Kinetics of Ehrlich ascites tumor growth within millipore chambers in normal and immunized mice.

THE proliferation of malignant cells has been shown to depend not only on intrinsic neoplastic properties but also on environmental circumstances, in vivo (host) or in vitro (medium). In addition, a changing rate of growth in a continuing environment has been documented in tumor-bearing hosts and tissue culture situations. The kinetics of neoplastic cells (i.e. Ehrlich ascites tumor cells-EAT) have been studied with regard to cellular proliferation within cell-tight millipore chambers by Amos and Wakefield (1958) (among others), particularly concerning the growth rate of cells in normal mice and the rate of entry of iso-antibody into the chambers. The present investigations define the growth pattern of Ehrlich ascites tumor cells within the restricted environment of millipore chambers in actively immunized mice. MATERIALS AND METHODS White Swiss mice of both sexes (HA/ICR strain), 3-4 months old, were used in this study. The tumor cells used were Lettre strain, hyperdiploid Ehrlich ascites tumor originally obtained from Roswell Park Memorial Institute and grow

Unveiling a Population of X-ray Non-Detected AGN

We define a sample of 27 radio-excess AGN in the Chandra Deep Field North by selecting galaxies that do not obey the radio/infrared correlation for radio-quiet AGN and star-forming galaxies. Approximately 60% of these radio-excess AGN are X-ray undetected in the 2 Ms Chandra catalog, even at exposures of > 1 Ms; 25% lack even 2-sigma X-ray detections. The absorbing columns to the faint X-ray-detected objects are 10^22 cm^-2 < N_H < 10^24 cm^-2, i.e., they are obscured but unlikely to be Compton thick. Using a local sample of radio-selected AGN, we show that a low ratio of X-ray to radio emission, as seen in the X-ray weakly- and non-detected samples, is correlated with the viewing angle of the central engine, and therefore with obscuration. Our technique can explore the proportion of obscured AGN in the distant Universe; the results reported here for radio-excess objects are consistent with but at the low end of the overall theoretical predictions for Compton-thick objects.Comment: Accepted for publication in the Astrophysical Journal, 15 pages, 10 figures, 4 table

Why Optically--Faint AGN Are Faint: The Spitzer Perspective

Optically--faint X-ray sources (those with f_X/f_R > 10) constitute about 20% of X-ray sources in deep surveys, and are potentially highly obscured and/or at high redshift. Their faint optical fluxes are generally beyond the reach of spectroscopy. For a sample of 20 optically--faint sources in CDFS, we compile 0.4--24 um photometry, relying heavily on Spitzer. We estimate photometric redshifts for 17 of these 20 sources. We find that these AGN are optically--faint both because they lie at significantly higher redshifts (median z ~ 1.6) than most X-ray--selected AGN, and because their spectra are much redder than standard AGN. They have 2--8 keV X-ray luminosities in the Seyfert range, unlike the QSO--luminosities of optically--faint AGN found in shallow, wide--field surveys. Their contribution to the X-ray Seyfert luminosity function is comparable to that of z>1 optically--bright AGN.Comment: Accepted for publication in the Astrophysical Journa

Recent and future trends in synthetic greenhouse gas radiative forcing

Atmospheric measurements show that emissions of hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons are now the primary drivers of the positive growth in synthetic greenhouse gas (SGHG) radiative forcing. We infer recent SGHG emissions and examine the impact of future emissions scenarios, with a particular focus on proposals to reduce HFC use under the Montreal Protocol. If these proposals are implemented, overall SGHG radiative forcing could peak at around 355 mW m[superscript −2] in 2020, before declining by approximately 26% by 2050, despite continued growth of fully fluorinated greenhouse gas emissions. Compared to “no HFC policy” projections, this amounts to a reduction in radiative forcing of between 50 and 240 mW m[superscript −2] by 2050 or a cumulative emissions saving equivalent to 0.5 to 2.8 years of CO2 emissions at current levels. However, more complete reporting of global HFC emissions is required, as less than half of global emissions are currently accounted for.Natural Environment Research Council (Great Britain) (Advanced Research Fellowship NE/I021365/1)United States. National Aeronautics and Space Administration (Upper Atmospheric Research Program Grant NNX11AF17G)United States. National Oceanic and Atmospheric Administratio

Spitzer Power-law AGN Candidates in the Chandra Deep Field-North

We define a sample of 62 galaxies in the Chandra Deep Field-North whose Spitzer IRAC SEDs exhibit the characteristic power-law emission expected of luminous AGN. We study the multiwavelength properties of this sample, and compare the AGN selected in this way to those selected via other Spitzer color-color criteria. Only 55% of the power-law galaxies are detected in the X-ray catalog at exposures of >0.5 Ms, although a search for faint emission results in the detection of 85% of the power-law galaxies at the > 2.5 sigma detection level. Most of the remaining galaxies are likely to host AGN that are heavily obscured in the X-ray. Because the power-law selection requires the AGN to be energetically dominant in the near- and mid-infrared, the power-law galaxies comprise a significant fraction of the Spitzer-detected AGN population at high luminosities and redshifts. The high 24 micron detection fraction also points to a luminous population. The power-law galaxies comprise a subset of color-selected AGN candidates. A comparison with various mid-infrared color selection criteria demonstrates that while the color-selected samples contain a larger fraction of the X-ray luminous AGN, there is evidence that these selection techniques also suffer from a higher degree of contamination by star-forming galaxies in the deepest exposures. Considering only those power-law galaxies detected in the X-ray catalog, we derive an obscured fraction of 68% (2:1). Including all of the power-law galaxies suggests an obscured fraction of < 81% (4:1).Comment: Accepted for publication in the Astrophysical Journal, 27 pages, 20 figures, 5 tables, version with high-resolution figures and online-only tables available at: http://frodo.as.arizona.edu/~jdonley/powerlaw

Spitzer and Hubble Constraints on the Physical Properties of the z~7 Galaxy Strongly Lensed by Abell 2218

We report the detection of a z~7 galaxy strongly lensed by the massive galaxy cluster Abell 2218 (z=0.175) at 3.6 and 4.5 um using the Spitzer Observatory and at 1.1 um using the Hubble Space Telescope. The new data indicate a refined photometric redshift in the range of 6.6-6.8 depending on the presence of Ly-alpha emission. The spectral energy distribution is consistent with having a significant Balmer break, suggesting that the galaxy is in the poststarburst stage with an age of at least ~50 Myr and quite possibly a few hundred Myr. This suggests the possibility that a mature stellar population is already in place at such a high redshift. Compared with typical Lyman break galaxies at z~3-4, the stellar mass is an order of magnitude smaller (~10^{9} Msun), but the specific star formation rate (star formation rate/M_{star}) is similarly large (> 10^{-9} yr^{-1}), indicating equally vigorous star-forming activity.Comment: 11 pages, 2 figures, 2 tables; Accepted for publication in ApJ

The Population of Weak Mg II Absorbers I. A Survey of 26 QSO HIRES/Keck Spectra

We present a search for "weak" MgII absorbers [those with W_r(2796) < 0.3 A in the HIRES/Keck spectra of 26 QSOs. We found 30, of which 23 are newly discovered. The spectra are 80% complete to W_r(2796) = 0.02 A and have a cumulative redshift path of ~17.2 for the redshift range 0.4 < z < 1.4. The number of absorbers per unit redshift, dN/dz, is seen to increase as the equivalent width threshold is decreased; we obtained dN/dz = 1.74+/-0.10 for our 0.02 <= W_r(2796) < 0.3 A sample. The equivalent width distribution follows a power law with slope -1.0; there is no turnover down to W_r(2796) = 0.02 A at = 0.9. Weak absorbers comprise at least 65% of the total MgII absorption population, which outnumbers Lyman limit systems (LLS) by a factor of 3.8+/-1.1; the majority of weak MgII absorbers must arise in sub-LLS environments. Tentatively, we predict that ~5% of the Lyman-alpha forest clouds with W_r(1215) > 0.1 A will have detectable MgII absorption to W_r,min(2796) = 0.02 A and that this is primarily a high-metallicity selection effect (Z/Z_sun] > -1). This implies that MgII absorbing structures figure prominently as tracers of sub-LLS environments where gas has been processed by stars. We compare the number density of W_r(2796) > 0.02 A absorbers with that of both high and low surface brightness galaxies and find a fiducial absorber size of 35h^-1 to 63h^-1 kpc, depending upon the assumed galaxy population and their absorption properties. The individual absorbing "clouds" have W_r(2796) <= 0.15 A and their narrow (often unresolved) line widths imply temperatures of ~25,000 K. We measured W_r(1548) from CIV in FOS/HST archival spectra and, based upon comparisons with FeII, found a range of ionization conditions (low, high, and multi-phase) in absorbers selected by weak MgII.Comment: Accepted Version: 43 pages, PostScript figures embedded; accepted to ApJ; updated version includes analysis of CIV absorptio

Is Rust Used Safely by Software Developers?

Rust, an emerging programming language with explosive growth, provides a robust type system that enables programmers to write memory-safe and data-race free code. To allow access to a machine's hardware and to support low-level performance optimizations, a second language, Unsafe Rust, is embedded in Rust. It contains support for operations that are difficult to statically check, such as C-style pointers for access to arbitrary memory locations and mutable global variables. When a program uses these features, the compiler is unable to statically guarantee the safety properties Rust promotes. In this work, we perform a large-scale empirical study to explore how software developers are using Unsafe Rust in real-world Rust libraries and applications. Our results indicate that software engineers use the keyword unsafe in less than 30% of Rust libraries, but more than half cannot be entirely statically checked by the Rust compiler because of Unsafe Rust hidden somewhere in a library's call chain. We conclude that although the use of the keyword unsafe is limited, the propagation of unsafeness offers a challenge to the claim of Rust as a memory-safe language. Furthermore, we recommend changes to the Rust compiler and to the central Rust repository's interface to help Rust software developers be aware of when their Rust code is unsafe