COVID-19 : EFFECT ON LUNG CANCER PROGRESS

The advent of corona virus disease 2019 (COVID-19) has caused confusion, changed people's living conditions, including commuting restrictions, fear of disease transmission, The corona virus is  "Aladdin's meracle lamp" for lungs cancer, this is a huge curse for lung cancer patients. As the Root of entry of Virus is Respiratory tract,Complicaion arises in lungs. The risk of chemotherapy-related infections increases for such patients.  "Targeted therapy is generally safe while the potential interaction between immunotherapy and COVID-19 remains unknown at present”. The Present article focus on Different Immunological fact related to COVID-19 and Physiological degradation of Lungs by Corona Virus and Effect on Lung cancer

COMPUTER AIDED DRUG DESIGN: TOOLS TO DEVELOP DRUG FOR COVID 19

The CADD includes the combined use of modern computational and experimental techniques which provide structural information about the biologically active molecules. These molecules are involved in disease process and in modulating disease process. The processes of CADD methods are dependent on Bioinformatics tools, applications and database. The present Review article highlights how the modern computational and experimental techniques that have been developed in recent years can be used together to provide structural information about the biologically active molecules that are involved in disease process and in modulating disease process in Special focus to Drug designing for COVID 19 by virtual Screening. Out Put of the article: The present article may be one tool for new drug development against corona Virus

EVALUATION OF ANTIHYPERGLYCAEMIC EFFECT OF BUTEA MONOSPERMA LEAF EXTRACT ON ADRENALIN INDUCED AND HIGH GLUCOSE FEED ANIMAL MODEL

Objective: As per the ethnopharmacological information has Butea monosperma been used to treat diabetes mellitus by the tribal people of tropical and subtropical areas. However, there is no much more scientific report available about the antidiabetic property of the leaves of the plant. Hence, the study was undertaken to evaluate the antidiabetic effect of ethanolic extract of B. monosperma on blood levels of adrenaline-induced and glucose feed diabetic rabbits.Methods: The three different doses of the extracts (100, 200, and 400 mg/kg) were administered orally to an experimental animal. The animals were induced diabetics by adrenaline and high glucose diet. Blood glucose level was measured accordingly. For antidiabetic activity, photocolorimeter was used to monitoring the blood glucose level with crest kit box (GOP-POD method).Results: The extracts showed considerable dose-dependent activity. However, the dose 400 mg/kg showed considerable lower of blood glucose level. p<0.01 indicates the significance result. 8 hrs reading 182.5±3.83 for 400 mg does is most effective for reducing blood sugar.Conclusion: The study indicates that the ethanolic extract of B. monosperma leaves possesses antidiabetic properties which suggest the presence of biologically active components

INHIBITION OF GLUCOSE LOWERING EFFECT OF SITAGLIPTIN ON CONCURRENT USE WITH AMLODIPINE ON ADRENALINE INDUCED HYPERGLYCEMIC CARDIOTOXIC RAT

ABSTrACT   Objective- Sitagliptin is the first and only prescription medication in a new class of oral antihyperglycemic agents, which enhance the body's own ability to lower blood glucose when it is elevated. As many diabetic hypertensive patients taking amlodipine, the present study was undertaken to explore the effect of amlodipine on glucose lowering effect of Sitagliptin on adrenaline induced hyperglycemic cardiotoxic rats. Methods- Both acute and chronic effect of the drug combination was studied on adrenaline induced hyperglycemic cardiotoxic rats. In acute study, only glucose level was observed whereas in chronic study both glucose and lactate dehydrogenase (LDH) was estimated and heart was subjected to histopathological examination. Result- The glucose levels were increased significantly (p<.05) in adrenaline induced rats. Sitagliptin displayed significant reduction in rise in glucose level. The glucose level also significantly increased in rats where both Sitagliptin and amlodipine administered in both acute and chronic study. The rise in LDH level was also more in combination group in comparison to Sitagliptin alone. Conclusion- From the present study, it can be concluded that amlodipine inhibits glucose lowering effect of Sitagliptin in adrenaline induced hyperglycemic cardiotoxic rats.   Keywords- Sitagliptin, Amlodipine, adrenaline, glucose, cardiotoxicity

EVALUATION OF ANTIHYPERGLYCAEMIC EFFECT OF BUTEA MONOSPERMA LEAF EXTRACT ON ADRENALIN INDUCED AND HIGH GLUCOSE FEED ANIMAL MODEL

Objective: As per the ethnopharmacological information has Butea monosperma been used to treat diabetes mellitus by the tribal people of tropical and subtropical areas. However, there is no much more scientific report available about the antidiabetic property of the leaves of the plant. Hence, the study was undertaken to evaluate the antidiabetic effect of ethanolic extract of B. monosperma on blood levels of adrenaline-induced and glucose feed diabetic rabbits.Methods: The three different doses of the extracts (100, 200, and 400 mg/kg) were administered orally to an experimental animal. The animals were induced diabetics by adrenaline and high glucose diet. Blood glucose level was measured accordingly. For antidiabetic activity, photocolorimeter was used to monitoring the blood glucose level with crest kit box (GOP-POD method).Results: The extracts showed considerable dose-dependent activity. However, the dose 400 mg/kg showed considerable lower of blood glucose level. p<0.01 indicates the significance result. 8 hrs reading 182.5±3.83 for 400 mg does is most effective for reducing blood sugar.Conclusion: The study indicates that the ethanolic extract of B. monosperma leaves possesses antidiabetic properties which suggest the presence of biologically active components

A Review of Methods and Applications for a Heart Rate Variability Analysis

Heart rate variability (HRV) has emerged as an essential non-invasive tool for understanding cardiac autonomic function over the last few decades. This can be attributed to the direct connection between the heart’s rhythm and the activity of the sympathetic and parasympathetic nervous systems. The cost-effectiveness and ease with which one may obtain HRV data also make it an exciting and potential clinical tool for evaluating and identifying various health impairments. This article comprehensively describes a range of signal decomposition techniques and time-series modeling methods recently used in HRV analyses apart from the conventional HRV generation and feature extraction methods. Various weight-based feature selection approaches and dimensionality reduction techniques are summarized to assess the relevance of each HRV feature vector. The popular machine learning-based HRV feature classification techniques are also described. Some notable clinical applications of HRV analyses, like the detection of diabetes, sleep apnea, myocardial infarction, cardiac arrhythmia, hypertension, renal failure, psychiatric disorders, ANS Activity of Patients Undergoing Weaning from Mechanical Ventilation, and monitoring of fetal distress and neonatal critical care, are discussed. The latest research on the effect of external stimuli (like consuming alcohol) on autonomic nervous system (ANS) activity using HRV analyses is also summarized. The HRV analysis approaches summarized in our article can help future researchers to dive deep into their potential diagnostic applications

MOESM1 of Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicidin upon conjugation with CNT, in human monocytes

Additional file 1: Table S1. List of primers used to validate microarray through q-RTPCR

MOESM1 of Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicidin upon conjugation with CNT, in human monocytes

Additional file 1: Table S1. List of primers used to validate microarray through q-RTPCR

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films

In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a composition-dependent manner. As evident from the thermal analysis, COS content profoundly impacted the evaporation of water molecules from the composite films. Stress relaxation studies demonstrated that the blend films exhibited more mechanical stability as compared to the control film. The impedance profiles indicated the capacitive-dominant behavior of the prepared films. Ciprofloxacin HCl-loaded films showed excellent antimicrobial activity against Escherichia coli and Bacillus cereus. The prepared films were observed to be biocompatible. Hence, the prepared PVA/COS-based blend films may be explored for drug delivery applications

MOESM2 of Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicidin upon conjugation with CNT, in human monocytes

Additional file 2: Table S2. Gene expression in terms of fold changes following treatment with free LL37, conjugates and other relevant controls