10 research outputs found
Predicting Housekeeping Genes Based on Fourier Analysis
Housekeeping genes (HKGs) generally have fundamental functions in basic biochemical processes in organisms, and usually have relatively steady expression levels across various tissues. They play an important role in the normalization of microarray technology. Using Fourier analysis we transformed gene expression time-series from a Hela cell cycle gene expression dataset into Fourier spectra, and designed an effective computational method for discriminating between HKGs and non-HKGs using the support vector machine (SVM) supervised learning algorithm which can extract significant features of the spectra, providing a basis for identifying specific gene expression patterns. Using our method we identified 510 human HKGs, and then validated them by comparison with two independent sets of tissue expression profiles. Results showed that our predicted HKG set is more reliable than three previously identified sets of HKGs
Association Study With 33 Single-Nucleotide Polymorphisms in 11 Candidate Genes for Hypertension in Chinese
Mass-Dependent and -Independent Fractionation of Mercury Isotope during Gas-Phase Oxidation of Elemental Mercury Vapor by Atomic Cl and Br
This study presents
the first measurement of Hg stable isotope
fractionation during gas-phase oxidation of Hg<sup>0</sup> vapor by
halogen atoms (Cl<sup>•</sup>, Br<sup>•</sup>) in the
laboratory at 750 ± 1 Torr and 298 ± 3 K. Using a relative
rate technique, the rate coefficients for Hg<sup>0</sup>+Cl<sup>•</sup> and Hg<sup>0</sup>+Br<sup>•</sup> reactions are determined
to be (1.8 ± 0.5) × 10<sup>–11</sup> and (1.6 ±
0.8) × 10<sup>–12</sup> cm<sup>3</sup> molecule<sup>–1</sup> s<sup>–1</sup>, respectively. Results show that heavier isotopes
are preferentially enriched in the remaining Hg<sup>0</sup> during
Cl<sup>•</sup> initiated oxidation, whereas being enriched
in the product during oxidation by Br<sup>•</sup>. The fractionation
factors for <sup>202</sup>Hg/<sup>198</sup>Hg during the Cl<sup>•</sup> and Br<sup>•</sup> initiated oxidations are α<sup>202/198</sup> = 0.99941 ± 0.00006 (2σ) and 1.00074 ± 0.00014 (2σ),
respectively. A Δ<sup>199</sup>Hg/Δ<sup>201</sup>Hg ratio
of 1.64 ± 0.30 (2σ) during oxidation of Hg<sup>0</sup> by
Br atoms suggests that Hg-MIF is introduced by the nuclear volume
effect (NVE). In contrast, the Hg<sup>0</sup> + Cl<sup>•</sup> reaction produces a Δ<sup>199</sup>Hg/Δ<sup>201</sup>Hg-slope of 1.89 ± 0.18 (2σ), which in addition to a high
degree of odd-mass-number isotope MIF suggests impacts from MIF effects
other than NVE. This reaction also exhibits significant MIF of <sup>200</sup>Hg (Δ<sup>200</sup>Hg, up to −0.17‰
in the reactant) and is the first physicochemical process identified
to trigger <sup>200</sup>Hg anomalies that are frequently detected
in atmospheric samples
Misdiagnosis of primary pleomorphic rhabdomyosarcoma of the right thigh in a young adult: A case report
An integrative approach to modeling land-use changes: multiple facets of agriculture in the Upper Yangtze basin
A 35-GHz polarimetrie Doppler radar and its application for observing clouds associated with Typhoon Nuri
A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases with coronary artery disease and 5,019 controls, followed by de novo replication studies in 15,460 cases and 11,472 controls, all of Chinese Han descent. We successfully identified four new loci for coronary artery disease reaching genome-wide significance (P < 5 × 10(−8)), which mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (PHACTR1, TCF21, CDKN2A/B and C12orf51). These findings provide new insights into biological pathways for the susceptibility of coronary artery disease in Chinese Han population
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021
The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth of multiomics data, CNCB-NGDC is continually expanding, updating and enriching its core database resources through big data deposition, integration and translation. In the past year, considerable efforts have been devoted to 2019nCoVR, a newly established resource providing a global landscape of SARS-CoV-2 genomic sequences, variants, and haplotypes, as well as Aging Atlas, BrainBase, GTDB (Glycosyltransferases Database), LncExpDB, and TransCirc (Translation potential for circular RNAs). Meanwhile, a series of resources have been updated and improved, including BioProject, BioSample, GWH (Genome Warehouse), GVM (Genome Variation Map), GEN (Gene Expression Nebulas) as well as several biodiversity and plant resources. Particularly, BIG Search, a scalable, one-stop, cross-database search engine, has been significantly updated by providing easy access to a large number of internal and external biological resources from CNCB-NGDC, our partners, EBI and NCBI. All of these resources along with their services are publicly accessible at https://bigd.big.ac.cn