898 research outputs found
Fish fatty acids and mental health in older people
Background It has been suggested that the intake of fish and marine n-3 polyunsaturated fatty acids could protect against age-related cognitive decline and impaired mental well-being. However, results from observational studies are inconclusive and data from randomized controlled trials in older people without clinical dementia or depression are scarce. The objective of this thesis was to investigate the effect of daily supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on cognitive performance and mental well-being in an older non-clinical population. We also examined the effect of fish oil on gene expression profiles in white blood cells to identify early changes in pathways possibly related to mental health. Furthermore, we assessed the association of fish and EPA+DHA intake with mental health in different aging populations. Methods The effect of low and high doses of EPA+DHA (400 and 1,800 mg per day, respectively) on cognitive performance, several measures of mental well-being, and gene expression was examined in a 26-week randomized, double-blind, placebo-controlled trial. This study was conducted in 302 individuals aged 65 years or older with no clinical diagnosis of dementia or depression. Furthermore, the cross-sectional association between fatty fish and EPA+DHA intake with cognitive performance and the association with cognitive change during 6 years of follow-up was assessed in 1,025 aging US men who participated in the Veterans Affairs Normative Aging Study (NAS). In addition, the associations of EPA+DHA and fish intake with depressive symptoms and dispositional optimism were assessed in 644 free-living Dutch subjects with a history of myocardial infarction. Results Daily intake of low or high doses of EPA+DHA did not affect cognitive performance, mental well-being, anxiety, or quality of life, after 13 or 26 weeks of intervention. However, treatment with EPA+DHA for 26 weeks altered gene expression in white blood cells to a more anti-inflammatory and more anti-atherogenic profile. In elderly US men we found no association of fatty fish or EPA+DHA intake with cognitive performance or 6-year cognitive change. Intake of EPA+DHA was positively associated with dispositional optimism in subjects with a history of myocardial infarction. There was also a tendency for less depressive symptoms with a higher EPA+DHA or fish intake, but this association was no longer statistically significant after controlling for confounders. Conclusion Supplemental intake of EPA+DHA is unlikely to have a short-term impact on cognitive performance or mental well-being of older people without a clinical diagnosis of dementia or depression. Whether long-term intake of EPA+DHA and fish could be beneficial to the maintenance of cognitive performance or mental well-being of older people in Western populations still needs to be established. <br/
Made to Order: A Preliminary Review of Crime Risk Assessments in New South Wales, Australia
In 2001, guidelines were introduced in New South Wales (NSW) to ensure that proposed developments/redevelopments of the built environment reflected key crime prevention through environmental design (CPTED) principles. The guidelines state that in certain circumstances a crime risk assessment report is required on the proposed development. To date, these guidelines have not been evaluated, making it impossible to assess their impact and the utility of the associated crime risk assessment reports. Partially to address this gap, a small number (four) of publicly available crime risk assessment reports have been reviewed and key issues highlighted here. In particular, the relevance of some aspects of these reports is questioned, as is the impact of the relationship between the client (i.e. developer) commissioning the report and the âindependentâ consultant. The small sample of risk assessment reports reviewed here cannot be considered representative of the larger body of such reports. Further research is required to determine the veracity of the findings of this small review.Sydney Institute of Criminology; School of Social Sciences at the University of Western Sydne
Wideband precision stabilization of the -18.6kV retarding voltage for the KATRIN spectrometer
The Karlsruhe Tritium Neutrino Experiment (KATRIN) measures the effective
electron anti-neutrino mass with an unprecedented design sensitivity of 0.2 eV
(90 % C.L.). In this experiment, the energy spectrum of beta electrons near the
tritium decay endpoint is analyzed with a highly accurate spectrometer. To
reach the KATRIN sensitivity target, the retarding voltage of this spectrometer
must be stable to the ppm level and well known on various time scales (
up to months), for values around -18.6 kV. A custom-designed high-voltage
regulation system mitigates the impact of interference sources in the absence
of a closed electric shield around the large spectrometer vessel. In this
article, we describe the regulation system and its integration into the KATRIN
setup. Independent monitoring methods demonstrate a stability within 2 ppm,
exceeding KATRIN's specifications.Comment: 28 pages, 17 figures, minor improvement
A pulsed, mono-energetic and angular-selective UV photo-electron source for the commissioning of the KATRIN experiment
The KATRIN experiment aims to determine the neutrino mass scale with a
sensitivity of 200 meV/c^2 (90% C.L.) by a precision measurement of the shape
of the tritium -spectrum in the endpoint region. The energy analysis of
the decay electrons is achieved by a MAC-E filter spectrometer. To determine
the transmission properties of the KATRIN main spectrometer, a mono-energetic
and angular-selective electron source has been developed. In preparation for
the second commissioning phase of the main spectrometer, a measurement phase
was carried out at the KATRIN monitor spectrometer where the device was
operated in a MAC-E filter setup for testing. The results of these measurements
are compared with simulations using the particle-tracking software
"Kassiopeia", which was developed in the KATRIN collaboration over recent
years.Comment: 19 pages, 16 figures, submitted to European Physical Journal
SDSS J124602.54+011318.8: A Highly Variable AGN, Not an Orphan GRB Afterglow
The optically variable source SDSS J124602.54+011318.8 first appears in Sloan
Digital Sky Survey (SDSS) data as a bright point source with nonstellar colors.
Subsequent SDSS imaging and spectroscopy showed that the point source declined
or disappeared, revealing an underlying host galaxy at redshift 0.385. Based on
these properties, the source was suggested to be a candidate ``orphan
afterglow'': a moderately beamed optical transient, associated with a gamma-ray
burst (GRB) whose highly beamed radiation cone does not include our line of
sight. We present new imaging and spectroscopic observations of this source.
When combined with a careful re-analysis of archival optical and radio data,
the observations prove that SDSS J124602.54+011318.8 is in fact an unusual
radio-loud AGN, probably in the BL Lac class. The object displays strong
photometric variability on time scales of weeks to years, including several
bright flares, similar to the one initially reported. The SDSS observations are
therefore almost certainly not related to a GRB. The optical spectrum of this
object dramatically changes in correlation with its optical brightness. At the
bright phase, weak, narrow oxygen emission lines and probably a broader
H line are superposed on a blue continuum. As the flux decreases, the
spectrum becomes dominated by the host galaxy light, with emerging stellar
absorption lines, while both the narrow and broad emission lines have larger
equivalent widths. We briefly discuss the implications of this discovery on the
study of AGNs and other optically variable or transient phenomena.Comment: 14 pages, 5 figures, AASTEX 5.0.2, slight modifications following
referee's report, PASP, in pres
Tycho Brahe's 1572 supernova as a standard type Ia explosion revealed from its light echo spectrum
Type Ia supernovae (SNe Ia) are thermonuclear explosions of white dwarf stars
in close binary systems. They play an important role as cosmological distance
indicators and have led to the discovery of the accelerated expansion of the
Universe. Among the most important unsolved questions are how the explosion
actually proceeds and whether accretion occurs from a companion or via the
merging of two white dwarfs. Tycho Brahe's supernova of 1572 (SN 1572) is
thought to be one of the best candidates for a SN Ia in the Milky Way. The
proximity of the SN 1572 remnant has allowed detailed studies, such as the
possible identification of the binary companion, and provides a unique
opportunity to test theories of the explosion mechanism and the nature of the
progenitor. The determination of the yet unknown exact spectroscopic type of SN
1572 is crucial to relate these results to the diverse population of SNe Ia.
Here we report an optical spectrum of Tycho Brahe's supernova near maximum
brightness, obtained from a scattered-light echo more than four centuries after
the direct light of the explosion swept past Earth. We find that SN 1572
belongs to the majority class of normal SNe Ia. The presence of a strong Ca II
IR feature at velocities exceeding 20,000 km/s, which is similar to the
previously observed polarized features in other SNe Ia, suggests asphericity in
SN 1572.Comment: 15 pages, 3 figures - accepted for publication in Natur
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