia