151 research outputs found
Density Fluctuations in an Electrolyte from Generalized Debye-Hueckel Theory
Near-critical thermodynamics in the hard-sphere (1,1) electrolyte is well
described, at a classical level, by Debye-Hueckel (DH) theory with (+,-) ion
pairing and dipolar-pair-ionic-fluid coupling. But DH-based theories do not
address density fluctuations. Here density correlations are obtained by
functional differentiation of DH theory generalized to {\it non}-uniform
densities of various species. The correlation length diverges universally
at low density as (correcting GMSA theory). When
one has as
where the amplitudes compare informatively with experimental data.Comment: 5 pages, REVTeX, 1 ps figure included with epsf. Minor changes,
references added. Accepted for publication in Phys. Rev. Let
Features of the citrullinating peptidylarginine deiminase enzymes
Contains fulltext :
58471.pdf (publisher's version ) (Open Access
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presence is predictive for disease development. However, the functional consequences of VDGs on autoreactive B cells remain elusive. Combining crystallography, glycobiology, and functional B cell assays allowed us to dissect key characteristics of VDGs on human B cell biology. Crystal structures showed that VDGs are positioned in the vicinity of the antigen-binding pocket, and dynamic modeling combined with binding assays elucidated their impact on binding. We found that VDG-expressing B cell receptors stay longer on the B cell surface and that VDGs enhance B cell activation. These results provide a rationale on how the acquisition of VDGs might contribute to the breach of tolerance of autoreactive B cells in a major human autoimmune disease.Medicinal Chemistr
Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits
Contains fulltext :
150338.pdf (publisher's version ) (Open Access)5 p
Ribonucleoprotein complexes as autoantigens
Contains fulltext :
28701.pdf (publisher's version ) (Open Access
LINE-1 Hypermethylation in serum cell-free DNA of relapsing remitting multiple sclerosis patients
Contains fulltext :
177153.pdf (publisher's version ) (Open Access)8 p
RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences
Contains fulltext :
150327.pdf (publisher's version ) (Open Access
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