Del nudo a la trama : el proyecto de acompañamiento a las trayectorias académicas estudiantiles de la FCPyS

La educación superior afronta actualmente, tanto a nivel nacional como regional, la existencia de altas tasas de deserción, bajo rendimiento académico y reducidas tasas de egreso. Los índices de rendimiento académico negativo o rendimiento académico mínimo tienden a aumentar año a año, sobre todo a partir de la incorporación de nuevos sectores y la democratización de buena parte del acceso al nivel universitario. Tal situación cuestiona fuertemente los supuestos de trayectorias y recorridos académicos lineales, constantes e ininterrumpidos dejando entrever un complejo escenario donde se entrecruzan trayectos previos, factores personales, sociales e institucionales que atraviesan y condicionan el paso de los estudiantes por la universidad. Desde el año 2012 la FCPYS lleva adelante el proyecto “waika" en el marco del Programa Trayectorias Académicas Estudiantiles (TRACES). El mismo tiene por objetivo la articulación con la escuela media y el acompañamiento en el ingreso, permanencia y egreso de los estudiantes de la UNCuyo. El presente trabajo intenta realizar un recorrido por los proyectos desarrollados por el equipo de orientación de nuestra facultad durante los últimos años en la búsqueda de promover el ingreso, la permanencia y el egreso de los estudiantes en la FCPyS. Nuestro trabajo se centra en el reconocimiento de tres tramos principales dentro de las trayectorias académicas estudiantiles: Ingreso y Primer Año, Tramo Intermedio y Tramo Final. Tal clasificación se sostiene en los diagnósticos realizados y en la identificación de problemáticas y situaciones particulares por las que transitan los estudiantes en cada uno de dichos momentos.Fil: Raimondi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Maturano, Karen . Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociale

Conservación del Venado de las Pampas (Ozotoceros bezoarticus leucogaster) en los bajos submeridionales de Santa Fe, Argentina: un índice para monitorear factores de amenaza y su implementación en el período 1998-2009

La población santafesina de Ozotoceros bezoarticus, es la más pequeña y amenazada de Argentina. Su estado crítico requiere de un monitoreo continuo, y de acciones efectivas de conservación que sean direccionadas con el mejor criterio posible. En este trabajo se propone un índice de amenazas (IA) para un monitoreo periódico, siendo éste de fácil empleo, tanto para la toma de información a campo como para su análisis en gabinete y su interpretación. Se seleccionaron 8 amenazas directas o factores que las favorecen, y el área de distribución actual fue grillada con 29 celdas de 25 km2. Cada celda posee su propio IA, indicando finalmente qué celda está más afectada por factores de amenaza que otras. Se implementó el IA usando información de los años 1998, 2003 y 2009. Se encontró un aumento de celdas con IAs altos o muy altos entre períodos analizados. Respecto a la distribución de celdas con diferente nivel priorizado de IA, se observó que las principales áreas que presentan mayores presiones para la especie resultan las periferias, lindando a las rutas provinciales. Contrastando los IAs y la distribución recientemente de O. bezoarticus, se indica como prioridad: a) disminuir presiones en cuatro celdas (19, 20, 21 y 22) a fin de evitar una probable fragmentación de la población por presiones antropogénicas; b) trabajar sobre las celdas con Medio y Bajo IA (principalmente las celdas 5, 6, 7, 9, 10, 11, 12, 15, 16 y 17) a fin de que no se incrementen presiones a la especie; y c) trabajar en la erradicación de Sus scrofa en las celdas 7, 10, 11, 12, 17, 22, 26 y 27.Fil: Pautasso, Andrés. Museo Provincial de Ciencias Naturales “Florentino Ameghino”; ArgentinaFil: Raimondi, Vanina Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Li Puma, María Cecilia. Secretaría de Ambiente y Desarrallo Sustentable de la Nación; Argentin

The configuration of Sociology as curricular content and a subject in education

Este artículo tiene el propósito de compartir algunos hallazgos sobre la configuración de las disciplinas de las carreras como espacio o contenido escolar en el sistema educativo de la Provincia de Mendoza, en particular, las modelizaciones pedagógicas de las prácticas de residencia de la cohorte 2006 del profesorado de Sociología. Así, la unidad de indagación fueron nueve Portafolios y sus Memorias en los que se documentaron y narraron dieciocho experiencias de prácticas de residencias desarrolladas durante el ciclo lectivo 2006. Este aporte está organizado en cuatro apartados. En el primero, se describen los dispositivos de trabajo de la cátedra en torno a la organización de las experiencias de residencias de los estudiantes del profesorado (2004-2013). En el segundo, se caracterizan los rasgos de los Portafolios y Memorias de prácticas y cursantes de la cohorte 2006 del Profesorado de Sociología. En el tercer apartado, se ensaya una caracterización de las modelizaciones pedagógicas emergentes, y se presta especial atención a la descripción de sus rasgos. Finalmente, en el cuarto, se proponen una serie de reflexiones en torno a los hallazgos obtenidos y a algunas líneas de indagación emergentes.This article intends to share some findings about the configuration of certain courses’ disciplines as curricular content and subjects within the education system of Mendoza province, more specifically, the kind of pedagogical modeling used in the residence training of the Sociology Teacher Training student group in 2006. Nine Portfolios and their Memoirs were subjected to analysis in which, at the same time, eighteen experiences of residency training practices carried out during the 2006 academic year were documented and narrated. This collective work is organized into four sections. In the first one, we describe the working procedures of the professorship centering on the arrangement of the residency training experiences of the teacher training students (2004-2013). In the second section, we characterize the features of the Portfolios and Memoirs of the practices and students that were part of the teacher training in Sociology in 2006. In the third segment, we perform a characterization of the arising pedagogical modeling while paying particular attention to the description of its features. Finally, in the fourth and last section, we propose a number of considerations regarding the findings and some emerging lines of enquiry.Fil: Elgueta, Martín. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Ficcardi, Marcela. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Lami, Liliana. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Pessino, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Raimondi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Mercado, Graciela. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociale

Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats

We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).Facultad de Ciencias Médica

Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats

We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).Facultad de Ciencias Médica

Antifungal, phyto, cyto, genotoxic and lipophilic properties of three complexes of sulfadimethoxine (HSDM) with Ag(I). Synthesis and characterization of [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O

Fungal infections are still a major problem. Some limitations of current antifungals (toxicity, fungal resistance) require the search for new drugs. The interest in metal–sulfanilamide derivatives was stimulated by the successful introduction of a silver-sulfadiazine complex, yet in current use, to prevent microbial infections during burn treatment of both humans and animals. Sulfadimethoxine (HSDM) is used in medicine, most frequently veterinary, to treat many infections, such as respiratory, urinary, etc. In this work we report the synthesis, characterization by elemental analysis, FTIR, 1H NMR and 13C NMR spectra of the heteroleptic complexes [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O, named as AgSDM-SCN and AgSDM-phen, respectively, and the biological properties (lipophilicity, antifungal, phyto, cyto and genotoxicity) of AgSDM-SCN, AgSDM-phen and the homoleptic one: AgSDM. 1H NMR spectra show that the sulfonamide moiety loses its acidic proton in both complexes, in agreement with the FTIR results. The three complexes showed a moderate antifungal activity, mainly against the yeasts Candida albicans, C. tropicalis and Cryptococcus neoformans. None of the tested fungi was inhibited by the free ligand. Lipophilicity: log Koctanol/water values were 0.80, 0.84, 0.85, 0.94 and 0.43 for HSDM, NaSDM, AgSDM, AgSDM-SCN and AgSDM-phen respectively, similarly to another sulfa-metal complexes. No genotoxicity or cytotoxicity were observed for AgSDM and AgSDM-SCN in the Allium cepa test, different from AgSDM-phen. Given these results, the studied complexes could be good candidates for further pharmaceutical studies.Fil: Mosconi, Natalia Ester. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Monti, Laura Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Giulidori, Cecilia María del Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Raimondi, Marcela Patricia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Bellú, Sebastián Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Rizzotto, Marcela Adriana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentin

Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1

Background: Deregulation of transcription in the pathogenesis of sporadic Amyotrophic Lateral Sclerosis (sALS) is taking central stage with RNA-sequencing analyses from sALS patients tissues highlighting numerous deregulated long non-coding RNAs (lncRNAs). The oncogenic lncRNA ZEB1-AS1 is strongly downregulated in peripheral blood mononuclear cells of sALS patients. In addition, in cancer-derived cell lines, ZEB1-AS1 belongs to a negative feedback loop regulation with hsa-miR-200c, acting as a molecular sponge for this miRNA. The role of the lncRNA ZEB1-AS1 in sALS pathogenesis has not been characterized yet, and its study could help identifying a possible disease-modifying target. Methods: the implication of the ZEB1-AS1/ZEB1/hsa-miR-200c/BMI1 pathway was investigated in multiple patients-derived cellular models (patients-derived peripheral blood mononuclear cells and induced pluripotent stem cells-derived neural stem cells) and in the neuroblastoma cell line SH-SY5Y, where its function was inhibited via RNA interference. Molecular techniques such as Real Time PCR, Western Blot and Immunofluorescence were used to assess the pathway dysregulation. Results: Our results show a dysregulation of a signaling pathway involving ZEB1-AS1/hsa-miR-200c/β-Catenin in peripheral blood mononuclear cells and in induced pluripotent stem cells-derived neural stem cells from sALS patients. These results were validated in vitro on the cell line SH-SY5Y with silenced expression of ZEB1-AS1. Moreover, we found an increase for ZEB1-AS1 during neural differentiation with an aberrant expression of β-Catenin, highlighting also its aggregation and possible impact on neurite length. Conclusions: Our results support and describe the role of ZEB1-AS1 pathway in sALS and specifically in neuronal differentiation, suggesting that an impairment of β-Catenin signaling and an alteration of the neuronal phenotype are taking place

Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats

We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).Facultad de Ciencias Médica

Outstanding Survival and Regeneration Process by the Use of Intelligent Acellular Dermal Matrices and Mesenchymal Stem Cells in a Burn Pig Model

A pig model with a deep large burn was used to study the regeneration process induced by mesenchymal stem cells (MSCs) and acellular pig dermal matrices, made intelligent by the combination with biodegradable nanofibers loaded with growth factors (granulocitemacrophage colony-stimulating factor and epidermal growth factor) and coated with the anti-CD44 monoclonal antibody (intelligent acellular dermal matrices, IADMs). These IADMs are specially designed to integrate in the wound bed as new biological scaffolds as well as to specifically recruit and attach circulating and/or externally applied MSCs through the anti-CD44 antibody while delivering precise amounts of growth factors. In this way, the reparative process as well as the aesthetic and functional results were enhanced in our burn model. The animal survived, the wound was completely closed, and total regeneration of the skin was obtained without much scarring. Surprisingly, hair follicles and other skin appendages developed despite the severity and deepness of the burn. Even burned muscles and ribs seemed to have undergone a regenerative process by the end of the study. Based on these findings, we have proposed the use of IADMs and autologous, allogeneic or xenogeneic MSCs, as a new paradigm for the future treatment of large burns and probably other dermatological and cosmetic human conditions.Facultad de Ciencias Médica

A GEP-ISFG collaborative study on the optimization of an X-STR decaplex: data on 15 Iberian and Latin American populations

Abstract In a collaborative work carried out by the Spanish and Portuguese ISFG Working Group (GEPISFG), a polymerase chain reaction multiplex was optimized in order to type ten X-chromosome short tandem repeats (STRs) in a single reaction, including: DXS8378, DXS9902, DXS7132, DXS9898, DXS6809, DXS6789 DXS7133, GATA172D05, GATA31E08, and DXS7423. Using this X-decaplex, each 17 of the participating laboratories typed a population sample of approximately 200 unrelated individuals (100 males and 100 females). In this work, we report the allele frequencies for the ten XSTRs in 15 samples from Argentina (Buenos Aires, Córdoba, Río Negro, Entre Ríos, and Misiones), Brazil (São Paulo, Rio de Janeiro, Paraná, and Mato Grosso do Sul), Colombia (Antioquia), Costa Rica, Portugal (Northern and Central regions), and Spain (Galicia and Cantabria). Gene diversities were calculated for the ten markers in each population and all values were above 56%. The average diversity per locus varied between 66%, for DXS7133, and 82%, for DXS6809. For this set of STRs, a high discrimination power was obtained in all populations, both in males (≥1 in 5×105) and females (≥1 in 3×109), as well as high mean exclusion chance in father/daughter duos (≥99.953%) and in father/mother/daughter trios (≥99.999%). Genetic distance analysis showed no significant differences between northern and central Portugal or between the two Spanish samples from Galicia and Cantabria. Inside Brazil, significant differences were found between Rio de Janeiro and the other three populations, as well as between São Paulo and Paraná. For the five Argentinean samples, significant distances were only observed when comparing Misiones with Entre Ríos and with Río Negro, the only two samples that do not differ significantly from Costa Rica. Antioquia differed from all other samples, except the one from Río Negro.Fil: Gusmão, Leonor. Universidad de Porto; PortugalFil: Sánchez Diz, Paula. Universidad de Santiago de Compostela; EspañaFil: Alves, Cíntia. Universidad de Porto; PortugalFil: Gomes, Iva. Universidad de Porto; PortugalFil: Zarrabeitia, María Teresa. Universidad de Cantabria; EspañaFil: Abovich, Mariel. Ministerio de Ciencia, Tecnología e Innovación Productiva. Banco Nacional de Datos Genéticos; ArgentinaFil: Atmetlla, Ivannia. Laboratorio de Análisis Clínicos y Moleculares; Costa RicaFil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Bravo, Luisa. Laboratorio Genes; ColombiaFil: Builes, Juan. Laboratorio Genes; ColombiaFil: Cainé, Laura. Instituto Nacional de Medicina Legal; PortugalFil: Calvo, Raquel. Universidad de Santiago de Compostela; EspañaFil: Carvalho, Elizeu. Universidade do Estado do Rio de Janeiro; BrasilFil: Carvalho, Mónica. Instituto Nacional de Medicina Legal; PortugalFil: Cicarelli, Regina. Universidade Estadual Paulista; BrasilFil: Catelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Espinoza, Marta. Unidad de Genética Forense; Costa RicaFil: García Monasterio, Óscar. Area de Laboratorio Ertzaintza; EspañaFil: Malaghini, Marcelo. Laboratorio Frischmann Aisengart ; BrasilFil: Martins, Joyce. Universidade Estadual Paulista; BrasilFil: Pinheiro, Fátima. Instituto Nacional de Medicina Legal; PortugalFil: Porto, Maria João. Instituto Nacional de Medicina Legal; PortugalFil: Raimondi, Eduardo Humberto. Fundación Favaloro; ArgentinaFil: Riancho, Jose Antonio. Universidad de Cantabria; EspañaFil: Rodríguez, Amelia. Universidad de Santiago de Compostela; EspañaFil: Rodríguez, Anayanci. Universidad de Santiago de Compostela; EspañaFil: Rodríguez Cardozo, Belén. Ministerio de Ciencia, Tecnología e Innovación Productiva. Banco Nacional de Datos Genéticos; ArgentinaFil: Schneider, Vicente. Laboratorio Frischmann Aisengart; BrasilFil: Silva, Sandra. Laboratorio de Análisis Clínicos y Moleculares; Costa RicaFil: Tavares, Celso. Universidade do Estado do Rio de Janeiro; BrasilFil: Toscanini, Ulises Faustino. Fundación Favaloro; ArgentinaFil: Vullo, Carlos. No especifíca;Fil: Whittle, Martin. Genomic Engenharia Molecular; BrasilFil: Yurrebaso, Iñaki. Laboratorio Ertzaintza; EspañaFil: Carracedo, Ángel. Universidad de Santiago de Compostela; EspañaFil: Amorim, António. Universidad de Porto; Portuga