Scott\u27s Addition Green Space Plan: Small Changes Making a Big Impact

Scott’s Addition is a fast growing, postindustrial neighborhood situated on the north side of West Broad street and bordering Henrico county to the west. The current building stock in Scott’s Addition consists of industrial and manufacturing buildings, and warehouses, much of which have been converted into multi-family residential buildings, commercial businesses, office and restaurant space (Neighborhood History, 2018). As a consequence of its original land use and zoning most of Scott’s Addition is dominated by concrete surface area and sprawling, one to two story building structures. Adaptive reuse of existing buildings has brought new investment and residents into the neighborhood however, the landscape has largely stayed the same. Most of Scott’s Addition is dominated by impervious surfaces including flat roofs, parking lots, and wide streets that directly contribute to increased urban heat. There is a direct correlation between a reduced latent heat production and green infrastructure or urban tree canopy coverage. This design plan provides the framework for implementation of small scale green space projects by businesses on private property and can be the catalyst for a neighborhood-wide green transformation in the Scott’s Addition neighborhood

Libbie & Grove Urban Design Plan

This plan was created for the City of Richmond Department of Planning and Development Review to serve as a recommendation for urban design improvements and suggested changes to zoning ordinances for the Libbie and Grove commercial area located in the Westhampton neighborhood. To begin, an in-depth demographic analysis was conducted for the Westhampton neighborhood. Special attention was paid to socioeconomic factors and trends in census tracts directly surrounding the Libbie and Grove commercial corridor. Based on these analyses and new development occurring in the Libbie and Grove commercial corridor, we were able to allocate six sites or “study areas” as candidates for redevelopment. All of these sites represent valuable areas within the Libbie and Grove commercial corridor. The sites were selected and designed with different intentions, but aim to create a complete streetscape for the commercial area. Based on this analysis and study, it is our recommendation that a new zoning code be implemented for the Libbie and Grove commercial area in order to codify form based design requirements in order to preserve and enhance a village feel at Grove and Libbie and promote compatible future development

NANS-mediated synthesis of sialic acid is required for brain and skeletal development

We identified biallelic mutations in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe developmental delay and skeletal dysplasia. Patient body fluids showed an elevation in N-acetyl-D-mannosamine levels, and patient-derived fibroblasts had reduced NANS activity and were unable to incorporate sialic acid precursors into sialylated glycoproteins. Knockdown of nansa in zebrafish embryos resulted in abnormal skeletal development, and exogenously added sialic acid partially rescued the skeletal phenotype. Thus, NANS-mediated synthesis of sialic acid is required for early brain development and skeletal growth. Normal sialylation of plasma proteins was observed in spite of NANS deficiency. Exploration of endogenous synthesis, nutritional absorption, and rescue pathways for sialic acid in different tissues and developmental phases is warranted to design therapeutic strategies to counteract NANS deficiency and to shed light on sialic acid metabolism and its implications for human nutrition

NANS-mediated synthesis of sialic acid is required for brain and skeletal development.

We identified biallelic mutations in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe developmental delay and skeletal dysplasia. Patient body fluids showed an elevation in N-acetyl-D-mannosamine levels, and patient-derived fibroblasts had reduced NANS activity and were unable to incorporate sialic acid precursors into sialylated glycoproteins. Knockdown of nansa in zebrafish embryos resulted in abnormal skeletal development, and exogenously added sialic acid partially rescued the skeletal phenotype. Thus, NANS-mediated synthesis of sialic acid is required for early brain development and skeletal growth. Normal sialylation of plasma proteins was observed in spite of NANS deficiency. Exploration of endogenous synthesis, nutritional absorption, and rescue pathways for sialic acid in different tissues and developmental phases is warranted to design therapeutic strategies to counteract NANS deficiency and to shed light on sialic acid metabolism and its implications for human nutrition