Justice Reinvestment in Alaska: The Past, Present, and Future of SB 91

In the summer of 2016, Alaska Governor Bill Walker signed SB 91, a landmark criminal justice reform law that implements a “justice reinvestment” program. SB 91 aims to reduce Alaska’s prison population, cut corrections costs, and then reinvest savings back into the state to improve public safety and reduce recidivism. It is 193 sections long and is likely the most substantial change to Alaskan criminal law since statehood. It also comes at a time when similar legislation, spearheaded by the Justice Reinvestment Initiative, is proliferating through the country. This Note overviews Alaska’s corrections problems that prompted SB 91, discusses the law’s legislative history, highlights some of the most important changes the law makes, and introduces some of the issues that it may present going forward

Energia da biomasse. Studio del funzionamento di un impianto di biodigestione anaerobica mesofila per 1 MW elettrico da biometano

Studio dell'esercizio per un impianto di biodigestione anaerobica che produce biogas, dimensionato in modo da soddisfare una centrale termoelettrica da 1 MW. Analisi di funzionamento sul lungo periodo, a partire dall'effettiva messa in esercizio, monitorando la risposta al variare delle biomasse alimentate. L'obiettivo finale è di ottenere un prospetto di funzionamento strutturato con approccio ingegneristico, che sia di completamento e verifica alle informaznioni fornite dal costruttore. Sono ricavate indicazioni sulla resa della produzione di biogas, sono verificati i principali parametri di esercizio (tempi di ritenzione, ecc) e sono sviluppate formule matematiche utili al monitoraggio di importanti variabili (y metano, consumi). il primo capitolo contiene un utile riassunto delle trasformazioni biochimiche che intervengono nel processo di biodigestione anaerobica mesofilaope

Informing policy via dynamic models: Cholera in Haiti

Public health decisions must be made about when and how to implement interventions to control an infectious disease epidemic. These decisions should be informed by data on the epidemic as well as current understanding about the transmission dynamics. Such decisions can be posed as statistical questions about scientifically motivated dynamic models. Thus, we encounter the methodological task of building credible, data-informed decisions based on stochastic, partially observed, nonlinear dynamic models. This necessitates addressing the tradeoff between biological fidelity and model simplicity, and the reality of misspecification for models at all levels of complexity. As a case study, we consider the 2010-2019 cholera epidemic in Haiti. We study three dynamic models developed by expert teams to advise on vaccination policies. We assess previous methods used for fitting and evaluating these models, and we develop data analysis strategies leading to improved statistical fit. Specifically, we present approaches to diagnosis of model misspecification, development of alternative models, and computational improvements in optimization, in the context of likelihood-based inference on nonlinear dynamic systems. Our workflow is reproducible and extendable, facilitating future investigations of this disease system.Comment: To be submitted to the Annals of Applied Statistic

Facile and sustainable functionalization of graphene layers with pyrrole compounds

A facile and sustainable functionalization of graphene layers was performed with pyrrole compounds (PyC) prepared through the Paal–Knorr reaction of a primary amine with 2,5-hexanedione. A good number of primary amines were used: hexanamine, dodecanamine, octadecanamine, 2-aminoacetic acid, 2-amino-1,3-propanediol, 3-(triethoxysilyl)propan-1-amine. The reactions were characterized by good yield, up to 96 %, and indeed satisfactory atom efficiency, up to 80 %. The functionalization of graphene layers was obtained by mixing PyC with a high surface area graphite and heating at a temperature range from 130 °C to 150 °C for 3 h. The yield of functionalization reaction was larger than 60 % and also up to about 90 % for the pyrrole compounds from dodecanamine and 2-amino-1,3-propanediol, respectively. The cycloaddition reaction between the graphene layers and the pyrrole compound, oxidized in two position, is proposed as working hypothesis to account for such efficient functionalization. Raman spectroscopy revealed that the structure of the graphitic substrate remained substantially unaltered, after the reaction. Stable dispersions of HSAG adducts with different PyC were prepared in solvents with different solubility parameters and HRTEM analysis showed the presence of aggregates of only few layers of graphene. Qualitative results of dispersion tests were used to calculate the Hansen sphere for the HSAG adduct with the pyrrole compound based on dodecanamine so to provide a first estimate of its Hansen solubility parameters. This work paves the way for the facile and sustainable modification of the solubility parameters of graphene layers and for the predictive assessment of their compatibility with different environments

Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus

AbstractObjectives: Calcineurin inhibitors reduce experimental reperfusion injury in the liver, brain, heart, kidney, and small bowel. These studies were undertaken to determine whether these agents are similarly protective against lung ischemia-reperfusion injury. Methods: Left lungs of male rats were rendered ischemic for 90 minutes and reperfused for as long as 4 hours. Treated animals received cyclosporine A (INN: ciclosporin; 1 or 5 mg/kg) or tacrolimus (0.2 mg/kg) 6 hours before ischemia, at reperfusion, or 2 hours after reperfusion. Injury was quantitated in terms of tissue polymorphonuclear leukocyte accumulation (myeloperoxidase content), vascular permeability (iodine 125-labeled bovine serum albumin extravasation), and bronchoalveolar lavage leukocyte content. Separate tissue samples were processed for nuclear protein and cytokine messenger RNA. Results: Treatment with cyclosporine (5 mg/kg) or tacrolimus (0.2 mg/kg) 6 hours before reperfusion reduced lung vascular permeability by 54% and 56% relative to control animals (P <.03). The protective effects of cyclosporine and tacrolimus treatment before reperfusion correlated with 42% and 43% reductions in tissue polymorphonuclear leukocyte (myeloperoxidase) content (P <.008) and marked reductions in bronchoalveolar lavage leukocyte accumulation (P <.01). Administration of cyclosporine or tacrolimus at the time of reperfusion or 2 hours into the reperfusion period offered little or no protection. Animals treated before reperfusion also demonstrated marked reductions in nuclear factor κB activation and expression of proinflammatory cytokine messenger RNA. Conclusion: Cyclosporine and tacrolimus treatment before reperfusion was protective against lung ischemia-reperfusion injury in rats. The mechanism of these protective effects may involve the inhibition of nuclear factor κB, a central transcription factor mediating inflammatory injury. The decreased expression of cytokine messenger RNA indicates that both cyclosporine and tacrolimus may exert their protective effects at the pretranscriptional level.J Thorac Cardiovasc Surg 2002;123:756-6

Assessing the validity of using serious game technology to analyze physician decision making

Background: Physician non-compliance with clinical practice guidelines remains a critical barrier to high quality care. Serious games (using gaming technology for serious purposes) have emerged as a method of studying physician decision making. However, little is known about their validity. Methods: We created a serious game and evaluated its construct validity. We used the decision context of trauma triage in the Emergency Department of non-trauma centers, given widely accepted guidelines that recommend the transfer of severely injured patients to trauma centers. We designed cases with the premise that the representativeness heuristic influences triage (i.e. physicians make transfer decisions based on archetypes of severely injured patients rather than guidelines). We randomized a convenience sample of emergency medicine physicians to a control or cognitive load arm, and compared performance (disposition decisions, number of orders entered, time spent per case). We hypothesized that cognitive load would increase the use of heuristics, increasing the transfer of representative cases and decreasing the transfer of non-representative cases. Findings: We recruited 209 physicians, of whom 168 (79%) began and 142 (68%) completed the task. Physicians transferred 31% of severely injured patients during the game, consistent with rates of transfer for severely injured patients in practice. They entered the same average number of orders in both arms (control (C): 10.9 [SD 4.8] vs. cognitive load (CL):10.7 [SD 5.6], p = 0.74), despite spending less time per case in the control arm (C: 9.7 [SD 7.1] vs. CL: 11.7 [SD 6.7] minutes, p<0.01). Physicians were equally likely to transfer representative cases in the two arms (C: 45% vs. CL: 34%, p = 0.20), but were more likely to transfer non-representative cases in the control arm (C: 38% vs. CL: 26%, p = 0.03). Conclusions: We found that physicians made decisions consistent with actual practice, that we could manipulate cognitive load, and that load increased the use of heuristics, as predicted by cognitive theory. © 2014 Mohan et al

Determining a Core Curriculum in Surgical Infections for Fellowship Training in Acute Care Surgery Using the Delphi Technique

Background: Recent data highlight the educational, financial, and healthcare benefits of acute care surgery (ACS). These data serve as the impetus to create ACS fellowships, which now are accredited by the American Association for the Surgery of Trauma. However, the core components of a curriculum fundamental for ACS training and that yield competence and proficiency have yet to be determined. Methods: Experts in ACS from the United States (n=86) were asked to propose topics in surgical infectious diseases of potential importance in developing a core curriculum for ACS fellowship training. They were then required to rank these topics in order of importance to identify those considered most fundamental. Results: Thirty-one filters ranking in the highest tertile are proposed as topics of surgical infectious diseases that are fundamental to any curriculum of ACS fellowship training. The majority pertains to aspects of thoracic infections (n=8), although topics of soft tissue infections (n=5) comprised four of the top 10 (40%) filters. Abdominal infections (n=6), the biology of sepsis (n=6), and risk, prevention, and prophylaxis (n=6) completed the list. Conclusion: This study identifies the most important topics of surgical infectious disease that merit consideration for incorporation into a core curriculum of ACS training. Hopefully, this information will assist in the development of ACS fellowships that optimize the training of future ACS surgeons.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140213/1/sur.2012.202.pd

Facile and sustainable functionalization method for preparing graphene layers with different solubility parameters

Graphene has exceptional properties: high charge-carrier mobilities, in-plane thermal conductivity, very high elastic modulus. Such properties essentially arise from the six atoms aromatic ring repeating unit of graphene layers. Hence, objective of graphene synthesis and functionalization should be to obtain and preserve such structure. Graphene functionalization has indeed great importance: electronic and solubility properties, self-assembly and phaseforming behaviour are affected by functional groups. In this work, a functionalization method was developed (1,2), able to introduce functional groups in peripheral positions of graphene layers, without appreciably altering graphene structure. Functionalization was performed by using molecules whose basic structure is shown in Figure 1. A pyrrole ring with different substituents on the nitrogen atom was used. Synthesis of these molecules was performed with high atom economy (larger than 80%), high yield (up to 99%) and thus high atom efficiency, the only byproduct being water, in the absence of solvent and catalyst (3). Reaction between such molecules and nanosized high surface area graphites was performed by simply mixing them, donating either mechanical or thermal energy. Functionalization occurred with almost quantitative yield. This process has a low environmental impact. Thanks to such functionalization method, solubility parameter of graphene layer was changed in a broad range, obtaining stable layers’ suspension in water, hexane, toluene. Form such suspensions, few layers graphenes were isolated. Moreover, even dispersions of graphene layers were prepared in polymer matrices such as poly(1,4-cis-isoprene), poly(styrene-cobutadiene), poly(urethane). This work presents a facile, sustainable, economically viable functionalization method of graphene layers, suitable for preparing few layers graphene from nanosized graphite and for matching the solubility parameters of polymer matrices, achieving even dispersions and intimate interactions