44 research outputs found
MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell
Event Horizons in Numerical Relativity I: Methods and Tests
This is the first paper in a series on event horizons in numerical
relativity. In this paper we present methods for obtaining the location of an
event horizon in a numerically generated spacetime. The location of an event
horizon is determined based on two key ideas: (1) integrating backward in time,
and (2) integrating the whole horizon surface. The accuracy and efficiency of
the methods are examined with various sample spacetimes, including both
analytic (Schwarzschild and Kerr) and numerically generated black holes. The
numerically evolved spacetimes contain highly distorted black holes, rotating
black holes, and colliding black holes. In all cases studied, our methods can
find event horizons to within a very small fraction of a grid zone.Comment: 22 pages, LaTeX with RevTeX 3.0 macros, 20 uuencoded gz-compressed
postscript figures. Also available at http://jean-luc.ncsa.uiuc.edu/Papers/
Submitted to Physical Review
Gravitational Radiation from Rotational Instabilities in Compact Stellar Cores with Stiff Equations of State
We carry out 3-D numerical simulations of the dynamical instability in
rapidly rotating stars initially modeled as polytropes with n = 1.5, 1.0, and
0.5. The calculations are done with a SPH code using Newtonian gravity, and the
gravitational radiation is calculated in the quadrupole limit. All models
develop the global m=2 bar mode, with mass and angular momentum being shed from
the ends of the bar in two trailing spiral arms. The models then undergo
successive episodes of core recontraction and spiral arm ejection, with the
number of these episodes increasing as n decreases: this results in
longer-lived gravitational wave signals for stiffer models. This instability
may operate in a stellar core that has expended its nuclear fuel and is
prevented from further collapse due to centrifugal forces. The actual values of
the gravitational radiation amplitudes and frequencies depend sensitively on
the radius of the star R_{eq} at which the instability develops.Comment: 39 pages, uses Latex 2.09. To be published in the Dec. 15, 1996 issue
of Physical Review D. 21 figures (bitmapped). Originals available in
compressed Postscript format at ftp://zonker.drexel.edu/papers/bars
Finding Apparent Horizons in Dynamic 3D Numerical Spacetimes
We have developed a general method for finding apparent horizons in 3D
numerical relativity. Instead of solving for the partial differential equation
describing the location of the apparent horizons, we expand the closed 2D
surfaces in terms of symmetric trace--free tensors and solve for the expansion
coefficients using a minimization procedure. Our method is applied to a number
of different spacetimes, including numerically constructed spacetimes
containing highly distorted axisymmetric black holes in spherical coordinates,
and 3D rotating, and colliding black holes in Cartesian coordinates.Comment: 19 pages, 13 figures, LaTex, to appear in Phys. Rev. D. Minor changes
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Three dimensional numerical relativity: the evolution of black holes
We report on a new 3D numerical code designed to solve the Einstein equations
for general vacuum spacetimes. This code is based on the standard 3+1 approach
using cartesian coordinates. We discuss the numerical techniques used in
developing this code, and its performance on massively parallel and vector
supercomputers. As a test case, we present evolutions for the first 3D black
hole spacetimes. We identify a number of difficulties in evolving 3D black
holes and suggest approaches to overcome them. We show how special treatment of
the conformal factor can lead to more accurate evolution, and discuss
techniques we developed to handle black hole spacetimes in the absence of
symmetries. Many different slicing conditions are tested, including geodesic,
maximal, and various algebraic conditions on the lapse. With current
resolutions, limited by computer memory sizes, we show that with certain lapse
conditions we can evolve the black hole to about , where is the
black hole mass. Comparisons are made with results obtained by evolving
spherical initial black hole data sets with a 1D spherically symmetric code. We
also demonstrate that an ``apparent horizon locking shift'' can be used to
prevent the development of large gradients in the metric functions that result
from singularity avoiding time slicings. We compute the mass of the apparent
horizon in these spacetimes, and find that in many cases it can be conserved to
within about 5\% throughout the evolution with our techniques and current
resolution.Comment: 35 pages, LaTeX with RevTeX 3.0 macros. 27 postscript figures taking
7 MB of space, uuencoded and gz-compressed into a 2MB uufile. Also available
at http://jean-luc.ncsa.uiuc.edu/Papers/ and mpeg simulations at
http://jean-luc.ncsa.uiuc.edu/Movies/ Submitted to Physical Review
A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci
Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma (MM)