CA 15-3 prognostic biomarker in SARS-CoV-2 pneumonia.

The severity of lung involvement is the main prognostic factor in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Carbohydrate antigen 15-3 (CA 15-3), a marker of lung damage and fibrosis, could help predict the prognosis of SARS-CoV-2 pneumonia. This was a retrospective and observational study. CA 15-3 was analyzed in the blood samples of patients consecutively admitted for SARS-CoV-2 pneumonia and whose blood samples were available in the biobank. Other prognostic markers were also measured (interleukin 6 [IL6], C-reactive protein [CRP], D-dimer, troponin T, and NT-ProBNP). The occurrence of in-hospital complications was registered, including death, the need for medical intensive care, and oxygen therapy at discharge. In this study, 539 patients were recruited (54.9% men, mean age: 59.6 ± 16.4 years). At admission, the mean concentrations of CA 15-3 was 20.5 ± 15.8 U/mL, and the concentration was correlated with male sex, older age, and other severity markers of coronavirus disease of 2019 (COVID-19) (IL6, CRP, D-dimer, troponine T, and NT-ProBNP). CA 15-3 levels were higher in patients who died (n = 56, 10.4%) (35.33 ± 30.45 vs. 18.8 ± 12.11, p < 0.001), who required intensive medical support (n = 78, 14.4%; 31.17 ± 27.83 vs. 18.68 ± 11.83; p < 0.001), and who were discharged with supplemental oxygen (n = 64, 13.3%; 22.65 ± 14.41 vs. 18.2 ± 11.7; p = 0.011). Elevated CA 15-3 levels (above 34.5 U/mL) were a strong predictor of a complicated in-hospital course, in terms of a higher risk of death (adjusted odds ratio [OR] 3.74, 95% confidence interval [CI]: 1.22-11.9, p = 0.022) and need for intensive care (adjusted OR 4.56, 95% CI: 1.37-15.8) after adjusting for all other risk factors. The degree of lung damage and fibrosis evaluated in terms of CA 15-3 concentrations may allow early identification of the increased risk of complications in patients with SARS-CoV-2 pneumonia.S

Pervivencias paganas en la Hispania Tardoantigua (ss. IV-VII): Una aproximación desde la religiosidad popular

The aim of this work will be to approach sunivals of pagan manifestations in Late Antique Hispania (c. IV-VII) in the context of the appearance and establishment of the Christianity, the dominant religious system that cohabitatcd with different forms of paganism during this period. Idolism. sacrifices, offerings, festivals and entertainments arc going to be analyzed more specifically by literary means in order to explain and consider the reasons of their survival. In order to do so. an approach from popular religiosity will be adopted.El objetivo de este trabajo consiste en abordar las pervivencias paganas en Hispania durante la Antigüedad Tardía (ss. IV-VII). Dado que el surgimiento y establecimiento del cristianismo como sistema religioso dominante tuvo que coexistir con diversas manifestaciones paganas durante este periodo dc tiempo. De forma más especifica se analizaran las fuentes literarias referentes a la idolatría, sacrificios, festividades y espectáculos con el fin de reflexionar sobre los motivos que pueden explicar su pervivencia. realizando para ello una aproximación desde la religiosidad popular y la antropología

El magistrado don Fernando José de Velasco: Gestiones y cuidado de su biblioteca durante su estancia en la chancillería de granada (1766-1770)

During the eighteen century took place a growth of the private libraries, among standed out the libraries formed by the administration’s members. This was de case of the magistrate Fernando José de Velasco, who collected more than 10.000 volumes. Such number of books produced huge difficulties to Fernando José when, working at the court, he was designated in 1766 president of the “Real Chancillería” of Granada. This work is focused on the analysis of four letters about the managements that the magistrate had to do in order to protect his library while he was in Granada.En el siglo XVIII se produjo un auge en la creación de las bibliotecas privadas, entre las que destacaron las formadas por los miembros de la alta administración. Este fue el caso del magistrado don Fernando José de Velasco, que reunió una colección de más de 10.000 volúmenes. Tal cantidad de libros generó grandes dificultades a don Fernando José cuando, sirviendo en la corte, fue nombrado en 1766 presidente de la Real Chancillería de Granada. En este trabajo estudio cuatro cartas sobre las gestiones que realizó el magistrado para que su biblioteca permaneciera segura en Madrid durante el tiempo en que servía en Granada

ROBRES, Fernando Andrés, HERNÁNDEZ BENÍTEZ, Mauro y MARTÍNEZ BERMEJO, Saúl (eds.), Mirando desde el puente. Estudios en homenaje al profesor James S. Amelang, Madrid, Ediciones de la Universidad Autónoma de Madrid, 2019, 494 pp. ISBN: 978-84-8344

James Amelang es un autor de referencia para el estudio de la Edad Moderna. Entre sus líneas de investigación sobresalen la historia urbana, la historia social, la historia cultural, la autobiografía y la cultura popular. De manera más específica ha profundizado en cuestiones como las autobiografías populares y femeninas o la historia urbana de Barcelona. Ha destacado asimismo por ampliar  el concepto de autobiografía, al considerar como tal cualquier escrito que refleje una experiencia personal

Diagnostic yield of chest and thumb ECG after cryptogenic stroke, Transient ECG Assessment in Stroke Evaluation (TEASE): an observational trial

Objective In stroke survivors, atrial fibrillation (AF) is typically evaluated solely by short-term ECG monitoring in the stroke unit. Prolonged continuous ECG monitoring or insertable cardiac monitors require substantial resources. Chest and thumb ECG could provide an alternative means of AF detection, which in turn could allow prompt anticoagulation to prevent recurrent stroke. The objective of this study was to assess the yield of newly diagnosed AF during 28 days of chest and thumb ECG monitoring two times per day in cryptogenic stroke.Methods This study, Transient ECG Assessment in Stroke Evaluation, included patients who had a stroke from Region Gävleborg, Sweden, between 2017 and 2019. Patients with a recent ischaemic stroke without documented AF (or other reasons for anticoagulation) before or during ECG evaluation in the stroke unit were evaluated using the Coala Heart Monitor connected to a smartphone application for remote monitoring.Results The prespecified number of 100 patients (mean age 67.6±10.8 years; 60% men) was analysed. In nine patients (9%, number needed to screen 11) AF but no other significant atrial arrhythmias (&gt;30 s) was diagnosed. The mean CHA2DS2-VASc score was similar among patients with AF and no AF (4.9±1.1 vs 4.3±1.3; p=0.224) and patients with AF were older (74.3±9.0 vs 66.9±10.8; p=0.049). Patients performed on average 90.1%±15.0% of scheduled transmissions.Conclusion In evaluation of cryptogenic stroke, 9% of patients had AF detected using chest and thumb ECG two times per day during 1 month. In many stroke survivors, this is a feasible approach and they will be potentially protected from recurrent stroke by anticoagulation treatment.Trial registration number NCT03301662

Prevalence and genotype distribution of cervical human papilomavirus infection in the pre-vaccination era: a population-based study in the Canary Islands

Objective National Spanish studies show that prevalence of cervical human papillomavirus (HPV) infection in the female population is increasingly frequent, with an overall estimate of 14% in women aged 18–65 years. The objective of this study is to know the prevalence and distribution of HPV types in the female population of the Canary Islands prior to the introduction of HPV vaccines and to investigate the associated clinical and sociodemographic factors.Methods Based on the Primary Health Care database, a sample of adult women (aged 18–65 years) of Gran Canaria (GC) and Tenerife (TF) stratified into nine age groups was carried out between 2002 and 2007. Women were contacted by postal letter and telephone call and were visited in their primary care centre. A clinical-epidemiological survey was completed and cervical samples were taken for cytological study and HPV detection. HPV prevalence and its 95% CI were estimated, and multivariate analyses were performed using logistic regression to identify factors associated with the infection.Results 6010 women participated in the study, 3847 from GC and 2163 from TF. The overall prevalence of HPV infection was 13.6% (CI 12.8%–14.5%) and 11.1% (CI 10.3%–11.9%) for high-risk types. The most frequent HPV type was 16 followed by types 51, 53, 31, 42 and 59. HPV types included in the nonavalent vaccine were detected in 54.1% of infected women. Factors associated with an increased risk of infection were: young ages (18–29 years), the number of sexual partners throughout life, not being married, being a smoker, and having had previous cervical lesions or genital warts.Conclusions It is confirmed that prevalence of HPV infection in the female population of the Canary Islands is high, but similar to that of Spain, HPV 16 being the most frequent genotype. The determinants of infection are consistent with those of other populations