25 research outputs found
See Me, Hear Me, Coach Me
The writers describe the implementation of virtual coaching for teachers in Alabama and Pennsylvania. They describe use of bug-in-ear devices, revolutionized by Internet and mobile technology advances, to provide on-the-spot feedback as teachers deliver instruction. They outline lessons learned from virtual coaching initiatives and present research results showing the positive impact of this approach on both teachers and students. They also provide advice for those using this approach on making contact and providing feedback
Hemicolectomy With Concomitant Heated Intraperitoneal Chemotherapy: A Case Study
The use of heated intraperitoneal chemotherapy is an emerging new adjunct in the treatment of adenocarcinoma of the colon. However, documentation regarding perfusion circuitry and techniques associated with this therapy remain largely undescribed. After consultation with the surgical service team, a custom designed circuit was constructed for this procedure. Institutional approval and informed consent were obtained for surgical debulking and heated intraperitoneal chemotherapy for a 58-year old female. After surgical resection, a right hemicolectomy was performed and pathological specimens obtained. A modified custom circuit using a roller pump was first primed with 3 liters of Dianeal® PD-2 and recirculated until temperature of 41°C was obtained. The circuit was then connected to the patient for infusion of perfusate via Blake drains placed in the deep pelvis. Two additional drains were placed in the subdiaphragmatic space for return. Perfusate containing 30 mg of Mitomycin-C was circulated at 600–800 mL/min for 60 min at 41°C. An additional 10 mg of Mitomycin-C was then administered through the circuit for an additional hour under similar conditions. Upon completion, a washout procedure was performed with 2 additional liters of Dianeal® PD-2. The patient tolerated the procedure well and was discharged postoperative day 7. We describe the successful use of a perfusion-administered heated intraperitoneal chemotherapy regimen as an integral part of successful treatment of adenocarcinoma of the colon
In vivo non-invasive imaging of gene transfer with single-photon emission computerized tomography
Multidentate <sup>18</sup>F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA)
β-Amyloid plaques (Aβ plaques) in the brain
are associated
with cerebral amyloid angiopathy (CAA). Imaging agents that could
target the Aβ plaques in the living human brain would be potentially
valuable as biomarkers in patients with CAA. A new series of <sup>18</sup>F styrylpyridine derivatives with high molecular weights
for selectively targeting Aβ plaques in the blood vessels of
the brain but excluded from the brain parenchyma is reported. The
styrylpyridine derivatives, <b>8a</b>–<b>c</b>,
display high binding affinities and specificity to Aβ plaques
(<i>K</i><sub>i</sub> = 2.87, 3.24, and 7.71 nM, respectively).
In vitro autoradiography of [<sup>18</sup>F]<b>8a</b> shows
labeling of β-amyloid plaques associated with blood vessel walls
in human brain sections of subjects with CAA and also in the tissue
of AD brain sections. The results suggest that [<sup>18</sup>F]<b>8a</b> may be a useful PET imaging agent for selectively detecting
Aβ plaques associated with cerebral vessels in the living human
brain