Geometric scaling in ultrahigh energy neutrinos and nonlinear perturbative QCD

It is shown that in ultrahigh energy inelastic neutrino-nucleon(nucleus) scattering the cross sections for the boson-hadron(nucleus) reactions should exhibit geometric scaling on the single variable tau_A =Q2/Q2_{sat,A}. The dependence on energy and atomic number of the charged/neutral current cross sections are encoded in the saturation momentum Q_{sat,A}. This fact allows an analytical computation of the neutrino scattering on nucleon/nucleus at high energies, providing a theoretical parameterization based on the scaling property.Comment: 5 pages, 4 figure

Partial nutrient balances from agronomic and economic viewpoints: the case of corn cultivation in the acid upland soils of Isabela, the Philippines

Soil propertiesMaizeEconomic aspects

A New Sub-Period-Minimum Cataclysmic Variable With Partial Hydrogen Depletion And Evidence Of Spiral Disk Structure

We present time-resolved spectroscopy and photometry of CSS 120422:111127+571239 (=SBS 1108+574), a recently discovered SU UMa-type dwarf nova whose 55 minute orbital period is well below the cataclysmic variable (CV) period minimum of similar to 78 minutes. In contrast with most other known CVs, its spectrum features He I emission of comparable strength to the Balmer lines, implying a hydrogen abundance less than 0.1 of long-period CVs-but still at least 10 times higher than that in AM CVn stars. Together, the short orbital period and remarkable helium-to-hydrogen ratio suggest that mass transfer in CSS 120422 began near the end of the donor star's main-sequence lifetime, meaning that this CV is a strong candidate progenitor of an AM CVn system as described by Podsiadlowski et al. Moreover, a Doppler tomogram of the Ha line reveals two distinct regions of enhanced emission. While one is the result of the stream-disk impact, the other is probably attributable to spiral disk structure generated when material in the outer disk achieves a 2:1 orbital resonance with respect to the donor.NSF AST-1211196, AST-9987045Department of Physics at the University of Notre DameNSF Telescope System Instrumentation Program (TSIP)Ohio Board of RegentsOhio State University Office of ResearchAstronom

Intraventricular Thrombi with Systemic Embolization: Two Clinical Cases

A formação de trombos intraventriculares é um complicação frequente nos doentes com miocardiopatia dilatada e enfarte agudo do miocárdio, sendo o risco de embolização sistémica muito variável em função da patologia subjacente e características subjacentes dos trombos. Os autores descrevem dois casos clínicos relativos a dois doentes internados no mesmo dia com trombos intraventriculares, volumosos, protuberantes e muito móveis, no contexto de miocardiopatia dilatada e enfarte agudo do miocárdio, que embolizaram para os membros inferiores. Salientam a importância da ecocardiografia no diagnóstico, caracterização morfológica inicial e controlo evolutivo dos trombos intraventriculares, aspectos fundamentais na avaliação do risco embólico. Na ausência de recomendações específicas quanto às opções terapêuticas – anticoagulação, trombólise ou remoção cirúrgica, os autores sublinham a necessidade de avaliação individualizada, «caso a caso», tendo em conta o risco embólico, hemorrágico, e cirúrgico

Magnetotunneling Between Two-dimensional Electron Gases in InAs-AlSb-GaSb Heterostructures

We have observed that the tunneling magnetoconductance between two-dimensional (2D) electron gases formed at nominally identical InAs-AlSb interfaces most often exhibits two sets of Shubnikov-de Haas oscillations with almost the same frequency. This result is explained quantitatively with a model of the conductance in which the 2D gases have different densities and can tunnel between Landau levels with different quantum indices. When the epitaxial growth conditions of the interfaces are optimized, the zero-bias magnetoconductance shows a single set of oscillations, thus proving that the asymmetry between the two electron gases can be eliminated.Comment: RevTeX format including 4 figures; submit for publicatio

StemMapper: a curated gene expression database for stem cell lineage analysis.

Transcriptomic data have become a fundamental resource for stem cell (SC) biologists as well as for a wider research audience studying SC-related processes such as aging, embryonic development and prevalent diseases including cancer, diabetes and neurodegenerative diseases. Access and analysis of the growing amount of freely available transcriptomics datasets for SCs, however, are not trivial tasks. Here, we present StemMapper, a manually curated gene expression database and comprehensive resource for SC research, built on integrated data for different lineages of human and mouse SCs. It is based on careful selection, standardized processing and stringent quality control of relevant transcriptomics datasets to minimize artefacts, and includes currently over 960 transcriptomes covering a broad range of SC types. Each of the integrated datasets was individually inspected and manually curated. StemMapper's user-friendly interface enables fast querying, comparison, and interactive visualization of quality-controlled SC gene expression data in a comprehensive manner. A proof-of-principle analysis discovering novel putative astrocyte/neural SC lineage markers exemplifies the utility of the integrated data resource. We believe that StemMapper can open the way for new insights and advances in SC research by greatly simplifying the access and analysis of SC transcriptomic data. StemMapper is freely accessible at http://stemmapper.sysbiolab.eu

Ultrahigh energy neutrinos and non-linear QCD dynamics

The ultrahigh energy neutrino-nucleon cross sections are computed taking into account different phenomenological implementations of the non-linear QCD dynamic s. Based on the color dipole framework, the results for the saturation model supplemented by DGLAP evolution as well as for the BFKL formalism in the geometric scaling regime are presented. They are contrasted with recent calculations using NLO DGLAP and unified BFKL-DGLAP formalisms.Comment: 5 pages, 2 figures. Version to be published in Physical Review

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited efficacy in patients with medulloblastoma, due to compensatory mechanisms that maintain an active HH‑GLI signaling status. Thus, the identification of novel actionable mechanisms, directly affecting the activity of the HH‑regulated GLI transcription factors is an important goal for these malignancies. In this study, using gene expression and reporter assays, combined with biochemical and cellular analyses, we demonstrate that mitogen‑activated kinase kinase kinase 1 (MEKK1), the most upstream kinase of the mitogen‑activated protein kinase (MAPK) phosphorylation modules, suppresses HH signaling by associating and phosphorylating GLI1, the most potent HH‑regulated transcription factor. Phosphorylation occurred at multiple residues in the C‑terminal region of GLI1 and was followed by an increased association with the cytoplasmic proteins 14‑3‑3. Of note, the enforced expression of MEKK1 or the exposure of medulloblastoma cells to the MEKK1 activator, Nocodazole, resulted in a marked inhibitory effect on GLI1 activity and tumor cell proliferation and viability. Taken together, the results of this study shed light on a novel regulatory mechanism of HH signaling, with potentially relevant implications in cancer therapy