Preferred antiretroviral drugs for the next decade of scale up

Global commitments aim to provide antiretroviral therapy (ART) to 15 million people living with HIV by 2015, and recent studies have demonstrated the potential for widespread ART to prevent HIV transmission. Increasingly, countries are adapting their national guidelines to start ART earlier, for both clinical and preventive benefits. To maximize the benefits of ART in resource-limited settings, six key principles need to guide ART choice: simplicity, tolerability and safety, durability, universal applicability, affordability and heat stability. Currently available drugs, combined with those in late-stage clinical development, hold great promise to simplify treatment in the short term. Over the longer-term, newer technologies, such as long-acting formulations and nanotechnology, could radically alter the treatment paradigm. This commentary reviews recommendations made in an expert consultation on treatment scale up in resource-limited settings

Hepatitis C in HIV-infected individuals: a systematic review and meta-analysis of estimated prevalence in Africa

Although hepatitis C virus (HCV) screening is recommended for all HIV-infected patients initiating antiretroviral therapy, data on epidemiologic characteristics of HCV infection in resource-limited settings are scarce

La recherche à l'épreuve de l'éthique : vers un nouveau modèle ?

International audienc

Toward a global health approach: lessons from the HIV and Ebola epidemics

Abstract Background The imposing burden of non-communicable diseases, emerging infectious diseases, climate change, environmental consequences, migrations, urbanization, and other challenges, faced in a context that strives to make universal health coverage (UHC) a reality, compels global health professionals to ask: how do we construct a “global” roadmap that is both realistic and effective? To move forward and begin to answer this question, we draw on lessons and experiences gained during the “global” health crises triggered by the HIV and Ebola pandemics. Main text Improving the early response and committing to the long haul; developing inter-disciplinary and inter-sectoral responses; designing comprehensive and versatile interventions; and, most importantly, to work closely and effectively with civil society and communities are some of the critical elements that were identified. The health sector has changed dramatically in recent years; new tools and innovative technologies are transforming the culture and practice of public health. This calls for a new vision. Reprioritizing primary health care and community engagement, repositioning approaches to meet people’s needs, applying integrated disease management to respond to problems caused by the silo approach, implementing UHC, and ensuring equity are some of the new strategies. Conclusion These strategies must all undergo a mandatory revolution in health governance—locally and globally. It should be obvious that nothing can be improved on a global or sustainable scale without re-examining the architecture and governance of major funding and international organizations dedicated to health. Pressing economic, demographic, and climate issues related to health underscore the urgent need for these changes

Nouvelles haches perforées de la Haute-Saône et des départements voisins

Demesy M., Huguenin G., Raguin Emile, Thévenin André. Nouvelles haches perforées de la Haute-Saône et des départements voisins. In: Bulletin de la Société préhistorique française. Études et travaux, tome 64, n°2, 1967. pp. 339-346

Dans l’ombre du VIH/SIDA : les maladies oubliées de l’Afrique sub-saharienne. Quels enjeux sanitaires ? Quelle responsabilité des bailleurs de fonds ?

Sous l’effet de l’épidémie de VIH/Sida, l’aide internationale pour la santé a connu un accroissement exceptionnel ces dernières années. La pandémie reste lourde de conséquences sanitaires, socio-économiques et politiques fragilisant les pays les plus pauvres et en particulier ceux d’Afrique subsaharienne. La solidarité déployée est incontestable mais la lutte contre le VIH/Sida s’est affichée peu à peu comme la priorité de l’agenda sanitaire international. Face à l’ampleur de cette aide, que deviennent les autres enjeux de santé qui menacent cette région du monde et quelles sont les conséquences d’une telle polarisation ? Cet article porte un regard sur les pathologies oubliées du continent sous-Africain, analyse les contradictions des financements actuels en matière de santé et propose de nouvelles stratégies dans une perspective de santé globale durable et équitable

The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept

International audienceOne of the challenges to improve radiotherapy is to increase cancer· cells radiosensit ivity. Using nanocarriers, concentration of chemotherapy drugs into cancer cells could be improved. Titanate nanotubes (TiONts) presented Interesting properties as needle shape, large specific surface, many hydroxide groups at physiological pH. These particularities could be useful for their interactions with the cellular environment while they increase the possibilities of grafting. The interest of TiONts associated with ·radiotherapy was evaluated in radioresistant human glioblastoma cell lines in an in vitro model

Leishmania major cutaneous leishmaniasis in HIV-positive patients does not spread to extralesional sites

International audienc

Leishmania major cutaneous leishmaniasis in HIV-positive patients does not spread to extralesional sites

International audienc