Local party members’ views are associated, but not completely congruent, with local constituency opinion

Do local political party members reflect the views of voters in their constituencies? Since candidate selection by local party members is the most common form of candidate selection in the United Kingdom, it is important to understand local party members’ views, and how those views relate to views in the local area. We investigate the degree to which individual members’ views match local opinion by combining the results of a large-scale survey of party members in the United Kingdom with estimates of local opinion created using multilevel regression and post-stratification. We find that individual party members’ views are moderately to strongly associated with local opinion on both left-right and liberty-authority dimensions. Even so, party members are not entirely congruent with opinion in the local area, having opinions which are either to the left or right of voters in their local area, and which are uniformly more liberal than party supporters

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling.

One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment. However, these deep tissue imaging techniques have not yet been adopted to investigate the second messenger calcium (Ca2+). In the present study, we established conditions that allow the in vivo detection of Ca2+ signaling in three-dimensional tumor masses in mouse models. By combining intravital imaging and a skinfold chamber technique, we determined the ability of photodynamic cancer therapy to induce an increase in intracellular Ca2+ concentrations and, consequently, an increase in cell death in a p53-dependent pathway

Interaction-induced impeding of decoherence and anomalous diffusion

We study how the interplay of dissipation and interactions affects the dynamics of a bosonic many-body quantum system. In the presence of both dissipation and strongly repulsive interactions, observables such as the coherence and the compressibility display three dynamical regimes: an initial exponential variation followed by a power-law regime and finally a slow exponential convergence to their asymptotic values corresponding to the infinite temperature state. These very long-time scales arise as dissipation forces the population of states disfavored by interactions. The long-time, strong coupling dynamics are understood by performing a mapping onto a classical diffusion process displaying non-Brownian behavior. While both dissipation and strong interactions tend to suppress coherence when acting separately, we find that strong interaction impedes the decoherence process generated by the dissipation.Comment: 5 pages, 3 figure

New hairy black hole solutions with a dilaton potential

We consider black hole solutions with a dilaton field possessing a nontrivial potential approaching a constant negative value at infinity. The asymptotic behaviour of the dilaton field is assumed to be slower than that of a localized distribution of matter. A nonabelian SU(2) gauge field is also included in the total action. The mass of the solutions admitting a power series expansion in $1/r$ at infinity and preserving the asymptotic anti-de Sitter geometry is computed by using a counterterm subtraction method. Numerical arguments are presented for the existence of hairy black hole solutions for a dilaton potential of the form $V(\phi)=C_1 \exp(2\alpha_1 \phi)+C_2 \exp(2\alpha_2 \phi)+C_3$, special attention being paid to the case of ${\cal N}=4, D=4$ gauged supergravity model of Gates and Zwiebach.Comment: 12 pages, 4 figures; v2:references added, typos corrected, small changes in Section

The transbonchial lung biopsy for diagnosis of diffuse parenchymal lung disease; Pro

The diagnosis of diffuse parenchymal lung disease (DPLD) may require invasive procedures after all noninvasive tools have failed. The clinical context in which these diseases develop and the radiological patterns are crucial for defining the timing and the methods to be used. After the introduction in clinical practice of HRCT scan, the evaluation of imaging patterns, along with the immunological status of the patient and the clinical course of the disease (acute vs. chronic) seem to be crucial to choose the best diagnostic procedure

Observation of gain-pinned dissipative solitons in a microcavity laser

This work was supported by the National Science Center in Poland, by Grant Nos. 2016/23/N/ST3/01350 and 2018/30/E/ST7/00648, and by the Polish National Agency for Academic Exchange. The Würzburg group gratefully acknowledges support by the State of Bavaria. The work at the Australian National University was supported by the Australian Research Council.We demonstrate an experimental approach for creating spatially localized states in a semiconductor microcavity laser. In particular, we shape the spatial gain profile of a quasi-one-dimensional microcavity laser with a nonresonant, pulsed optical pump to create spatially localized structures, known as gain-pinned dissipative solitons, that exist due to the balance of gain and nonlinear losses. We directly probe the ultrafast formation dynamics and decay of these localized structures, showing that they are created on a picosecond timescale, orders of magnitude faster than laser cavity solitons. All of the experimentally observed features and dynamics are reconstructed by numerical modeling using a complex Ginzburg-Landau model, which explicitly takes into account the carrier density dynamics in the semiconductor.Publisher PDFPeer reviewe

Synthesis of stabilized analogues of fragments of Neisseria meningitidis type A capsular polysaccharide

The resistance to Neisseria meningitidis (N. m.), a gram-negative bacterium causing meningitis, is mediated by the presence of antibodies directed against its capsular polysaccharides (CPS), which are associated with different serogroups. One of the most virulent is serotype A (Men A), whose CPS is constituted of (\uf0ae6)-N-acetylmannosamine \uf061-1-O-Phosphate as a repeating unit. The already existing vaccines against N.m. give a T-cell independent immune response, therefore inefficient in infants. The response can be improved by conjugation of the saccharidic portion to a protein carrier, which invokes T-cell involvement. In addition, anomeric phosphodiester bridges are chemically labile and therefore not appropriate for a vaccine. To overcome these problems, phosphonate 4 and its oligomers 5 and 7 have been synthesised as stable analogues of the repeating unit of Men A CPS. Key steps of the synthetic strategy are: a) Synthesis of building blocks 3 and 4, the latter bearing a spacer at the reducing end suitable for conjugation to a proper protein carrier; b) Coupling of 3 with 4 via Mitsunobu reaction providing 5, followed by 6'-O-deacetylation and a second Mitsunobu coupling to give trimer 7. After removal of the protecting groups, the synthesized compounds have been evaluated through a competitive ELISA assay (IC50 values) by use of Men A antiserum. Moreover, preliminary approaches towards the carba-analogue 8 of N-acetylmannosamine 1-O-phosphate, a key building block for the synthesis of a new type of Men A analogues, will be also discussed

iCanCloud: a flexible and scalable cloud infrastructure simulator

Simulation techniques have become a powerful tool for deciding the best starting conditions on pay-as-you-go scenarios. This is the case of public cloud infrastructures, where a given number and type of virtual machines (in short VMs) are instantiated during a specified time, being this reflected in the final budget. With this in mind, this paper introduces and validates iCanCloud, a novel simulator of cloud infrastructures with remarkable features such as flexibility, scalability, performance and usability. Furthermore, the iCanCloud simulator has been built on the following design principles: (1) it's targeted to conduct large experiments, as opposed to others simulators from literature; (2) it provides a flexible and fully customizable global hypervisor for integrating any cloud brokering policy; (3) it reproduces the instance types provided by a given cloud infrastructure; and finally, (4) it contains a user-friendly GUI for configuring and launching simulations, that goes from a single VM to large cloud computing systems composed of thousands of machines.This research was partially supported by the following projects: Spanish MEC project TESIS (TIN2009-14312-C02-01), and Spanish Ministry of Science and Innovation under the grant TIN2010-16497.Publicad

Charged Dilatonic AdS Black Branes in Arbitrary Dimensions

We study electromagnetically charged dilatonic black brane solutions in arbitrary dimensions with flat transverse spaces, that are asymptotically AdS. This class of solutions includes spacetimes which possess a bulk region where the metric is approximately invariant under Lifshitz scalings. Given fixed asymptotic boundary conditions, we analyze how the behavior of the bulk up to the horizon varies with the charges and derive the extremality conditions for these spacetimes.Comment: References update