Improving the clinical value and utility of CGM systems: issues and recommendations: a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group

The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionize the use of intensive insulin therapy in diabetes; however, progress toward that vision has been gradual. Although increasing, the proportion of individuals using CGM rather than conventional systems for self-monitoring of blood glucose on a daily basis is still low in most parts of the world. Barriers to uptake include cost, measurement reliability (particularly with earlier-generation systems), human factors issues, lack of a standardized format for displaying results, and uncertainty on how best to use CGM data to make therapeutic decisions. This Scientific Statement makes recommendations for systemic improvements in clinical use and regulatory (pre- and postmarketing) handling of CGM devices. The aim is to improve safety and efficacy in order to support the advancement of the technology in achieving its potential to improve quality of life and health outcomes for more people with diabetes

Improving the clinical value and utility of CGM systems: issues and recommendations : a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group

The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towards that vision has been gradual. Although increasing, the proportion of individuals using CGM rather than conventional systems for self-monitoring of blood glucose on a daily basis is still low in most parts of the world. Barriers to uptake include cost, measurement reliability (particularly with earlier-generation systems), human factors issues, lack of a standardised format for displaying results and uncertainty on how best to use CGM data to make therapeutic decisions. This scientific statement makes recommendations for systemic improvements in clinical use and regulatory (pre- and postmarketing) handling of CGM devices. The aim is to improve safety and efficacy in order to support the advancement of the technology in achieving its potential to improve quality of life and health outcomes for more people with diabetes

Ancient Egypt 1923 Part 2

Part 2 of the 1923 Ancient Egypt books. Contents include the tomb at Byblos, a tomb with Aramaic inscriptions, the British school at Qau, the magic skin, Apries and the possibility of royal blood, and obelisks at Pylon VII.https://knowledge.e.southern.edu/kweeks_coll/1023/thumbnail.jp

Methods for treating bone deficit conditions with benzothiazole

" Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or ""linker"" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems. "Board of Regents, University of Texas Syste

Magnetohydrostatic solar prominences in near-potential coronal magnetic fields

We present numerical magnetohydrostatic solutions describing the gravitationally stratified, bulk equilibrium of cool, dense prominence plasma embedded in a near-potential coronal field. These solutions are calculated using the FINESSE magnetohydrodynamics equilibrium solver and describe the morphologies of magnetic field distributions in and around prominences and the cool prominence plasma that these fields support. The equilibrium condition for this class of problem is usually different in distinct subdomains, separated by free boundaries, across which solutions are matched by suitable continuity or jump conditions describing force balance. We employ our precise finite element elliptic solver to calculate solutions not accessible by previous analytical techniques with temperature or entropy prescribed as free functions of the magnetic flux function, including a range of values of the polytropic index, temperature variations mainly across magnetic field lines and photospheric field profiles sheared close to the polarity inversion line. Out of the many examples computed here, perhaps the most noteworthy is one which reproduces precisely the three-part structure often encountered in observations: a cool dense prominence within a cavity/flux rope embedded in a hot corona. The stability properties of these new equilibria, which may be relevant to solar eruptions, can be determined in the form of a full resistive MHD spectrum using a companion hyperbolic stability solver.Comment: To appear in ApJ August 200

Feasibility of utilizing the 200-inch Hale telescope as a deep-space optical receiver

Capturing the very faint optical communications signals expected from the Mars Laser Communication Demonstration (MLCD) experiment to fly aboard the Mars Telecommunications Orbiter (MTO) in 2009 requires a sensitive receiver placed at the focus of a large collecting aperture. For the purpose of demonstrating the potential of deep-space optical communication, it makes sense to employ a large astronomical telescope as a temporary receiver. Because of its large collecting aperture, its reputation as a well-run instrument, and its relative convenience, the 200-inch Hale Telescope on Palomar Mountain is being considered as a demonstration optical 'antenna' for the experiment. However, use of the telescope in this manner presents unique challenges to be overcome, the greatest of which is pointing the telescope and maintaining the communication link to within a few degrees of the Sun. This paper presents our candidate approaches for adapting the Hale telescope to meet the demonstration requirements, modifications to the facilities and infrastructure, the derivation of requirements for baffles and filters to meet the near-Sun pointing objectives, and initial data on the potential of candidate modifications to meet the requirements

The Long Period, Massive Binaries HD 37366 and HD 54662: Potential Targets for Long Baseline Optical Interferometry

We present the results from an optical spectroscopic analysis of the massive stars HD 37366 and HD 54662. We find that HD 37366 is a double-lined spectroscopic binary with a period of 31.8187 +/- 0.0004 days, and HD 54662 is also a double lined binary with a much longer period of 557.8 +/- 0.3 days. The primary of HD 37366 is classified as O9.5 V, and it contributes approximately two-thirds of the optical flux. The less luminous secondary is a broad-lined, early B-type main-sequence star. Tomographic reconstruction of the individual spectra of HD 37366 reveals absorption lines present in each component, enabling us to constrain the nature of the secondary and physical characteristics of both stars. Tomographic reconstruction was not possible for HD 54662; however, we do present mean spectra from our observations that show that the secondary component is approximately half as bright as the primary. The observed spectral energy distributions (SEDs) were fit with model SEDs and galactic reddening curves to determine the angular sizes of the stars. By assuming radii appropriate for their classifications, we determine distance ranges of 1.4 - 1.9 and 1.2 - 1.5 kpc for HD 37366 and HD 54662, respectively.Comment: 27 pages, 8 figures, Accepted for publication in Ap