Questioning a 3.5 keV dark matter emission line

Context. Recent findings of line emission at 3.5 keV in both individual and stacked X-ray spectra of galaxy clusters have been speculated to have dark matter origin. Aims. If the origin is indeed dark matter, the emission line is expected to be detectable from the Milky Way dark matter halo. Methods. We perform a line search in public Chandra X-ray observations of the region near Sgr A*. We derive upper limits on the line emission flux for the 2.0-9.0 keV energy interval and discuss their potential physical interpretations including various scenarios of decaying and annihilating dark matter. Results. While find no clear evidence for its presence, the upper flux limits are not inconsistent with the recent detections for conservative mass profiles of the Milky Way. Conclusions. The results depends mildly on the spectral modelling and strongly on the choice of dark matter profile.Comment: 10 pages, 7 figures, matches version accepted by A&

Deep Reinforcement Learning for Long Term Hydropower Production Scheduling

We explore the use of deep reinforcement learning to provide strategies for long term scheduling of hydropower production. We consider a use-case where the aim is to optimise the yearly revenue given week-by-week inflows to the reservoir and electricity prices. The challenge is to decide between immediate water release at the spot price of electricity and storing the water for later power production at an unknown price, given constraints on the system. We successfully train a soft actor-critic algorithm on a simplified scenario with historical data from the Nordic power market. The presented model is not ready to substitute traditional optimisation tools but demonstrates the complementary potential of reinforcement learning in the data-rich field of hydropower scheduling.Comment: 2020 International Conference on Smart Energy Systems and Technologies (SEST

Searching for decaying axion-like dark matter from clusters of galaxies

We consider the possibility of constraining the lifetime of radiatively decaying dark matter particles in clusters of galaxies inspired from generic axions of the Kaluza-Klein type. Such axions have been invoked as a possible explanation for the coronal X-ray emission from the Sun. These axions, or similar particles, can be produced inside stars and some of them remain confined by the deep gravitational potential of clusters of galaxies. Specifically, we consider regions within merging galaxy clusters (Abell 520 and the "Bullet Cluster"), where gravitational lensing observations have identified massive, but baryon poor, structures. From an analysis of X-ray observations of these mass concentrations, and the expected photon spectrum of decaying solar KK-axions, we derive lower limits to the lifetime of such axions of tau approx. 10^23 sec. However, if KK-axions constitute less than a few percent of the dark matter mass, this lifetime constraint is similar to that derived from solar KK-axions.Comment: Submitted to PRL, 4 pages, 3 figure

Probing the nature of dark matter with Cosmic X-rays: Constraints from "Dark blobs" and grating spectra of galaxy clusters

Gravitational lensing observations of galaxy clusters have identified dark matter ``blobs'' with remarkably low baryonic content. We use such a system to probe the particle nature of dark matter with X-ray observations. We also study high resolution X-ray grating spectra of a cluster of galaxies. From these grating spectra we improve the conservative constraints on a particular dark matter candidate, the sterile neutrino, by more than one order of magnitude. Based on these conservative constraints obtained from Cosmic X-ray observations alone, the low mass (m_s < 10keV) and low mixing angle (sin^2(2\theta) 10^{-6}) sterile neutrino is still a viable dark matter candidate.Comment: 4 pages, 4 figure

Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring

Animal studies suggest a role of vitamin D in fetal lung development although not studied in preterm animals. We tested the hypothesis that vitamin D depletion aggravates respiratory insufficiency in preterm rat offspring. Furthermore, the effects of vitamin D depletion on growth and lung surfactant were investigated. Female Sprague-Dawley rats were randomly assigned low vitamin D (VDL) or control diet before mating and followed with serum 25-hydroxyvitamin D (s-25(OH)D) determinations. After cesarean section at gestational day 19 (E19) or day 22 (E22), placental weight, birth weight, crown-rump-length (CRL), oxygenation (SaO2) at 30 min and survival time were recorded. The pup lungs were analyzed for phospholipid levels, surfactant protein A-D mRNA and the expression of the vitamin D receptor (VDR). S-25(OH)D was significantly lower in the VDL group at cesarean section (12 vs. 30nmol/L, p<0.0001). Compared to the controls, E19 VDL pups had lower birth weight (2.13 vs. 2.29g, p<0.001), lung weight (0.09 vs. 0.10g, p = 0.002), SaO2 (54% vs. 69%, p = 0.002) as well as reduced survival time (0.50 vs. 1.25h, p<0.0001). At E22, the VDL-induced pulmonary differences were leveled out, but VDL pups had lower CRL (4.0 vs. 4.5cm, p<0.0001). The phospholipid levels and the surfactant protein mRNA expression did not differ between the dietary groups. In conclusion, Vitamin D depletion led to lower oxygenation and reduced survival time in the preterm offspring, associated with reduced lung weight and birth weight. Further studies of vitamin D depletion in respiratory insufficiency in preterm neonates are warranted

Occupational Exposure and Environmental Release : The Case Study of Pouring TiO2 and Filler Materials for Paint Production

Pulmonary exposure to micro- and nanoscaled particles has been widely linked to adverse health effects and high concentrations of respirable particles are expected to occur within and around many industrial settings. In this study, a field-measurement campaign was performed at an industrial manufacturer, during the production of paints. Spatial and personal measurements were conducted and results were used to estimate the mass flows in the facility and the airborne particle release to the outdoor environment. Airborne particle number concentration (1 x 10(3)-1.0 x 10(4) cm(-3)), respirable mass (0.06-0.6 mg m(-3)), and PM10 (0.3-6.5 mg m(-3)) were measured during pouring activities. In overall; emissions from pouring activities were found to be dominated by coarser particles >300 nm. Even though the raw materials were not identified as nanomaterials by the manufacturers, handling of TiO2 and clays resulted in release of nanometric particles to both workplace air and outdoor environment, which was confirmed by TEM analysis of indoor and stack emission samples. During the measurement period, none of the existing exposure limits in force were exceeded. Particle release to the outdoor environment varied from 6 to 20 g ton(-1) at concentrations between 0.6 and 9.7 mg m(-3) of total suspended dust depending on the powder. The estimated release of TiO2 to outdoors was 0.9 kg per year. Particle release to the environment is not expected to cause any major impact due to atmospheric dilutionPeer reviewe

Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis

Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Here we study associations between anti-drug antibody (ADA) occurrence and demographic and clinical factors. Retrospective data from routine ADA test laboratories in Sweden, Denmark, Austria and Germany (Dusseldorf group) and from one research study in Germany (Munich group) were gathered to build a collaborative multi-cohort dataset within the framework of the ABIRISK project. A subset of 5638 interferon-beta (IFN beta)-treated and 3440 natalizumab-treated patients having data on at least the first two years of treatment were eligible for interval-censored time-to-event analysis. In multivariate Cox regression, IFN beta-1a subcutaneous and IFN beta-1b subcutaneous treated patients were at higher risk of ADA occurrence compared to IFN beta-1a intramuscular-treated patients (pooled HR = 6.4, 95% CI 4.9-8.4 and pooled HR = 8.7, 95% CI 6.6-11.4 respectively). Patients older than 50 years at start of IFN beta therapy developed ADA more frequently than adult patients younger than 30 (pooled HR = 1.8, 95% CI 1.4-2.3). Men developed ADA more frequently than women (pooled HR = 1.3, 95% CI 1.1-1.6). Interestingly we observed that in Sweden and Germany, patients who started IFN beta in April were at higher risk of developing ADA (HR = 1.6, 95% CI 1.1-2.4 and HR = 2.4, 95% CI 1.5-3.9 respectively). This result is not confirmed in the other cohorts and warrants further investigations. Concerning natalizumab, patients older than 45 years had a higher ADA rate (pooled HR = 1.4, 95% CI 1.0-1.8) and women developed ADA more frequently than men (pooled HR = 1.4, 95% CI 1.0-2.0). We confirmed previously reported differences in immunogenicity of the different types of IFN beta. Differences in ADA occurrence by sex and age are reported here for the first time. These findings should be further investigated taking into account other exposures and biomarkers