Effects of simulated error-sources on different 3-D CSI-EPT strategies

Three-dimensional contrast source inversion-electrical properties tomography (3-D CSI-EPT) is an iterative reconstruction method that estimates the electrical properties of tissue from transmit field magnetic resonance data. However, in order to bring 3-D CSI-EPT into practice for complex tissue structures and to understand the origin and effect of errors, insight in the sensitivities of reconstruction accuracy to the major error-sources is necessary. In this paper, different strategies for implementing 3-D CSI-EPT, including their iterative structure, are presented, of which the regularized implementation shows the most potential to be used in practice. Moreover, the influence of initialization, noise, stopping criteria, incident fields, B1-maps, transceive phase and domain truncation are discussed. We show that of all these different error-sources, initialization, accurate coil models and domain truncation have the most dramatic effect on electrical properties reconstructions in practice.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Design, characterisation and performance of an improved portable and sustainable low-field MRI system

Low-field permanent magnet-based MRI systems are finding increasing use in portable, sustainable and point-of-care applications. In order to maximize performance while minimizing cost many components of such a system should ideally be designed specifically for low frequency operation. In this paper we describe recent developments in constructing and characterising a low-field portable MRI system for in vivo imaging at 50 mT. These developments include the design of i) high-linearity gradient coils using a modified volume-based target field approach, ii) phased-array receive coils, and iii) a battery-operated three-axis gradient amplifier for improved portability and sustainability. In addition, we report performance characterisation of the RF amplifier, the gradient amplifier, eddy currents from the gradient coils, and describe a quality control protocol for the overall system.Radiolog

Reduced-order modeling of transient electromagnetic fields

Electrical Engineering, Mathematics and Computer Scienc

Low-frequency model-order reduction of electromagnetic fields without matrix factorization

Electrical Engineering, Mathematics and Computer Scienc

Learning a preconditioner to accelerate compressed sensing reconstructions in MRI

Purpose: To learn a preconditioner that accelerates parallel imaging (PI) and compressed sensing (CS) reconstructions. Methods: A convolutional neural network (CNN) with residual connections was used to train a preconditioning operator. Training and validation data were simulated using 50% brain images and 50% white Gaussian noise images. Each multichannel training example contains a simulated sampling mask, complex coil sensitivity maps, and two regularization parameter maps. The trained model was integrated in the preconditioned conjugate gradient (PCG) method as part of the split Bregman CS method. The acceleration performance was compared with that of a circulant PI-CS preconditioner for varying undersampling factors, number of coil elements and anatomies. Results: The learned preconditioner reduces the number of PCG iterations by a factor of 4, yielding a similar acceleration as an efficient circulant preconditioner. The method generalizes well to different sampling schemes, coil configurations and anatomies. Conclusion: It is possible to learn adaptable preconditioners for PI and CS reconstructions that meet the performance of state-of-the-art preconditioners. Further acceleration could be achieved by optimizing the network architecture and the training set. Such a preconditioner could also be integrated in fully learned reconstruction methods to accelerate the training process of unrolled networks.Circuits and System

Generalized Signal Models and Direct FID-Based Dielectric Parameter Retrieval in MRI

In this article, we present full-wave signal models for magnetic and electric field measurements in magnetic resonance imaging (MRI). Our analysis is based on a scattering formalism in which the presence of an object or body is taken into account via an electric scattering source. We show that these signal models can be evaluated, provided that Green's tensors of the background field are known along with the dielectric parameters of the object and the magnetization within the excited part of the object. Furthermore, explicit signal expressions are derived in the case of a small homogeneous ball that is embedded in free space and for which the quasi-static Born approximation can be applied. The conductivity and permittivity of the ball appear as explicit parameters in the resulting signal models and allow us to study the sensitivity of the measured signals with respect to these dielectric parameters. Moreover, for free induction decay signals, we show through simulations that, under certain conditions, it is possible to retrieve the dielectric parameters of the ball from noise-contaminated induction decay signals that are based on electric or magnetic field measurements. Accepted author manuscriptCircuits and System

Limitations of 2-D Field Structure Assumptions in Electrical Properties Tomography and its 3-D CSI-EPT Solution

CSI-EPT is an Electrical Properties Tomography (EPT) reconstruction method that uses a Contrast Source Inversion (CSI) optimization approach to retrieve the conductivity and permittivity profiles of tissue based on -data. The method can handle variations in tissue profiles and was originally implemented for profile reconstructions in the midplane of a birdcage coil, where the RF field exhibits an E-polarized field structure [1]. Recently, CSI-EPT has been extended to a fully 3-D volumetric reconstruction method that is generally applicable (in- or outside the midplane) and no particular field structure or smoothness is assumed [2]. This is a major step towards turning CSI-EPT into a practical reconstruction method. Unfortunately, the computation times significantly increase (hours or even days, depending on the reconstruction domain of interest) and from this point of view a 2-D approach may be preferable. We show, however, that a 2-D approach is only warranted under very specific circumstances and having an E-polarized field structure is a necessary but not sufficient condition. In particular, we show that to obtain accurate tissue reconstructions based on 3-D -data, it is in general necessary to take all electromagnetic field components into account and a 2-D reconstruction approach will lead to reconstruction artefacts

A theoretical approach based on electromagnetic scattering for analysing dielectric shimming in high-field MRI

Radiolog

Modal analysis of photonic and plasmonic resonators

Determining the electromagnetic field response of photonic and plasmonic resonators is a formidable task in general. Field expansions in terms of quasi-normal modes (QNMs) are often used, since only a few of these modes are typically required for an accurate field description. We show that by exploiting the structure of Maxwell’s equations, conjugate-symmetric frequency-domain field expansions can be efficiently computed via a Lanczos-type algorithm. Dominant QNMs can be identified a posteriori with error control and without a priori mode selection. Discrete QNM approximations of resonating nanostructures are presented and the spontaneous decay rate of a quantum emitter is also considered.Circuits and System