Interactions among myeloid regulatory cells in cancer

Mounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune reaction to cancer. Myeloid cells are a major component of host cells infiltrating tumors, interacting with each other, with tumor cells and other stromal cells, and demonstrating a prominent plasticity. We describe here various myeloid regulatory cells (MRCs) in mice and human as well as their relevant therapeutic targets. We first address the role of the monocytes and macrophages that can contribute to angiogenesis, immunosuppression and metastatic dissemination. Next, we discuss the differential role of neutrophil subsets in tumor development, enhancing the dual and sometimes contradicting role of these cells. A heterogeneous population of immature myeloid cells, MDSCs, was shown to be generated and accumulated during tumor progression as well as to be an important player in cancer-related immune suppression. Lastly, we discuss the role of myeloid DCs, which can either contribute to effective anti-tumor responses or play a more regulatory role. We believe that MRCs play a critical role in cancer-related immune regulation and suggest that future anti-cancer therapies will focus on these abundant cells

Desarrollo de métodos inmunoprofilácticos y de innovación diagnostica a través de síntesis química de moléculas : segundo informe proyecto convenio año 2002

Este proyecto estudia la exploración de las proteínas y el papel de los aminoácidos a la respuesta inmunológica de las moléculas en los procesos invasivos. La base experimental en este proyecto, es la modificación de las propiedades químicas del enlace peptídico.CV 086-2002ConvenioNo. 00127-2002;En la caratula: Informe Final de InvestigaciónV.1. Informe final de Investigación Grupo funcional química síntesis -- Grupo funcional Biocatalisis -- Grupo funcional Resonancia magnética nuclear y diseño gráfico molecular. -- V.2. Informe final de Investigación Grupo funcional Biología molecular Malaria -- Informe final de Investigación Grupo funcional Biología molecular Tuberculosis -- Informe final de Investigación Grupo funcional Inmunología molecular -- Informe final de Investigación Grupo funcional Epidemiologia -- Informe final de Investigación Grupo funcional Fisiología molecular -- Informe final de Investigación Grupo funcional Biomatemáticas