Coagulation-balance gene predictors influencing visual prognosis in patients treated with photodynamic therapy for classic choroidal neovascularization secondary to age-related macular degeneration.

PURPOSE: To determine whether different coagulation-balance genetic polymorphisms explain the variable clinical outcomes of photodynamic therapy with verteporfin (PDT-V) in Caucasian patients with classic or predominantly classic choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). METHODS: The clinical records of consecutive AMD patients with classic or predominantly classic CNV, treated with PDTV according to the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy study criteria, were retrospectively examined. Eighty-six eligible patients were subdivided in responder and non-responder basing on the modifications of best-corrected visual acuity between baseline and 12-month checks. Six gene polymorphisms, i.e. factor V G1691A, prothrombin G20210A, factor XIII-A G185T, methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, and methionine synthase reductase A66G, were genotyped in each patient. Binary logistic regression models were used to explore the predictive role of phenotypic and genotypic variables for PDT-V effectiveness. RESULTS: PDT-V responders were more prevalent among the combined carriers for factor V 1691A and prothrombin 20210A alleles (OR = 5.1 with a 95% CI of 1.0-24.4; P = 0.05), methylenetetrahydrofolate reductase 677 T-allele (OR = 4.3 with a 95% CI of 1.8-10.8; P = 0.002), and methionine synthase reductase 66 G-allele (OR = 2.8 with a 95% CI of 1.1-6.8; P = 0.04). Conversely, PDT-V non-responders were over-represented in patients with factor XIII-A 185 T-allele (OR = 0.22 with a 95% CI of 0.09-0.56; P = 0.001). The other considered predictors did not significantly modify PDT-V effectiveness. CONCLUSIONS: Our study provides evidences for the presence of pharmacogenetic relationship between peculiar coagulation-balance gene polymorphisms and different levels of visual prognosis at 12 months in AMD patients treated with standardized PDT-V protocol for classic subfoveal CNV

El "Mendozazo" en el contexto de la escisión ideológica nacional

Fil: Romano, Aníbal Mario. Universidad Nacional de Cuy

The Wave-Function Is a Multi-Field

It is generally argued that if the wave-function in the de Broglie--Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn't received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other field interpretations; third, we clarify common misconceptions

Cambiamenti nell’uso del suolo: analisi e comparazione di mappe storiche e recenti. Il caso della Valle dell’Agri, Basilicata, Italia

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The Wave-Function Is a Multi-Field

It is generally argued that if the wave-function in the de Broglie--Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn't received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other field interpretations; third, we clarify common misconceptions

The Wave-Function Is a Multi-Field

It is generally argued that if the wave-function in the de Broglie--Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn't received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other field interpretations; third, we clarify common misconceptions

Bilateral Keratectasia 34 Years after Corneal Transplant

We report the clinical findings of a patient with severe bilateral keratectasia 34 years after a penetrating keratoplasty (PK) in both eyes. An otherwise healthy 67-year-old man complained of deterioration of the eyesight in both eyes over the last 6 months. The patient was diagnosed with bilateral keratoconus at the age of 32 years, and he underwent a bilateral PK. At presentation, visual acuity was 20/200 in the right eye and light perception in the left eye. A Pentacam pachymetric map revealed a central pachymetry of 720 μm in the right eye and of 710 μm in the left eye, as well as an average paracentral pachymetry of 436 and 270 μm in the 9-mm zone in the right and the left eye, respectively. Corneal topography revealed bilateral irregular and asymmetric bowing with generalized steepening and high corneal power. We describe a case of bilateral keratectasia 34 years after PK in a patient who was originally diagnosed with bilateral keratoconus