3,681 research outputs found
Realisation of genomic selection in the honey bee
Genomische Selektion ist ein Routine-Verfahren bei verschiedenen Nutztierarten, aber noch nicht bei der Honigbiene wegen der Besonderheiten dieser Spezies. FĂŒr die ZuchtwertschĂ€tzung bei der Honigbiene ist eine spezielle genetische Verwandtschaftsmatrix erforderlich, da die Paarungsbiologie dieser Spezies ungesicherte Vaterschaft, diploide Königinnen und haploide Drohnen umfasst. Die Arbeit prĂ€sentiert einen neu-entwickelten Algorithmus zur effizienten Berechnung der Inversen der genetischen Verwandtschaftsmatrix und der Inzuchtkoeffizienten auf groĂen DatensĂ€tzen. Die Methode wurde zur Voraussage von genomischen und Stammbaum-basierten Zuchtwerten in einer Simulationsstudie genutzt. Die Genauigkeit und die Verzerrung der geschĂ€tzten Zuchtwerte wurden ausgewertet unter BerĂŒcksichtigung verschiedener GröĂen der Referenzpopulation. AuĂerdem wurde der Zuchtfortschritt im ersten Durchlauf von Zuchtprogrammen ausgewertet, die Zuchtschemata mit genomischer oder Stammbaum-basierter Selektion nutzten. Ein erheblich gröĂerer Zuchtfortschritt als bei Stammbaum-basierter Selektion wurde mit genomischer Vorselektion erzielt, fĂŒr die junge Königinnen genotypisiert wurden, und nur die Kandidaten mit den höchsten genomischen Zuchtwerten zur Anpaarung oder LeistungsprĂŒfung zugelassen wurden. FĂŒr einen realen Datensatz von ungefĂ€hr 3000 genotypisierten Königinnen wurden Stammbaum-basierte und genomische Zuchtwerte fĂŒr sechs wirtschaftlich bedeutende Merkmale vorhergesagt. Drei Merkmale zeigten eine signifikant höhere Vorhersagegenauigkeit bei genomischer ZuchtwertschĂ€tzung gegenĂŒber Stammbaum-basierten Verfahren und die Unterschiede zwischen allen sechs Merkmalen konnten im Wesentlichen aus den genetischen Parametern der Merkmale und der begrenzten GröĂe der Referenzpopulation erklĂ€rt werden. Damit zeigt die Arbeit, dass die genomische Selektion bei der Honigbiene genutzt werden kann, den Zuchtfortschritt zu erhöhen.Genomic selection is a routine practice for several important livestock species but not yet in honey bees, due to the peculiarities of this species. For honey bees, a specialized genetic relationship matrix is required for the prediction of breeding values, since their mating biology involves uncertain paternity, diploid queens, and haploid drones. The thesis presents a novel algorithm for the efficient computation of the inverse of the numerator relationship matrix and the coefficients of inbreeding on large data sets. The method was used to estimate genomic and pedigree-based breeding values in a simulation study. The accuracy and bias of the estimated breeding values were evaluated and various sizes of the reference population were considered. Subsequently, the genetic gain in the initial cycle of breeding programs was evaluated for several breeding schemes employing genomic or pedigree-based selection. A considerably higher genetic gain than with pedigree-based selection was achieved with genomic preselection, for which queens were genotyped early in life, and only the candidates of high genomic breeding value were admitted for mating or phenotyping. On a real data set of about 3000 genotyped queens, pedigree-based and genomic breeding values were predicted for six economically relevant traits. Three traits showed significantly higher prediction accuracy with genomic compared to pedigree-based methods, and the differences between all the six traits could be explained mainly from their genetic parameters and the limited size of the reference population. The results show that genomic selection can be applied in honey bees, and the thesis provides appropriate breeding schemes and mathematical methods for its implementation
Obscenity - Liquor Regulations; California v. LaRue
The state has the power to regulate the distribution of liquor and enforce health and safety regulations, but the state may not broadly stifle First Amendment freedoms when doing so. The breath of legislative abridgement must be viewed in the light of less drastic means for achieving the same basic purpose. s The Court has consistently held that only a compelling state interest in the regulation of a subject within the state\u27s constitutional power to regulate can justify limiting First Amendment freedoms
Review of Alexander Nehamas, The Art of Living: Socratic Reflections from Plato to Foucault.
Alexander Nehamas, Review of The Art of Living: Socratic Reflections from Plato to Foucault. Berkeley: University of California Press, 1998. 283 pp. ISBN 0520211731
Review of Jan Assmann, Religion and Cultural Memory, trans. Rodney Livingstone.
Jan Assmann, Religion and Cultural Memory, trans. Rodney Livingstone. Stanford: Stanford University Press, 2006. x + 222 pp. ISBN 0804745234
Quantum Mechanical (Phase Shift) Analysis of Differential Elastic Scattering of Molecular Beams
For a spherically symmetrical intermolecular potential V(r)=Ï”f(r/Ï) the quantum calculation of the elastic scattering cross section dÏ(Î)/dΩ in the c.m. system is carried out as follows. For a given relative velocity (or deBroglie wavelength) and an assumed V(r), the radial wave equation is integrated for successive values of the angular momentum quantum number l, yielding the phase shifts ηÎč. Then dÏ(Î)dΩ is computed in terms of the series of ηÎč's in the standard way. A general computational program (following that of K. Smith) is outlined for the evaluation of the radial wave function and the phase shifts, utilizing an IBM 704 computer. Calculations are presented for the LâJ (12, 6) potential function. The results may be concisely represented using the framework provided by the semiclassical treatment of Ford and Wheeler, i.e., in terms of a set of reduced phase constants vs reduced angular momenta at various reduced relative kinetic energies K. Tables and graphs are presented from which the phases may be obtained, to a good approximation, for any given Ï”, Ï and K. Computation of the differential and total cross sections from the phase shifts is then readily accomplished.The results are compared with the classical and semiclassical treatments. The problem of tunneling and orbiting is discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70444/2/JCPSA6-33-3-795-1.pd
Review of Remnants of Auschwitz: The Witness and the Archive, trans. Daniel Heller-Roazen
Giorgio Agamben, Remnants of Auschwitz: The Witness and the Archive, trans. Daniel Heller-Roazen New York: Zone Books, 1999. 175 pp. ISBN 189051161265
HighâVelocity Molecular Beam Scattering: Total Elastic Cross Sections for LâJ(n, 6) and Expâ6(α) Potentials
Explicit expressions are derived for the total elastic scattering cross sections in the highâvelocity region for molecules interacting according to LâJ (n, 6) and expâ6(α) potentials. Cross sections are presented in tabular and graphical form.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70237/2/JCPSA6-38-2-515-1.pd
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