43 research outputs found

    Intervención terapéutica mediante el ocio y tiempo libre con personas con enfermedad mental

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    Mediante el presente trabajo se realiza una visualización del Ocio y tiempo libre, y la importancia del mismo para las personas que sufren de una enfermedad mental. Tras esta visualización se realiza un proyecto de ocio y tiempo libre con el que poder trabajar con personas con enfermedad mental, para así poder facilitar la integración de la persona en la sociedad, además del aprendizaje del uso de un ocio positivo

    El accidente del Yak-42. Análisis en la prensa de un caso de periodismo de investigación.

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    El periodismo de investigación ha sacado a la luz algunos de los casos más polémicos de la vida política española. Uno de ellos es del Yak-42, un accidente aéreo, ocurrido en 2003, en el que murieron 62 militares y cuyas causas todavía no son claras. El presente trabajo ha analizado la cobertura periodística que se desarrolló acerca del siniestro, entre el 26 de mayo y el 1 de junio de 2003. La investigación se sustenta sobre la teoría del Framing y se ha servido del análisis de contenido para conocer las diferencias y similitudes de la cobertura de cuatro diarios; dos regionales (Heraldo de Aragón y El Periódico de Aragón) y dos de ámbito nacional (El Mundo y El País). Así, se ha puesto el foco tanto en aspectos formales como de contenido con el objetivo de conocer las directrices de distintas coberturas periodísticas.<br /

    Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits

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    Local long-term delivery of glial cell line derived neurotrophic factor (GDNF) from vitamin E/poly-lactic-co-glycolic acid microspheres (MSs) protects retinal ganglion cells in an animal model of glaucoma for up to 11 weeks. However, the pharmacokinetics of GDNF after intravitreal injection of MSs is not known. We evaluated the GDNF levels after a single intravitreal injection of GDNF/VitE MSs. Biodegradable MSs were prepared by the solid-oil-in-water emulsion-solvent evaporation technique and characterized. Rabbits received a single intravitreal injection (50 μL) of GDNF/VitE MSs (4%w/v; 24 right eyes; 74.85 ng GDNF), blank MSs (4%w/v; 24 left eyes), and balanced salt solution (4 eyes). Two controls eyes received no injections. At 24 hours, 1, 4, 6, 8, 12, 18, and 24 weeks after injection, the eyes were enucleated, and the intravitreal GDNF levels were quantified. Pharmacokinetic data were analysed according to non-compartmental model. Intraocular GDNF levels of 717.1 ± 145.1 pg/mL were observed at 24 hours for GDNF-loaded MSs, followed by a plateau (745.3 ± 25.5 pg/mL) until day 28. After that, a second plateau (17.4 ± 3.7 pg/mL) occurred from 8 to 24 weeks postinjection, significantly higher than the basal levels. Eyes injected with GDNF/vitE and Blank-MSs did not show any abnormalities during the six-months follow up after administration. The single injection of GDNF/VitE MSs provided a sustained controlled release of the neurotrophic factor in a controlled fashion for up to six months

    Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits

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    Local long-term delivery of glial cell line derived neurotrophic factor (GDNF) from vitamin E/poly-lactic-co-glycolic acid microspheres (MSs) protects retinal ganglion cells in an animal model of glaucoma for up to 11 weeks. However, the pharmacokinetics of GDNF after intravitreal injection of MSs is not known. We evaluated the GDNF levels after a single intravitreal injection of GDNF/VitE MSs. Biodegradable MSs were prepared by the solid-oil-in-water emulsion-solvent evaporation technique and characterized. Rabbits received a single intravitreal injection (50 μL) of GDNF/VitE MSs (4%w/v; 24 right eyes; 74.85 ng GDNF), blank MSs (4%w/v; 24 left eyes), and balanced salt solution (4 eyes). Two controls eyes received no injections. At 24 hours, 1, 4, 6, 8, 12, 18, and 24 weeks after injection, the eyes were enucleated, and the intravitreal GDNF levels were quantified. Pharmacokinetic data were analysed according to non-compartmental model. Intraocular GDNF levels of 717.1 ± 145.1 pg/mL were observed at 24 hours for GDNF-loaded MSs, followed by a plateau (745.3 ± 25.5 pg/mL) until day 28. After that, a second plateau (17.4 ± 3.7 pg/mL) occurred from 8 to 24 weeks postinjection, significantly higher than the basal levels. Eyes injected with GDNF/vitE and Blank-MSs did not show any abnormalities during the six-months follow up after administration. The single injection of GDNF/VitE MSs provided a sustained controlled release of the neurotrophic factor in a controlled fashion for up to six months

    Experiencias subjetivas sobre las clases virtuales en universitarios peruanos en tiempos de COVID 19

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    La presente investigación es de corte cualitativo que tiene como objetivo conocer la percepción sobre la experiencia de recibir clases virtuales en universitarios peruanos, se realizó entrevistas semi-estructuradas a un grupo de jóvenes universitarios, cuyas edades oscilan entre los años 18 a 40 años de edad de diversos niveles económicos y culturales

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

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    Notas Breves

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