3,308 research outputs found
Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes
Recommended from our members
The âABC modelâ: a non-hydrostatic toy model for use in convective-scale data assimilation investigations
In developing methods for convective-scale data assimilation (DA) it is necessary to consider the full range of motions governed by the compressible Navier-Stokes equations (including non-hydrostatic and ageostrophic flow). These equations describe motion on a wide range of time-scales with non-linear coupling. For the purpose of developing new DA techniques that suit the convective-scale problem it is helpful to use so-called âtoy modelsâ that are easy to run, and contain the same types of motion as the full equation set. Such a model needs to permit hydrostatic and geostrophic balance at large-scales, but to allow imbalance at small-scales, and in particular, it needs to exhibit intermittent convection-like behaviour. Existing âtoy modelsâ are not always sufficient for investigating these issues.
A simplified system of intermediate complexity derived from the Euler equations is presented, which supports dispersive gravity and acoustic modes. In this system the separation of time scales can be greatly reduced by changing the physical parameters. Unlike in existing toy models, this allows the acoustic modes to be treated explicitly, and hence inexpensively. In addition, the non-linear coupling induced by the equation of state is simplified. This means that the gravity and acoustic modes are less coupled than in conventional models. A vertical slice formulation is used which contains only dry dynamics. The model is shown to give physically reasonable results, and convective behaviour is generated by localised compressible effects. This model provides an affordable and flexible framework within which some of the complex issues of convective-scale DA can later be investigated. The model is called the âABC modelâ after the three tunable parameters introduced: A (the pure gravity wave frequency), B (the modulation of the divergent term in the continuity equation), and C (defining the compressibility)
LANDSAT TM image data quality analysis for energy-related applications
This project represents a no-cost agreement between National Aeronautic Space Administration Goddard Space Flight Center (NASA GSFC) and the Pacific Northwest Laboratory (PNL). PNL is a Department of Energy (DOE) national laboratory operted by Battelle Memorial Institute at its Pacific Northwest Laboratories in Richland, Washington. The objective of this investigation is to evaluate LANDSAT's thematic mapper (TM) data quality and utility characteristics from an energy research and technological perspective. Of main interest is the extent to which repetitive TM data might support DOE efforts relating to siting, developing, and monitoring energy-related facilities, and to basic geoscientific research. The investigation utilizes existing staff and facility capabilities, and ongoing programmatic activities at PNL and other DOE national laboratories to cooperatively assess the potential usefulness of the improved experimental TM data. The investigation involves: (1) both LANDSAT 4 and 5 TM data, (2) qualitative and quantitative use consideration, and 3) NASA P (corrected) and A (uncorrected) CCT analysis for a variety of sites of DOE interest. Initial results were presented at the LANDSAT Investigator's Workshops and at specialized LANDSAT TM sessions at various conferences
Magnetohydrostatic solar prominences in near-potential coronal magnetic fields
We present numerical magnetohydrostatic solutions describing the
gravitationally stratified, bulk equilibrium of cool, dense prominence plasma
embedded in a near-potential coronal field. These solutions are calculated
using the FINESSE magnetohydrodynamics equilibrium solver and describe the
morphologies of magnetic field distributions in and around prominences and the
cool prominence plasma that these fields support. The equilibrium condition for
this class of problem is usually different in distinct subdomains, separated by
free boundaries, across which solutions are matched by suitable continuity or
jump conditions describing force balance. We employ our precise finite element
elliptic solver to calculate solutions not accessible by previous analytical
techniques with temperature or entropy prescribed as free functions of the
magnetic flux function, including a range of values of the polytropic index,
temperature variations mainly across magnetic field lines and photospheric
field profiles sheared close to the polarity inversion line. Out of the many
examples computed here, perhaps the most noteworthy is one which reproduces
precisely the three-part structure often encountered in observations: a cool
dense prominence within a cavity/flux rope embedded in a hot corona. The
stability properties of these new equilibria, which may be relevant to solar
eruptions, can be determined in the form of a full resistive MHD spectrum using
a companion hyperbolic stability solver.Comment: To appear in ApJ August 200
Gauge Group and Topology Change
The purpose of this study is to examine the effect of topology change in the
initial universe. In this study, the concept of -cobordism is introduced to
argue about the topology change of the manifold on which a transformation group
acts. This -manifold has a fiber bundle structure if the group action is
free and is related to the spacetime in Kaluza-Klein theory or
Einstein-Yang-Mills system. Our results revealed that fundamental processes of
compactification in -manifolds. In these processes, the initial high
symmetry and multidimensional universe changes to present universe by the
mechanism which lowers the dimensions and symmetries.Comment: 8 page
Metformin, lipids and atherosclerosis prevention
Purpose of review: We provide an overview of recent publications that extend clinically relevant knowledge relating to metformin's effects on lipids and atherosclerotic vascular disease and/or provide insights into the drug's mechanisms of action on the heart and vasculature.
Recent findings: We focus on original research in humans or in human tissues. Several recently completed randomized clinical trials have reported effects of metformin on surrogate measures of atherosclerotic vascular disease, including carotidâintima media thickness, vascular reactivity and calcification in people with Type 1 (T1D) and Type 2 (T2D) diabetes as well as nondiabetic dysglycaemia. In addition, observational studies have provided novel insights into the mechanisms of metformin's effects on carotid plaque, monocytes/macrophages, vascular smooth muscle and endothelial cells, including via 5â-adenosine monophosphate-activated protein kinase (AMPK) activation.
Summary: Recent trials based on surrogate outcome measures have provided further data suggesting protective effects of metformin against vascular disease in youth and adults with Type 1 diabetes, as well as in adults with prediabetes and Type 2 diabetes. In parallel, human tissue and cell studies have provided new insights into pleiotropic effects of metformin and suggest novel drug targets. As metformin is an inexpensive agent with an established safety profile, larger scale clinical trials based on hard clinical outcomes [cardiovascular disease (CVD) events] are now indicated
Modeling the Sun's open magnetic flux and the heliospheric current sheet
By coupling a solar surface flux transport model with an extrapolation of the
heliospheric field, we simulate the evolution of the Sun's open magnetic flux
and the heliospheric current sheet (HCS) based on observational data of sunspot
groups since 1976. The results are consistent with measurements of the
interplanetary magnetic field near Earth and with the tilt angle of the HCS as
derived from extrapolation of the observed solar surface field. This opens the
possibility for an improved reconstruction of the Sun's open flux and the HCS
into the past on the basis of empirical sunspot data.Comment: 16 pages, 5 figures, Accepted for publication in Ap
The QUEST large area CCD camera
We have designed, constructed, and put into operation a very large area CCD camera that covers the field of view of the 1.2 m Samuel Oschin Schmidt Telescope at the Palomar Observatory. The camera consists of 112 CCDs arranged in a mosaic of four rows with 28 CCDs each. The CCDs are 600 x 2400 pixel Sarnoff thinned, back-illuminated devices with 13 ”m x 13 ”m pixels. The camera covers an area of 4.6° x 3.6° on the sky with an active area of 9.6 deg_2. This camera has been installed at the prime focus of the telescope and commissioned, and scientific-quality observations on the Palomar-QUEST Variability Sky Survey were started in 2003 September. The design considerations, construction features, and performance parameters of this camera are described in this paper
- âŠ