The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

Tumors comprise functionally diverse subpopulations of cells with distinct proliferative potential. Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with tumor differentiation status, patient survival, and, at the single-cell level, cancer stem cell markers. Silencing of H1.0 promotes maintenance of self-renewing cells by inducing derepression of megabase-sized gene domains harboring downstream effectors of oncogenic pathways. Self-renewing epigenetic states are not stable, and reexpression of H1.0 in subsets of tumor cells establishes transcriptional programs that restrict cancer cells’ long-term proliferative potential and drive their differentiation. Our results uncover epigenetic determinants of tumor-maintaining cells

Dicyclic Horizontal Symmetry and Supersymmetric Grand Unification

It is shown how to use as horizontal symmetry the dicyclic group $Q_6 \subset SU(2)$ in a supersymmetric unification $SU(5)\otimes SU(5)\otimes SU(2)$ where one $SU(5)$ acts on the first and second families, in a horizontal doublet, and the other acts on the third. This can lead to acceptable quark masses and mixings, with an economic choice of matter supermultiplets, and charged lepton masses can be accommodated.Comment: 10 pages, LaTe

Bilinear R-parity violation with flavor symmetry

Bilinear R-parity violation (BRPV) provides the simplest intrinsically supersymmetric neutrino mass generation scheme. While neutrino mixing parameters can be probed in high energy accelerators, they are unfortunately not predicted by the theory. Here we propose a model based on the discrete flavor symmetry $A_4$ with a single R-parity violating parameter, leading to (i) correct Cabbibo mixing given by the Gatto-Sartori-Tonin formula, and a successful unification-like b-tau mass relation, and (ii) a correlation between the lepton mixing angles $\theta_{13}$ and $\theta_{23}$ in agreement with recent neutrino oscillation data, as well as a (nearly) massless neutrino, leading to absence of neutrinoless double beta decay.Comment: 16 pages, 3 figures. Extended version, as published in JHE

Fermion Electric Dipole Moments in Supersymmetric Models with R-parity Violation

We analyze the electron and neutron electric dipole moments induced by R-parity violating interactions in supersymmetric models. It is pointed out that dominant contributions can come from one-loop diagrams involving both the bilinear and trilinear R-parity odd couplings, leading to somewhat severe constraints on the products of those couplings.Comment: Revtex, 19pp, four figures in axodraw.st

A Supersymmetric Theory of Flavor and R Parity

We construct a renormalizable, supersymmetric theory of flavor and $R$ parity based on the discrete flavor group $(S_3)^3$. The model can account for all the masses and mixing angles of the Standard Model, while maintaining sufficient squark degeneracy to circumvent the supersymmetric flavor problem. By starting with a simpler set of flavor symmetry breaking fields than we have suggested previously, we construct an economical Froggatt-Nielsen sector that generates the desired elements of the fermion Yukawa matrices. With the particle content above the flavor scale completely specified, we show that all renormalizable $R$-parity-violating interactions involving the ordinary matter fields are forbidden by the flavor symmetry. Thus, $R$ parity arises as an accidental symmetry in our model. Planck-suppressed operators that violate $R$ parity, if present, can be rendered harmless by taking the flavor scale to be $\lesssim 8 \times 10^{10}$ GeV.Comment: 28 pp. LaTeX, 1 Postscript Figur

REALISTIC MODELS WITH A LIGHT U(1) GAUGE BOSON COUPLED TO BARYON NUMBER

We recently showed that a new gauge boson $\gamma_B$ coupling only to baryon number is phenomenologically allowed, even if $m_B<m_Z$ and $\alpha_B \approx 0.2$. In our previous work we assumed that kinetic mixing between the baryon number and hypercharge gauge bosons (via an $F^{\mu\nu}_B F_{\mu\nu}^Y$ term) was small enough to evade constraints from precision electroweak measurements. In this paper we propose a class of models in which this term is naturally absent above the electroweak scale. We show that the generation of a mixing term through radiative corrections in the low-energy effective theory does not lead to conflict with precision electroweak measurements and may provide a leptonic signal for models of this type at an upgraded Tevatron.Comment: 21 pages, LaTeX, 4 figures in a uuencoded compressed postscript file

Supersymmetric Froggatt-Nielsen Models with Baryon- and Lepton-Number Violation

We systematically investigate the embedding of U(1)_X Froggatt-Nielsen models in (four-dimensional) local supersymmetry. We restrict ourselves to models with a single flavon field. We do not impose a discrete symmetry by hand, e.g. R-parity, baryon-parity or lepton-parity. Thus we determine the order of magnitude of the baryon- and/or lepton violating coupling constants through the Froggatt-Nielsen mechanism. We then scrutinize whether the predicted coupling constants are in accord with weak or GUT scale constraints. Many models turn out to be incompatible.Comment: Final version, references added, minor corrections; LaTeX, 46 page

Supersymmetry without R-Parity and without Lepton Number

We investigate Supersymmetric models where neither R parity nor lepton number is imposed. Neutrino masses can be kept highly suppressed compared to the electroweak scale if the $\mu$-terms in the superpotential are aligned with the SUSY-breaking bilinear $B$-terms. This situation arises naturally in the framework of horizontal symmetries. The same symmetries suppress the trilinear R parity violating terms in the superpotential to an acceptable level.Comment: 18 pages, harvma