Pseudo-coronary scenario of inflammatory viral cardiomyopathy

Cardiomyopathy is one of the most severe and complicated cardiovascular diseases which leads to development of acute and chronic heart failure. The progress in molecular biochemistry and genetics allows to significant enhancement of its diagnostics. New data has confirmed that cardiomyopathies represent a comple

Pseudo-coronary scenario of inflammatory viral cardiomyopathy

Cardiomyopathy is one of the most severe and complicated cardiovascular diseases which leads to development of acute and chronic heart failure. The progress in molecular biochemistry and genetics allows to significant enhancement of its diagnostics. New data has confirmed that cardiomyopathies represent a comple

Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart

Comparative study of changes in myocardial activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and capillary density distribution in the experimental models of diabetic and postinfarction damage of rat heart was performed. Data showed that decrease in LDH and SDH activities was observed in both pathologies which can suggest abnormal processes of glycolysis and oxidative phosphorylation in cardiac mitochondria. Activity of LDH and SDH in combined pathologies was comparative with the corresponding values of these parameters in control group. The authors hypothesize that these differences can be caused by specifics of myocardial vascularization. The results of the study showed that an increase in capillary density was found in all groups of rats with pathologies compared with control group. However, no significant differences in the intensity of angiogenesis processes were found between groups with pathologies

Use of autoleukocyte, labelled with 99mTc-exametazine for evaluation of inglammatory changes in myocardium

Our purpose was to study the possibilities of autoleukocyte, labelled in vitro with 99mTc-exametazine (99m Tc-HMPAO), in evaluation of inflammatory changes of myocardium at patients with persistent form of atrial fibrillation (AF).We examined 30 patients with idiopathic persistent form of AF. For identification of the inflammatory areas in a myocardium before ablation scintigraphy (SPECT) 99mTc-HMPAO – leucocytes was carried out. Upon completion of scanning a perfusion scintigraphy of a myocardium with a 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) («Tehnetril» 99mTc, JSC Diamed, Russia) in rest under the standard protocol was carried out. Pathologic accumulation of 99mTc-HMPAO-leukocytes in a myocardium was revealed at 6 (20%) of the examined patients. Sensitivity of SPECT with 99mTc-HMPAO-leukocytes in diagnostics of inflammatory changes of a myocardium, according to our data, was - 80%, specificity - 92%, diagnostic accuracy - 90%

Use of autoleukocyte, labelled with 99mTc-exametazine for evaluation of inglammatory changes in myocardium

Our purpose was to study the possibilities of autoleukocyte, labelled in vitro with 99mTc-exametazine (99m Tc-HMPAO), in evaluation of inflammatory changes of myocardium at patients with persistent form of atrial fibrillation (AF).We examined 30 patients with idiopathic persistent form of AF. For identification of the inflammatory areas in a myocardium before ablation scintigraphy (SPECT) 99mTc-HMPAO – leucocytes was carried out. Upon completion of scanning a perfusion scintigraphy of a myocardium with a 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) («Tehnetril» 99mTc, JSC Diamed, Russia) in rest under the standard protocol was carried out. Pathologic accumulation of 99mTc-HMPAO-leukocytes in a myocardium was revealed at 6 (20%) of the examined patients. Sensitivity of SPECT with 99mTc-HMPAO-leukocytes in diagnostics of inflammatory changes of a myocardium, according to our data, was - 80%, specificity - 92%, diagnostic accuracy - 90%

Isolated Atrial Fibrillation, Inflammation and Efficacy of Radiofrequency Ablation: Preliminary Insights Based on a Single-Center Endomyocardial Biopsy Study

The aim of the study was to evaluate the inflammatory changes in the myocardium, based on endomyocardial biopsy (EMB) data in patients undergoing radiofrequency ablation (RFA) for idiopathic atrial fibrillation (AF). A total of 67 patients with idiopathic AF were enrolled in the study. Patients underwent the intracardiac examination, RFA of AF, and EMB with histological and immunohistochemical studies. The catheter-treatment effectiveness, and occurrence of early and late recurrences of atrial tachyarrhythmias, were assessed depending on the identified histological changes. Nine patients (13.4%) did not have any histological changes in the myocardium according to EMB. Fibrotic changes were detected in 26 cases (38.8%). Inflammatory changes according to the Dallas criteria were observed in 32 patients (47.8%). The follow-up period for patients averaged 19.3 ± 3.7 months. The effectiveness rates of primary RFA were 88.9% in patients with the intact myocardium, 46.2% in patients with fibrotic changes of varying severity, and 34.4% in patients with the presence of criteria for myocarditis. No early recurrence of arrhythmias was observed in patients with unchanged myocardia. The presence of inflammatory and fibrotic changes in the myocardium increased the rates of early and late arrhythmia recurrences and accordingly halved the effectiveness RFA of AF