Asymptotic Frequency Distributions for Variable Coefficients Rayleigh Beams under Boundary Feedback Control

The analysis of the boundary damping rate for eigenmodes of a Rayleigh Beam with variable coefficients is usually difficult because explicit solution formula are hard to come by. In this paper, by using the estimating devices of [9], we can carry out an asymptotic analysis and conclude that there is a uniform damping rate for the high frequency modes. As a result, Riesz basis property and exponential stability can be deduced and a conjecture in [3] is settled.published_or_final_versio

Partitioning of Phenylalanine Ammonia-lyase from Rhodotorula glutinis in Aqueous Two-phase Systems of PEG/salts

In this work, the partitioning of phenylalanine ammonia-lyase was investigated in different systems of PEG1000, PEG2000, PEG3350, PEG6000 and PEG8000 with (NH4)2SO4, Na2SO4, Na2CO3 and potassium phosphate. The results showed that the partition of phenylalanine ammonia-lyase in PEG/salt aqueous two-phase systems was mainly influenced by hydrophobicity, excluded volume effect and salting-out effect; compared with other PEG/salt systems, PEG1000/Na2SO4 was the most effective for phenylalanine ammonia-lyase partitioning. The result further supports that PEG/salt aqueous two-phase system provides a new and applicable route for the purification of phenylalanine ammonia-lyase, as shown in our published paper.1

The new advances in sulforaphen

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The effect of mycelial morphology on lycopene fermentaton

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Bone Sialoprotein Gene Transfer to Periodontal Ligament Cells May Not Be Sufficient to Promote Mineralization In Vitro or In Vivo

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141649/1/jper0167.pd

A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road

Contemporary Jews retain a genetic imprint from their Near Eastern ancestry, but obtained substantial genetic components from their neighboring populations during their history. Whether they received any genetic contribution from the Far East remains unknown, but frequent communication with the Chinese has been observed since the Silk Road period. To address this issue, mitochondrial DNA (mtDNA) variation from 55,595 Eurasians are analyzed. The existence of some eastern Eurasian haplotypes in eastern Ashkenazi Jews supports an East Asian genetic contribution, likely from Chinese. Further evidence indicates that this connection can be attributed to a gene flow event that occurred less than 1.4 kilo-years ago (kya), which falls within the time frame of the Silk Road scenario and fits well with historical records and archaeological discoveries. This observed genetic contribution from Chinese to Ashkenazi Jews demonstrates that the historical exchange between Ashkenazim and the Far East was not confined to the cultural sphere but also extended to an exchange of genes

Promoting Construction Industrialisation with Policy Interventions: A Holistic Review of Published Policy Literature.

By adopting the concept of 'factory assembly followed by onsite installation,' construction industrialisation (CI) plays an increasingly important role in sustainable urban development. CI can enhance construction quality and efficiency while reducing environmental impacts. To promote the CI, several policy interventions have been developed and implemented in different countries and regions. This study reviews the global CI promoting regulations and policies to provide a comprehensive insight into its interrelationship and development tendency. The research selects 105 publications related to practical CI policy from widely utilised databases (i.e., Web of Science and Scopus). Based on the annual publication trend analysis, geospatial distribution, and citation analysis, seven interrelated critical CI policy formulation themes are identified and examined: regulatory policies, standardised policies, promotional policies, urban design and planning policies, technological policies, managerial and educational policies, and sustainability policies. In addition, internal correlations and mutual influence among these seven classified policies are explored and discussed, which helps scholars enhance their grasp of current CI policy research and guide future research. This review provides the research community and industrial practitioners with a comprehensive understanding of various CI-promoting policies and a roadmap to CI-promoting policy development and evaluation

Dynamic tubulation of mitochondria drives mitochondrial network formation

© 2015 IBCB, SIBS, CAS. Mitochondria form networks. Formation of mitochondrial networks is important for maintaining mitochondrial DNA integrity and interchanging mitochondrial material, whereas disruption of the mitochondrial network affects mitochondrial functions. According to the current view, mitochondrial networks are formed by fusion of individual mitochondria. Here, we report a new mechanism for formation of mitochondrial networks through KIF5B-mediated dynamic tubulation of mitochondria. We found that KIF5B pulls thin, highly dynamic tubules out of mitochondria. Fusion of these dynamic tubules, which is mediated by mitofusins, gives rise to the mitochondrial network. We further demonstrated that dynamic tubulation and fusion is sufficient for mitochondrial network formation, by reconstituting mitochondrial networks in vitro using purified fusion-competent mitochondria, recombinant KIF5B, and polymerized microtubules. Interestingly, KIF5B only controls network formation in the peripheral zone of the cell, indicating that the mitochondrial network is divided into subzones, which may be constructed by different mechanisms. Our data not only uncover an essential mechanism for mitochondrial network formation, but also reveal that different parts of the mitochondrial network are formed by different mechanisms

Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency

Background Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication stress. Although various genetic and epigenetic signatures have been linked to the replication efficiency of origins, there is no consensus on how the selection of origins is determined. Results We apply dual-color stochastic optical reconstruction microscopy (STORM) super-resolution imaging to map the spatial distribution of origins within individual topologically associating domains (TADs). We find that multiple replication origins initiate separately at the spatial boundary of a TAD at the beginning of the S phase. Intriguingly, while both high-efficiency and low-efficiency origins are distributed homogeneously in the TAD during the G1 phase, high-efficiency origins relocate to the TAD periphery before the S phase. Origin relocalization is dependent on both transcription and CTCF-mediated chromatin structure. Further, we observe that the replication machinery protein PCNA forms immobile clusters around TADs at the G1/S transition, explaining why origins at the TAD periphery are preferentially fired. Conclusion Our work reveals a new origin selection mechanism that the replication efficiency of origins is determined by their physical distribution in the chromatin domain, which undergoes a transcription-dependent structural re-organization process. Our model explains the complex links between replication origin efficiency and many genetic and epigenetic signatures that mark active transcription. The coordination between DNA replication, transcription, and chromatin organization inside individual TADs also provides new insights into the biological functions of sub-domain chromatin structural dynamics