Marcin Gadocha, Urzędnicy miejscy Biecza do 1772 roku. Spisy urzędników miejskich z obszaru dawnej Rzeczpospolitej, Śląska i Pomorza Zachodniego, t. 3: Małopolska, z. 6: Biecz, Polskie Towarzystwo Historyczne, Białystok 2020, ss. 227.

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Empirical modeling of the sodium channel inhibition caused by drugs

The aim of this work was to create extended QSAR model of the relationship between sodium channel blocking activity of the particular compound and its chemical structure together with the in vitro assay conditions. Artificial neural networks (ANNs) were chosen as modeling tools. Chemoinformatics software was used for calculation of the molecular descriptors describing the structure of the interest. Drug concentration causing 50% of the channel inhibition (IC50) was used as the modeling endpoint. The data was based on the literature search and consisted of 38 drugs and 108 records. Initial number of inputs was 110 and during the sensitivity analysis was reduced to 20. ANNs models were optimized in the extended 10-fold cross-validation scheme yielding RMSE = 0.68, NRMSE = 20.7% and R2= 0.35. Best models were ANNs ensembles combining three ANNs with their outputs averaged as a collective output of the system

Cardiovascular risk assessment, cardiovascular disease risk factors, and lung function parameters

Background: Decreased lung function is related to higher cardiovascular disease (CVD) incidence and mortality. However, little is known about the relationship between the risk factors of CVD and pulmonary function. Aim: The aim of the study was to assess the relationship between the prevalence of cardiovascular risk factors, the total CVD risk, and pulmonary function. Methods: The analysis included 4104 men and women aged 45 to 69 years, participants of the Polish part of the Health, Alcohol, and Psychosocial factors In Eastern Europe (HAPIEE) Project, who provided valid measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) using a Micro-Medical Microplus spirometer. The prevalence of CVD risk factors was defined as follows: hypertension (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or taking hypertension medication), diabetes (glucose ≥ 7.1 mmol/L or self-reported diabetes), and hypercholesterolaemia (total cholesterol ≥ 5 mmol/L or low-density lipoprotein-cholesterol ≥ 3 mmol/L or taking lipid lowering medication). Categories of total CVD risk were defined according to the 2016 European Guidelines on CVD prevention in clinical practice. The analysis of covariance was used to compare the lung function in the CVD risk factors and the total CVD risk categories. Results: Mean values of FEV1 and FVC, adjusted for age and height, were significantly higher in men than in women (3.02 L; 95% confidence interval [CI] 2.96–3.08 L vs. 2.52 L; 95% CI 2.45–2.63 L for FEV1 and 3.62 L; 95% CI 3.56–3.69 L vs. 3.05 L; 95% CI 2.98–3.12 L for FVC). Obesity was significantly associated with FVC in men and women; it was associated with FEV1 only in men. Compared with participants with normal body mass index, obese men and women had 280 mL and 112 mL lower mean FVC, respectively. Men without hypertension had almost 100 mL higher mean FVC than those with hypertension. The difference in FVC in women was approximately 80 mL. Diabetes was associated with lower values of FVC in both sexes and with FEV1 in women. A significant negative trend was observed in the mean FVC and FEV1 by the considered CVD risk categories. Conclusions: Impaired lung function was associated with higher CVD risk, which could be explained partly by an adverse association between lung function and prevalence of obesity, hypertension, and diabetes.Wstęp: Upośledzenie funkcji oddechowych  jest związane z wyższym ryzykiem zachorowania i zgonu  z powodu chorób  sercowo-naczyniowych (ChSN). Jednak  wiedza dotycząca związku pomiędzy czynnikami ryzyka ChSN oraz ogólną oceną ryzyka sercowo-naczyniowego, a funkcjami oddechowymi nie jest pełna. Cel: Oszacowanie związku pomiędzy występowaniem czynników ryzyka ChSN oraz  całkowitym ryzykiem sercowo-naczyniowym a funkcjami oddechowymi. Metody: Do analizy zakwalifikowano 4104 mężczyzn i kobiet w wieku pomiędzy 45 a 69 lat, uczestników polskiej części badania HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe), dla których uzyskano wiarygodne pomiary natężonej pojemności życiowej płuc (FVC) oraz  natężonej objętości wydechowej pierwszo-sekundowej (FEV1) przy użyciu aparatu Micro-Medical Microplus. Przyjęto następujące definicje czynników ryzyka: nadciśnienie tętnicze (SBP≥140 [mmHg] lub DBP≥90 [mmHg] lub przyjmowanie leków hipotensyjnych), cukrzyca (glukoza≥7,1[mmol/l] lub cukrzyca rozpoznana przez lekarza), hipercholesterolemia (cholesterol całkowity≥5 [mmol/l]  lub LDL-cholesterol≥3 [mmol/l] lub przyjmowanie leków hipolipemizujących). Kategorie całkowitego ryzyka sercowo-naczyniowego  zostały określone w oparciu o wytyczne ESC dotyczące prewencji chorób układu sercowo-naczyniowego w praktyce klinicznej w 2016 roku.. Do porównania funkcji oddechowych w kategoriach narażenia na czynniki ryzyka ChSN zastosowana została analiza kowariancji. Wyniki: Średnie wartości FEV1 oraz FVC standaryzowane do wieku oraz wzrostu były istotnie wyższe u mężczyzn w porównaniu do kobiet i wynosiły odpowiednio FEV1:3.02 L; 95% CI = 2,96–3,08 L vs. 2,52 L; 95% CI = 2,45–2,63 L;  FVC: 3,62 L: 95% CI= 3,56-3,69 L  vs.  3,05L; 95% CI= 2,98-3,12 L). Otyłość była istotnie związana z FVC u kobiet i mężczyzn, natomiast z FEV1 tylko u kobiet. W porównaniu do badanych o pożądanej masie ciała (BMI=20-25), otyli mężczyźni i kobiety (BMI>30) mieli niższe wartości FVC odpowiednio o 280 ml i 122 ml. Nadciśnienie tętnicze było istotnie związane z FEV1 i FVC. Mężczyźni z nadciśnieniem mieli o 100 ml niższe FVC w porównaniu do mężczyzn bez nadciśnienia. U kobiet różnica ta była mniejsza i wynosiła 80 ml. Występowanie cukrzycy było istotnie związane z niższymi wartościami  FVC u mężczyzn i u kobiet, natomiast z FEV1 tylko u kobiet. Nie zaobserwowano istotnego związku pomiędzy hipercholesterolemią a FEV1 i FVC. Zaobserwowano istotny ujemny trend w średnich wartościach FEV1 i FVC pomiędzy kategoriami całkowitego ryzyka sercowo-naczyniowego. Wniosek: Upośledzenie funkcji oddechowych  było związane z wyższym ryzykiem sercowo-naczyniowym, co częściowo może być wyjaśnione odwrotnym związkiem pomiędzy obniżonymi funkcjami  oddechowymi a występowaniem otyłości, nadciśnienia tętniczego  i cukrzycy.

Time-varying group delay as a basis for clustering and segmentation of seismic signals

In this paper the applications of group delay in seismic vibration signals analysis are discussed. A method which bases on the autoregressive model with sliding-window is used to track volatility of signal’s properties in time. The analysis of time-frequency maps of group delay can be used in a process of distinguishing signals of different characteristics. Moreover, the method is robust for the different parameters of the sliding-window AR model. In the article applications of the time-frequency maps of group delay in a signal segmentation and clustering are also discussed. In seismic analysis an ability to distinguish signals with different seismic nature is very important, especially in case of safety in copper-ore underground mines. Creation of tools for revealing the origin of vibration will have positive impact on evaluation of hazard level

A multidimensional questionnaire to measure career satisfaction of physicians : validation of the Polish version of the 4CornerSAT

To study physicians’ satisfaction with a multidimensional approach, the 4CornerSAT questionnaire to measure the career satisfaction of physicians was conceptualized in English and later adapted into Polish. In this study, we aimed to test the reliability and validity of the adapted 4CornerSAT questionnaire in Poland and confirm its the tetra-dimensional structure. In 2018, physicians working in 15 Polish hospitals were invited to participate in a survey that included the Polish 4CornerSAT. We evaluated the questionnaire’s reliability by computing Cronbach’s alpha coefficients. We also computed a Pearson correlation coefficient between the reported global item of satisfaction and the standardized level of career satisfaction. A confirmatory factorial analysis (CFA) tested the tetra-dimensional structure of the questionnaire in Polish. In total, 1003 physicians participated in this study. The questionnaire’s internal consistency and concurrent validity were optimal. In the CFA, good model fit indicators were observed. In conclusion, the Polish version of the 4CornerSAT demonstrated good psychometric properties. The adapted questionnaire has evidence of its validity and reliability in Poland to be used in further studies and to monitor physicians’ wellness as a health care system indicator. Our approach to adapt and validate this questionnaire could be replicated in other settings