35,791 research outputs found
Exploring the challenges of implementing e-health: a protocol for an update of a systematic review of reviews.
There is great potential for e-health to deliver cost-effective, quality healthcare and spending on e-health systems by governments and healthcare systems is increasing worldwide. However, the literature often describes problematic and unsuccessful attempts to implement these new technologies into routine clinical practice. To understand and address the challenges of implementing e-health, a systematic review was conducted in 2009, which identified several conceptual barriers and facilitators to implementation. As technology is rapidly changing and new e-health solutions are constantly evolving to meet the needs of current practice, an update of this review is deemed necessary to understand current challenges to the implementation of e-health. This research aims to identify, summarise and synthesise currently available evidence, by undertaking a systematic review of reviews to explore the barriers and facilitators to implementing e-health across a range of healthcare settings
Reliability physics
Speakers whose topics relate to the reliability physics of solar arrays are listed and their topics briefly reviewed. Nine reports are reviewed ranging in subjects from studies of photothermal degradation in encapsulants and polymerizable ultraviolet stabilizers to interface bonding stability to electrochemical degradation of photovoltaic modules
The Business Environment of 1995 as Seen by Wisconsin Business Executives
Like many states, particularly those in the so-called rust bucket of the industrial north, Wisconsin is concerned about its business climate. A number of different steps with the potential to make Wisconsin\u27s business environment more hospitable have been taken. For example, the state income tax has been reduced; the state has partially funded a business development organization, Forward Wisconsin, to attract new companies to the area; and a state-appointed panel, the Wisconsin Strategic Development Commission, has filed its recommendations concerning the actions that should be considered in revitalizing the region\u27s business community. This article provides another perspective. It reports upon the views held by a sample of Wisconsin business executives concerning the nature of the business environment in 1995. Specifically, this paper reports on the perceptions held by 24 executives (mostly vice presidents of planning or marketing) from Wisconsin corporations. Because vice-presidents of planning and marketing are most responsible for translating environmental trends into strategic actions, we believe their vision of the general business climate in 1995 will be of keen interest to those concerned about the future of Wisconsin\u27s economy
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach. In light of this, here we aim to determine if degenerate PCR primers can detect aminoglycoside and β-lactam resistance genes in the gut microbiota of healthy adults, without the need for an initial culture-based screen for resistant isolates. In doing so, we would determine if the gut microbiota of healthy adults, lacking recent antibiotic exposure, is a reservoir for resistance genes.
Results: The strategy employed resulted in the identification of numerous aminoglycoside (acetylation, adenylation and phosphorylation) and β-lactam (including bla
OXA, bla TEM, bla SHV and bla CTX-M) resistance gene homologues. On the basis of homology, it would appear that these genes originated from different bacterial taxa, with members of the Enterobacteriaceae being a particularly rich source. The results demonstrate that, even in the absence of recent antibiotic exposure, the human gut microbiota is a considerable reservoir for antibiotic resistance genes.
Conclusions: This study has demonstrated that the gut can be a significant source of aminoglycoside and β-lactam resistance genes, even in the absence of recent antibiotic exposure. The results also demonstrate that PCR-based approaches can be successfully applied to detect antibiotic resistance genes in the human gut microbiota, without the need to isolate resistant strains. This approach could also be used to rapidly screen other complex environments for target genes.Fiona Fouhy is in receipt of an Irish Research Council EMBARK scholarship
and is a Teagasc Walsh fellow. Research in the PDC laboratory is also
supported by the Irish Government under the National Development Plan through the Science Foundation Ireland Investigator award 11/PI/113
UV Imaging Polarimetry of the Seyfert 2 Galaxy Mrk 3
We present UV imaging polarimetry data of the Seyfert 2 galaxy Mrk 3 taken by
the Hubble Space Telescope. The polarized flux is found to be extended to ~1
kpc from the nucleus, and the position angles of polarization are
centrosymmetric, confirming that the polarization is caused by scattering. We
determine the location of the hidden nucleus as the center of this
centrosymmetric pattern. From the polarization images taken in two broad bands,
we have obtained the color distribution of the polarized flux. Some regions
have blue polarized flux, consistent with optically-thin dust scattering, but
some bright knots have a color similar to that of Seyfert 1 nucleus. Also, the
recent Chandra X-ray observation suggests that the ratio of scattered UV flux
to scattered X-ray flux is rather similar to the intrinsic UV/X-ray ratio in a
Seyfert 1 nucleus, if the observed extended X-ray continuum is scattered light.
While the scattered X-ray would be essentially from electron scattering, the UV
slope and UV/X-ray ratio both being similar to Seyfert 1's would lead to two
possibilities as to the nature of the UV scatterers. One is that the UV may
also be scattered by electrons, in which case the scattering gas is somehow
dust-free. The other is that the UV is scattered by dust grains, but the
wavelength-independent UV scattering with low efficiency indicated by the UV
slope and UV/X-ray ratio would suggest that the grains reside in UV-opaque
clouds, or the dust might be mainly composed of large grains and lacks
small-grain population.Comment: 15 pages, 8 figures (plus 2 color versions of grayscale figures), To
appear in ApJ; minor corrections for the proofs of the manuscrip
Molecular Characterisation of Bacteriophage K Towards Applications for the Biocontrol of Pathogenic Staphylococci
End of project reportThe aim of this work was to characterise staphylococcal bacteriophage (a bacterial virus) and to assess their potential as therapeutic agents against pathogenic strains of Staphylococcus aureus, particularly mastitis-causing strains. The project included the use of two newly isolated phage CS1 and DW2, and an existing polyvalent phage. The new phage were isolated from the farmyard and characterised by electron microscopy and restriction analysis. Both phage were shown to belong to the Siphoviridae family and were lytic for representatives of all three clonal groups of Irish mastitis-associated staphylococci. A cocktail of three phage (CS1, DW2 and K) at 108 (plaque forming units) PFU/ml was infused into cows teats in animal trials. The lack of an increase in somatic cell counts in milks indicated strongly that the phage did not irritate the animal. In addition, the most potent phage used in this study, phage K, was further studied by genome sequencing, which revealed a linear DNA genome of 127,395 base pairs, which encodes 118 putative ORFs (open reading frames)
Non-isotropy in the CMB power spectrum in single field inflation
Contaldi et al. [1] have suggested that an initial period of kinetic energy
domination in single field inflation may explain the lack of CMB power at large
angular scales. We note that in this situation it is natural that there also be
a spatial gradient in the initial value of the inflaton field, and that this
can provide a spatial asymmetry in the observed CMB power spectrum, manifest at
low multipoles. We investigate the nature of this asymmetry and comment on its
relation to possible anomalies at low multipoles.Comment: 25 pages, 12 figures. In this revised version, we include the
Integrated Sachs-Wolfe effect, which was missing from the original. This
modifies some results in the low multipoles. The comparison with experiment
is slightly better but the change is not statistically significan
Quantum entanglement between a nonlinear nanomechanical resonator and a microwave field
We consider a theoretical model for a nonlinear nanomechanical resonator
coupled to a superconducting microwave resonator. The nanomechanical resonator
is driven parametrically at twice its resonance frequency, while the
superconducting microwave resonator is driven with two tones that differ in
frequency by an amount equal to the parametric driving frequency. We show that
the semi-classical approximation of this system has an interesting fixed point
bifurcation structure. In the semi-classical dynamics a transition from stable
fixed points to limit cycles is observed as one moves from positive to negative
detuning. We show that signatures of this bifurcation structure are also
present in the full dissipative quantum system and further show that it leads
to mixed state entanglement between the nanomechanical resonator and the
microwave cavity in the dissipative quantum system that is a maximum close to
the semi-classical bifurcation. Quantum signatures of the semi-classical
limit-cycles are presented.Comment: 36 pages, 18 figure
Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge
peer-reviewedLinks between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-induced obese (DIO) mice through manipulation of the gut microbiota with vancomycin or with the bacteriocin-producing probiotic Lactobacillus salivarius UCC118 (Bac+), with metabolic improvement achieved in DIO mice in receipt of vancomycin. However, two phases of weight gain were observed with effects most marked early in the intervention phase. Here, we compare the gut microbial populations at the early relative to the late stages of intervention using a high throughput sequencing-based analysis to understand the temporal relationship between the gut microbiota and obesity. This reveals several differences in microbiota composition over the intervening period. Vancomycin dramatically altered the gut microbiota composition, relative to controls, at the early stages of intervention after which time some recovery was evident. It was also revealed that Bac+ treatment initially resulted in the presence of significantly higher proportions of Peptococcaceae and significantly lower proportions of Rikenellaceae and Porphyromonadaceae relative to the gut microbiota of L. salivarius UCC118 bacteriocin negative (Bac-) administered controls. These differences were no longer evident at the later time. The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota.The authors are supported in part by Teagasc, Science Foundation Ireland (in the form of a research centre grant to the Alimentary Pharmabiotic Centre and PI awards to PWOT and PC) and by Alimentary Health Ltd
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