Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones

A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity

Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones

252-257A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity

PTSA CATALYZED KSF SOLID SUPPORTED MICHAEL ADDITION ON STYRYLISOXAZOLES AND THEIR REDUCTIVE CYCLIZATION TO AZEPINES

Abstract The Michel addition of styrylisoxazoles with ethyl benzoyl acetate in presence of ptoluene sulfonic acid (PTSA) catalyst supported on KSF solid furnished the Michael adducts in excellent yields in short time. The Michael adducts underwent reductive cyclization on treatment with SnCl 2 -MeOH to afford isoxazolo [4,5-b] azepines in high yields

Solid state reactions of some isoxazole derivatives

674-677Interaction of Schiffs bases of 4-amino-3-methyl-5- styrylisoxazole with m-CPBA in solid state furnishes secondary amides. The reaction of 4-amino-3-methyl-5-styrylisoxazole with phthalic anhydride, maleic anhydride and succinic anhydride in solid state gives the products with an opening of anhydride rings. The resulting products are cyclized by using acetic anhydride

Microwave assisted rapid and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro-2,1-benzisoxazoles

749-753A simple, extremely fast and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro2,1-benzisoxazoles has been achie­ved under microwave irradiation

An elegant synthesis of isoxazolyl 1-oxa-6-thia-4,9-diazaspiro[4.4]non-2-en-8-ones and 1,6-dithia-4,9-diazaspiro[4.4]non-7-en-3-ones

519-525A simple and highly efficient one-pot three-component procedure for the synthesis of isoxazolyl 1,3-oxa/thia-2-ylidene-N-aryl amines is described. These compounds have been further subjected to cyclocondensation to afford title compounds

Synthesis of some new isoxazolyldihydro[1,2,4]triazolo[1,5-<i style="mso-bidi-font-style:normal">b</i>] isoxazoles and dihydroimidazo[4,5-<i style="mso-bidi-font-style:normal">b</i>]indolylisoxazoles as possible biodynamic agents

677-685Synthesis of new isoxazolyl[1,2,4]triazolo[1,5-b]isoxazoles and imidazo[4,5-b]indolyl isoxazoles have been achieved by interaction of isoxazole Schiff base with isoxazole amines and isatin respectively