7 research outputs found
Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats
Background: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggered by free radicals and produce collagen. Melatonin is a powerful physiologic scavenger of hydroxyl radicals. It is also involved in the inhibitory regulation of the collagen content in tissue. There is no effective treatment available for liver fibrosis. Our objective was to evaluate the effects of melatonin on liver fibrosis induced by bile-duct ligation (BDL) in rats
Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats
Background: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggered by free radicals and produce collagen. Melatonin is a powerful physiologic scavenger of hydroxyl radicals. It is also involved in the inhibitory regulation of the collagen content in tissue. There is no effective treatment available for liver fibrosis. Our objective was to evaluate the effects of melatonin on liver fibrosis induced by bile-duct ligation (BDL) in rats
Oncocytic carcinoma of the breast: frequency, morphology and follow-up
Oncocytic breast carcinomas are tumors composed of no fewer than 70% of oncocytic
cells (World Health Organization). The purpose of this study was to determine the
frequency, morphologic, immunohistochemical, and clinical features of invasive
oncocytic carcinoma in a large series. Twenty-eight cases of putative oncocytic
breast carcinoma (selected cases group) and 76 consecutive cases of invasive
breast carcinoma (consecutive cases group) were analyzed. Immunohistochemistry
for mitochondria, gross cystic disease fluid protein 15, chromogranin, estrogen
receptor, progesterone receptor, androgen receptor, HER2/Neu, cytokeratin 7,
cytokeratin 14, epithelial membrane antigen, and differentiation cluster 68 was
performed. Score for mitochondria was based on intensity and percentage of
immunopositive cells. Classes were as follows: (1) oncocytic carcinoma: at least
70%, 3+; (2) mitochondrion-rich carcinoma: 50% to 70%, 3+, or more than 50%, 2+;
and (3) all the other cases were referred to as invasive breast carcinoma.
Ultrastructural examination was available for 6 cases of oncocytic carcinoma.
Morphologic and immunohistochemical features of the 3 groups were compared using
Fisher exact test (P < .05). For overall survival analysis, Kaplan-Maier curves
were compared using log-rank and Wilcoxon tests (P < .05). Our results suggest
that oncocytic breast carcinoma is a morphologic entity with distinctive
histologic and ultrastructural features. Mitochondrion-rich carcinomas are
histologically similar to oncocytic carcinomas and constitute 19.7% of all
invasive carcinomas, indicating that cytoplasmic eosinophilia in breast cancer
cells is often due to accumulation of mitochondria. Oncocytic carcinomas and
mitochondrion-rich carcinomas are more often grade III tumors and show human
epidermal growth factor receptor 2 overexpression. Clinical features and overall
survival of oncocytic carcinomas are not distinctive because they are similar to
those of the other cases when matched for grade and stage