University Scholar Series: Mary Pickering

Auguste Comte: An Intellectual Biography On November 17, 2010 Mary Pickering spoke in the University Scholar Series hosted by Provost Gerry Selter at the Dr. Martin Luther King, Jr. Library. Mary Pickering discussed her three-volume Pulitzer Prize nominated work entitled Auguste Comte: An Intellectual Biography. Comte was a French Philosopher and the father of sociology. Professor Pickering teaches courses at SJSU in French history, German history, European women\u27s history, and urban history.https://scholarworks.sjsu.edu/uss/1005/thumbnail.jp

Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation

Although it is unclear which cellular factor(s) is responsible for the genetic instability associated with initiating and sustaining cell transformation, it is known that most, if not all, cancers have mutations that inactivate the Rb-mediated growth control pathway. We show here that acute inactivation of Rb by RNA interference or expression of the E7 viral oncoprotein from human papillomavirus (HPV), and the resultant deregulation of one E2F family member, E2F1, leads to DNA double strand break (DSB) accumulation. These DSBs occur independent of apoptosis induction, and activation of ATM, NBS1, p53, or MAD2, and generation of reactive oxygen species (ROS). Although ROS accumulation is associated with DSBs generated from the mis-expression of another nuclear oncoprotein, c-MYC, we find that E2F1 does not contribute to c-MYC associated DSBs, indicating that the DSBs associated with these oncoproteins arise through distinct pathways. However, we find that small changes in E2F1 levels by inhibition of c-MYC transactivated microRNAs known to limit E2F1 protein expression, lead to DSB accumulation. These results suggest that despite the DSBs arising by different mechanisms, c-MYC assists in the regulation of E2F1-associated DSBs. We also find elevated levels of E2F1-associated DSBs in Rb mutated cancer cell lines in the absence of an exogenous DSB stimulus. These basal, E2F1-associated DSBs are substantially lower in Rb wildtype cancer cell lines that have p16ink4 inactivated or express HPV E7. However, we show that we can manipulate DSB levels in these cancer cell lines by modulating Rb and E2F1 activity and suggest that these results may be extended to breast tumor organ culture. Thus, Rb status is key to regulating both the proliferation promoting functions associated with E2F and for preventing DNA damage accumulation if E2F1 becomes deregulated. Taken together, these data suggest that loss of Rb creates strong selective pressure, via DSB accumulation, for inactivating p53 mutations and that E2F1 might contribute to the genetic instability associated with transformation and tumorigenesis

Understanding the Impact of Trauma, Violence and Abuse - An Exploration of the Experience of Exposure to Violence.

This portfolio thesis comprises of three parts: Part One: Systematic Literature Review Part one contains a systematic review which explores the use of Compassion Focussed Therapy (CFT) with adult survivors of violence, trauma, and abuse (VTA). A systematic search of five databases revealed 11 suitable papers, the findings of which are presented using narrative synthesis. Part Two: Empirical Paper Part two is a qualitative empirical study, which explored women’s experiences of being exposed to gender-based violence (GBV) in the media (i.e. the news and social media etc.). A reflexive thematic analysis revealed a total of three themes. Conclusions, implications and recommendations for future research were considered. Part Three: Appendices Part three contains the appendices for the previous two parts and also includes a reflective and epistemological statement

A memoir of Judge Ebenezer Thompson of Durham, New Hampshire : with some account of his parentage and offspring.

86 p. : ill. ; 22 c

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

It has been proposed that the E2F1 transcription factor serves as a link between the Rb/E2F proliferation pathway and the p53 apoptosis pathway by inducing the expression of p19ARF, a protein that regulates p53 stability. We find that although p19ARF contributes to p53 accumulation in response to E2F expression, p19ARF is not required for E2F1-mediated apoptosis. E2F1 can signal p53 phosphorylation in the absence of p19ARF, similar to the observed modifications to p53 in response to DNA damage. These modifications are not observed in the absence of p19ARF following expression of E2F2, an E2F family member that does not induce apoptosis in mouse embryo fibroblasts but can induce p19ARF and p53 protein expression. p53 modification is found to be crucial for E2F1-mediated apoptosis, and this apoptosis is compromised when E2F1 is coexpressed with a p53 mutant lacking many N- and C-terminal phosphorylation sites. Additionally, E2F1-mediated apoptosis is abolished in the presence of caffeine, an inhibitor of phosphatidylinositol 3-kinase-related kinases that phosphorylate p53. These findings suggest that p53 phosphorylation is a key step in E2F1-mediated apoptosis and that this modification can occur in the absence of p19ARF

Interviews with Charley King, Barbara Hall Maricle, Vern Kear, Sherry Smith, Elizabeth Stoskopt, Martha Margheim, Verna Schneider, Edith M. Hill, Master John Sackett, Rose Arnold, Olga Elizabeth Luschen Dennis, and Clarence Loredstsch

Interviews with Charley King, Barbara Hall Maricle, Vern Kear, Sherry Smith, Elizabeth Stoskopt, Martha Margheim, Verna Schneider, Edith M. Hill, Master John Sackett, Rose Arnold, Olga Elizabeth Luschen Dennis, and Clarence Loredstsch The first tape is missing. Content begins with the partial interview of Olga Elizabeth Luschen Dennis. 00:00:00 - Family in Russell County (partial) 00:01:02 - Meeting her husband for the first time 00:02:32 - Girlhood experiences and reminiscences 00:03:50 - Pre-recorded History of Fort Larned 00:07:04 - Unknown speaker, Kit Carson\u27s killing of a mule he mistook for an Indigenous American 00:10:46 - Buffalo Bill Cody 00:13:03 - Stories about the Kiowa 00:16:06 - Woodland Tribe in Pawnee County, KS 00:18:24 - Quivira Tribe in Pawnee County, KS 00:21:46 - Exhuming Indigenous remains in 1958 00:23:16 - Woodland Tribe pottery 00:27:32 - Dog skeleton 00:33:57 - Woodland Tribe weapons 00:35:42 - Woodland Tribe ornamentation 00:39:05 - Introduction to interview with Clarence Loredstsch by Louise Maxwell. This portion of the recording is muffled and difficult to understand. 00:39:43 - Fort Fletcher 00:45:30 - Graves and landmarkshttps://scholars.fhsu.edu/sackett/1054/thumbnail.jp

Pushing the limit of instrument capabilities

Chemically Peculiar (CP) stars have been subject of systematic research since more than 50 years. With the discovery of pulsation of some of the cool CP stars, the availability of advanced spectropolarimetric instrumentation and high signal- to-noise, high resolution spectroscopy, a new era of CP star research emerged about 20 years ago. Together with the success in ground-based observations, new space projects are developed that will greatly benefit for future investigations of these unique objects. In this contribution we will give an overview of some interesting results obtained recently from ground-based observations and discuss on future outstanding Gaia space mission and its impact on CP star research.Comment: Joint Discussion 04, Secsion 1, To appear in Highlights of Astronomy, Proc. of the XXVIIth IAU General Assembly, Rio de Janeiro, Brazil, August 2009, 9 page

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

Staphylococcus aureus is a leading cause of bovine mastitis worldwide. Despite some improved understanding of disease pathogenesis, progress towards new methods for the control of intramammary infections (IMI) has been limited, particularly in the field of vaccination. Although herd management programs have helped to reduce the number of clinical cases, S. aureus mastitis remains a major disease burden. This review summarizes the past 16 years of research on bovine S. aureus population genetics, and molecular pathogenesis that have been conducted worldwide. We describe the diversity of S. aureus associated with bovine mastitis and the geographical distribution of S. aureus clones in different continents. We also describe studies investigating the evolution of bovine S. aureus and the importance of host-adaptation in its emergence as a mastitis pathogen. The available information on the prevalence of virulence determinants and their functional relevance during the pathogenesis of bovine mastitis are also discussed. Although traits such as biofilm formation and innate immune evasion are critical for the persistence of bacteria, the current understanding of the key host-pathogen interactions that determine the outcome of S. aureus IMI is very limited. We suggest that greater investment in research into the genetic and molecular basis of bovine S. aureus pathogenesis is essential for the identification of novel therapeutic and vaccine targets